N-acylated pyrazolines, compositions and use

ABSTRACT

N-sulfenylated and N-acylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their environment. The pyrazolines are selected from those of Formulae I to III wherein R1, R2, R3, Q, A, B, J, K, Y, m, n and p are as defined in the text:    &lt;IMAGE&gt;  I

RELATIONSHIP TO OTHER APPLICATIONS

This application is a continuation of U.S. Ser. No. 08/004,860, filed Jan. 15, 1993, now abandoned, which is a divisional of U.S. Ser. No. 07/659,402, filed Mar. 12, 1991, now U.S. Pat. No. 5,196,408, which is a continuation-in-part of U.S. Ser. No. 07/304,011, filed Jan. 25, 1989, U.S. Ser. No. 07/249,881 and U.S. Ser. No. 249,882, both filed Sep. 27, 1988, all of which are abandoned.

BACKGROUND OF THE INVENTION

The following publications disclose pyrazolines:

    ______________________________________                                         U.S. 4,070,365      EPA 21,506                                                 U.S. 4,156,007      EPA 58,424                                                 U.S. 4,174,393      EPA 65,334                                                 U.S. 4,663,341      EPA 113,213                                                WO 83/05046         EPA 153,127                                                WO 88/07994         EPA 286,346                                                WO 89/00562         EPA 300,692                                                ______________________________________                                          Grosscurt et al., J. Agric. Food Chem., vol. 27, No. 2 (1979).

SUMMARY OF THE INVENTION

This invention pertains to compounds of Formulae I, II and III, including all geometric and stereoisomers, agriculturally suitable salts thereof, compositions containing them and their use as arthropodicides in agricultural and home uses. Hereafter, the compounds, isomers and salts are referred to as compound(s) for the sake of simplicity. The compounds are: ##STR2## wherein A is a 1, 2 or 3-atom bridge comprising 0 to 3 carbon atoms, 0 to 1 oxygen atoms, NR₆, or S(O)q, wherein each carbon individually can be substituted with 1 to 2 substituents selected from 1 to 2 halogen, C₁ to C₆ alkyl, C₂ to C₄ alkoxycarbonyl or phenyl optionally substituted with 1 to 3 substituents independently selected from W and one of the carbon atoms can be combined into the group C(O) or C(S);

B is H, C₁ to C₆ alkyl, C₄ to C₇ cycloalkyl alkyl, C₃ to C₆ cycloalkyl optionally substituted with 1 to 2 halogens or 1 to 2 CH_(3;) C₁ to C₆ haloalkyl, C₂ to C₆ alkenyl, C₂ to C₆ haloalkenyl, C₂ to C₆ alkynyl, OR₇, C₂ to C₆ alkoxyalkyl, C₂ to C₆ cyanoalkyl, C₃ to C₈ alkoxycarbonylalkyl, CO₂ R₄, C(O)R₄, C(O)NR₄ R₅, C(S)NR₄ R₅, C(S)R₄, C(S)SR₄, phenyl, phenyl substituted by (R₁₄)p, benzyl, or benzyl substituted with 1 to 3 substituents independently selected from W;

J is H, C₁ to C₄ alkyl or phenyl optionally substituted with W;

K is H or CH₃ ;

q is 0, 1 or 2;

R₁, R₂, R₃ and R₁₄ are independently selected from R₄, halogen, CN, N₃, SCN, NO₂, OR₄, SR₄, S(O)R₄, S(O)₂ R₄, OC(O)R₄, OS(O)₂ R₄, CO₂ R₄, C(O)R₄, C(O)NR₄ R₅, S(O)₂ NR₄ R₅, NR₄ R₅, NR₅ C(O)R₄, OC(O)NHR₄, NR₅ C(O)NHR₄ and NR₅ S(O)₂ R_(4;) or when m, n or p is 2, R₁, R₂, R₃ or R₁₄ can independently be taken together as OCH₂ O, OCH₂ CH₂ O or CH₂ CH₂ O, to form a 5 or 6-membered ring, each of which can be independently substituted with 1 to 4 halogen atoms or 1 to 2 methyl groups;

R₄ is selected from H, C₁ to C₆ alkyl, C₃ to C₆ cycloalkyl, C₃ to C₈ alkoxycarbonylalkyl, C₃ to C₆ alkenyl, C₃ to C₆ alkynyl, C₁ to C₆ haloalkyl, C₃ to C₆ haloalkenyl, C₁ to C₆ alkyl substituted with CN, CO₂ CH₃, CO₂ CH₂ CH₃, OCH₃, OCH₂ CH₃, SCH₃, SCH₂ CH₃ or NO₂, or R₄ is phenyl or benzyl, either optionally substituted with W; or R₄ and R₅ can be taken together as (CH₂)₄, (CH₂)₅ or CH₂ CH₂ OCH₂ CH₂ ;

R₅ is selected from H, C₁ to C₄ alkyl, C₃ to C₄ alkenyl, C₃ to C₄ alkynyl or C₁ to C₄ haloalkyl;

m, n and p are independently 1 to 3;

W is halogen, CN, NO₂, C₁ to C₂ alkyl, C₁ to C₂ haloalkyl, C₁ to C₂ alkoxy, C₁ to C₂ haloalkoxy, C₁ to C₂ alkylthio, C₁ to C₂ haloalkylthio, C₁ to C₂ alkylsulfonyl or C₁ to C₂ haloalkylsulfonyl;

R₆ is H, C₁ to C₄ alkyl, C₁ to C₄ haloalkyl, C₂ to C₄ alkenyl, C₂ to C₄ haloalkenyl, phenyl optionally substituted with W or benzyl optionally substituted with W;

R₇ is H, C₁ to C₄ alkyl, C₂ to C₄ alkenyl, C₂ to C₄ alkynyl, C₂ to C₄ alkylcarbonyl, C₂ to C₄ alkoxycarbonyl or C₁ -C₄ alkylsulfonyl;

Q is SX, C₂ to C₂₂ alkoxycarbonyl, C₂ to C₂₂ haloalkoxycarbonyl, C₇ to C₁₅ phenoxycarbonyl optionally substituted with 1 to 3 substituents selected from W; C₇ to C₁₅ phenyl carbonyl optionally substituted with 1 to 3 substituents independently selected from w; C₂ to C₂₂ alkyl carbonyl, C₂ to C₂₂ haloalkyl carbonyl, CHO, C(O)CO₂ R₅, or C₈ to C₁₂ benzyloxycarbonyl optionally substituted with 1 to 3 substituents independently selected from W; when Q is other than SX, R₃ is other than CO₂ R₄, C(O)R₄, SO₂ NR₄ R₅ or CONR₄ R₅ ;

Y is C₅ to C₂₂ alkyl, C₂ to C₂₂ haloalkyl, C₅ to C₂₂ alkoxyalkyl, C₄ to C₂₂ alkoxyalkoxyalkyl, C₅ to C₁₂ alkylthio, C₅ to C₁₂ haloalkylthio, C₅ to C₂₂ alkylcarbonyl, C₅ to C₂₂ haloalkylcarbonyl, C₅ to C₂₂ alkoxycarbonyl, C₃ to C₂₂ haloalkoxycarbonyl, or SX;

Z is C₇ to C₂₂ alkyl, C₂ to C₂₂ haloalkyl, C₇ to C₂₂ alkoxyalkyl, C₄ to C₂₂ alkoxyalkoxyalkyl, C₇ to C₁₂ alkylthio, C₇ to C₁₂ haloalkylthio, C₇ to C₂₂ alkylcarbonyl, C₇ to C₂₂ haloalkylcarbonyl, C₇ to C₂₂ alkoxycarbonyl, C₃ to C₂₂ haloalkoxycarbonyl, C₇ to C₁₅ phenylcarbonyl optionally substituted by 1 to 3 substituents independently selected from W; or SX; ##STR3## R₈ and R₁₂ are independently C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, C₃ to C₆ cycloalkyl, C₄ to C₇ cycloalkylalkyl, phenyl optionally substituted by 1 to 2 substituents selected from W, benzyl optionally substituted by 1 to 2 substituents independently selected from W, phenethyl optionally substituted by 1 to 2 substituents independently selected from W, C₂ to C₆ cyanoalkyl, C₂ to C₆ alkoxyalkyl, C₃ to C₈ alkoxycarbonylalkyl, C₄ to C₈ dialkylaminocarbonylalkyl; or R₈ and R₁₂ can be taken together as (CH₂)₄, (CH₂)₅ or (CH₂)₂ O(CH₂)₂,

R₉ is F, C₁ to C₂₂ alkyl, C₃ to C₆ cycloalkyl, C₃ to C₆ cycloalkoxy, C₂ to C₈ dialkylamino, C₁ to C₆ haloalkyl, phenyl or phenoxy either optionally substituted by 1 to 2 substituents independently selected from W; C₁ to C₂₂ alkoxy, C₁ to C₄ alkoxy substituted by cyano, nitro, C₂ to C₄ alkoxy, C₄ to C₈ alkoxyalkoxy, C₁ to C₂ alkylthio, C₂ to C₃ alkoxycarbonyl, C₃ to C₅ dialkylaminocarbonyl, phenyl or 1 to 6 halogens; or R₉ is morpholino, piperidino or pyrrolidino, 1-naphthoxy, 2,2-dimethyl-2,3-dihydrobenzofuranoxy-7 or ON═C(CH₃)SCH₃ ;

R₁₀ and R₁₁ are independently C₁ to C₄ alkyl, C₂ to C₄ haloalkyl or phenyl optionally . substituted by 1 to 2 substituents independently selected from W; or R₁₀ and R₁₁ can be taken together as (CH₂)₂, (CH₂)₃ or CH₂ C(CH₃)₂ CH₂ ;

Y' is S or O; and

a is 0 to 2.

Preferred compounds A are those of Formula I, II or III wherein:

R₁, R₂, R₃ and R₁₄ are independently R₄, CO₂ R₄, halogen, CN, NO₂, OR₄, SR₄, S(O)R₄, S(O)₂ R₄ or NR₄ R₅, or when m, n or p is 2;

R₁, R₂, R₃ or R₁₄ can be taken together as OCH₂ O, OCH₂ CH₂ O or CH₂ CH₂ O, each of which can be substituted with 1 to 4 halogen atoms or 1 to 2 methyl groups;

R₄ is C₁ to C₂ alkyl, C₃ to C₄ alkenyl, C₁ to C₂ haloalkyl, C₃ to C₄ haloalkenyl or phenyl optionally substituted with halogen;

R₅ is H or C₁ to C₂ alkyl;

Q is SX, CHO, C₂ to C₆ alkoxycarbonyl, C₂ to C₆ haloalkoxycarbonyl, C₂ to C₆ alkylcarbonyl, C₂ to C₄ haloalkylcarbonyl, C₇ to C₁₀ phenoxycarbonyl, C₇ to C₁₀ phenylcarbonyl or C₈ to C₁₀ benzyloxycarbonyl each phenoxy, phenyl or benzyloxy group optionally substituted with 1 to 2 substituents selected from W;

X is X₁, X₂, X₃, X₄ or X₅ ;

R₈ and R₁₂ are independently C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, C₅ to C₆ cycloalkyl, C₃ to C₈ alkoxycarbonylalkyl, phenyl, benzyl or phenethyl, each optionally independently substituted with W; or R₈ and R₁₂ can be taken together as (CH₂)₄, (CH₂)₅ or (CH₂)₂ O(CH₂)₂ ;

R₁₀ and R₁₁ are independently C₁ to C₃ alkyl or phenyl;

a is 2;

Formula III is ##STR4## X' is O or S; t is 0, 1 or 2;

V is O, S(O)q, or NR₆ ;

Z' is O or NR₆ ;

R₁₃ is H, halogen, C₁ to C₆ alkyl, C₂ to C₄ alkoxycarbonyl, phenyl or phenyl substituted by 1 to 3 substituents independently selected from W; and

g is 0, 1 or 2.

Preferred compounds B are compounds A wherein:

R₁ is halogen, CN, NO₂, OCF₂ H, OCF₃, OCH₂ CF₃, OCF₂ CF₂ H, CF₃ or when m is 2 then R₁ may be taken together as CH₂ C(CH₃)₂ O or CF₂ CF₂ O to form a 5 membered ring;

R₂ is H, halogen, CN, NO₂, OCH₃, OCF₂ H, OCH₂ CF₃, OCF₃, SCH₃, SCF₂ H, SCF₃, CF₃, OCF₂ CF₂ H or phenoxy;

R₃ and R₁₄ are independently R₂ or CO₂ R₄ ;

Q is SX, C₂ to C₄ alkoxycarbonyl, C₂ to C₄ alkylcarbonyl, C₇ to C₈ phenylcarbonyl or CHO;

X is X₁, X₂ or X₃ ;

R₈ is C₁ to C₄ alkyl, CF₃, cyclohexyl, phenyl optionally substituted with W or benzyl optionally substituted by W;

R₉ is F, C₁ to C₂₂ alkyl, C₁ to C₆ haloalkyl, phenyl or phenoxy optionally substituted by W; C₁ to C₂₂ alkoxy, dimethylamino or C₁ to C₄ alkoxy substituted with NO₂, C₂ to C₄ alkoxy or 1 to 6 halogens;

m, n or p are independently 1 to 2 and one substituent is in the 4-position and

B is H, C₁ -C₄ alkyl, CO₂ R₄, C(O)R₄ or phenyl optionally substituted by (R₁₄)_(p).

Preferred compounds C are preferred compounds B wherein:

X is X₁ ;

R₈ is C₁ to C₄ alkyl;

R₉ is C₁ to C22 alkoxy;

Formula III is III-1 or III-2;

V is O or CH₂ ;

t is 1; and

R₁₃ is H.

Preferred compounds D are preferred compounds B wherein:

X is X₂ ;

R₈ is C₁ to C₄ alkyl or phenyl optionally substituted with CH₃ or C_(1;) and

R₉ is C₁ to C₆ alkyl, C₁ to C₆ haloalkyl, dimethylamino or phenyl optionally substituted with CH₃ or Cl.

Preferred compounds E are preferred compounds C of Formula I.

Preferred compounds F are preferred compounds B of Formula II.

Preferred compounds G are preferred compounds B of Formula III.

Specifically preferred are the compounds:

H. methyl 3,4 -di-(4-chlorophenyl)-1-[[N-[[(etho xycarbonyl)(1-methylethyl)-amino]thio]-N-[4-(trifluoromethyl)-phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazole of preferred E;

I. N-acetyl-3,4-bis(4-chloropheny)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-carboxamide of preferred F; and

J. methyl 7-chloro-3,3a,4,5-tetrahydro-2-[[N-[[N-methyl-N-[octadecyloxy)-carbonyl]amino]thio]-N -[4-(trifluoro-methyl)-phenyl]amino]carbonyl]-2H-benz-[g]indazole-3a-carboxylate of preferred G.

DETAILS OF THE INVENTION

Compounds of Formulae I, II and III can be prepared by the reaction of a pyrazoline compound of Formula V, VI or VII with a sulfenyl halide of Formula IV. ##STR5## wherein Y in Formula IV represents a halogen such as chloro, bromo, or iodo.

The treatment of V, VI or VII with IV is carried out by mixing the two reagents in the presence of a base and a solvent. Suitable bases are the tertiary amines such as triethylamine or pyridine. Alkali metal bases such as sodium hydride or potassium tert-butoxide or organo lithium bases such as aryl or alkyllithium also can be utilized.

Suitable solvents include methylene chloride, tetrahydrofuran or ether. In some cases, the base can also be used as the solvent, e.g., pyridine. In most cases, it is desirable to mix compounds of Formula V, VI or VII and the desired base at a low temperature of about 5° C. to -70° C. which is held at this temperature during treatment with the appropriate amount of compounds of Formula IV. The mixture is then warmed to room temperature to complete the reaction. Generally, it is desirable to employ a moderate stoichiometric excess, up to 10% of the base and compounds of Formula IV relative to compounds of Formula V, VI or VII. Water should be excluded from the reaction mixture by using anhydrous reagents and conducting the treatment in a nitrogen atmosphere. The product is isolated and purified by conventional techniques as demonstrated in Example 1. The pyrazoline precursors of Formula V, VI, and VII are compounds that can be prepared by methods known to those skilled in the art. The methods of pyrazoline synthesis have been recently reviewed by E1-Rayyes and Al-Awadi in "Synthesis" page 1028 to 1042, November 1985.

Compounds of Formula V wherein B═H can be prepared by the following sequence of reactions as shown in Scheme 1. ##STR6##

In another embodiment, certain compounds of Formula V wherein B is other than H can be prepared directly from compounds of Formula V wherein B is H by further treatment with a base and the appropriate type of electrophile as illustrated by Scheme 2. ##STR7##

Compounds of Formula V where B is also phenyl or substituted phenyl can be prepared by reaction of a substituted ketone of Formula X with hydrazine as shown in Scheme 3. ##STR8##

For compounds of Formula VI, Grosscurt et al., have published the synthesis of 3,4-diphenyl-1-phenylcarbamoyl-2-pyrazolines in Journal of Agricultural and Food Chemistry, 27:406-409 (1979). Similar methods of synthesis are also presented in U.S. Pat. No. 4,633,341. Compounds of Formula VII have been prepared using procedures indicated in PCT WO 88/05046.

Sulfenyl halides of the type XSY (Formula IV) wherein X and Y are as specified in this disclosure are known in the literature. A review article by Kule in Synthesis, 561, (1970) describes the chemistry and preparation of the majority of sulfenyl halides utilized in this invention. The synthesis of N-chlorosulfenylcarbamates was described in U.S. Pat. No. 3,843,689. Other sulfenyl halides can be prepared by the general procedures described in these literature examples or obvious modifications thereof.

Compounds of Formula I (Q is other than SX) are synthesized from compounds of Formula VI. Reaction of compounds of Formula VI in the presence of an acid acceptor with electrophilic carbonyl-containing reagents results in substitution on nitrogen. Strong bases known to deprotonate ureas such as potassium t-butoxide, potassium hydride and sodium hydride are the preferred acid acceptors in the process. Suitable electrophiles include, but are not restricted to, acyl halides, acid anhydrides, carbonates, and chloroformates. The reaction sequence is normally run in the temperature range of -10° to 25° C., but can be run at temperatures as high as 110° C. or as low as -50° C. in certain cases. Solvents which are not deprotonated under the conditions of the reaction such as tetrahydrofuran, dimethylformamide, dimethoxyethane, and diethyl ether are preferred. The electrophiles used in this process are well known to those skilled in the art and are generally commercially available. ##STR9## wherein: QX is selected from acyl halides, chloroformates and acid anhydrides.

The following Examples illustrate the invention.

EXAMPLE 1

3,3a, 4,5-Tetrahydro-3a-methoxycarbonyl-N[4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

Step A: 3,3a,4,5-Tetrahydro-N-[4-(trifluoromethyl)phenyl]-2H-benz[g]indazole-2-carboxamide

A mixture of 10.0 g of α-tetralone, 2.0 g of paraformaldehyde, 6.5 g of dimethylamine hydrochloride and 1.75 ml of conc. HCl in 20 ml of ethanol was heated at reflux for 24 h, cooled to room temperature and thenpartitioned between ether and water. The aqueous extracts were made basic with 1N aqueous NaOH and extracted with ether. The ether extracts were dried over magnesium sulfate and concentrated to 12.3 g of a yellow oil. The residual oil was dissolved in 40 ml of n-propyl alcohol, combined with6.7 ml of hydrazine hydrate and heated at reflux for 1 h. The reaction mixture was then concentrated under vacuum, partitioned between 5% aqueousNaHCO₃ and methylene chloride and dried over magnesium sulfate. To the-methylene chloride extracts were added 12.5 g of 4-trifluoromethylphenyl isocyanate and the mixture was then refluxed one hour, cooled to room temperature and concentrated to 26.1 g of a brown oil. Chromatography on silica gel followed by trituration with ether afforded 11.78 g of the title compound as a tan powder, m.p. 149°-151° C.

1H NMR (CDCl₃), δ1.9 (m, 1H), 2.4 (m, 1H), 3.0 (m, 2H), 3.5 (m,2H), 4.4 (m, 1H), 7.3 (m,3H), 7.58 (d,2H), 7.65 (d,2H), 8.0 (d,2H), 8.3(bs,1H).

Step B: 3,3a,4,5-tetrahydro-3a-methoxycarbonyl-N-[4'-(trifluoromethyl)phenyl]-2H-benz[g]-indazole -2-carboxamide

To a solution of 0.9 ml of diisopropylamine in 10 ml of THF, at -78°C., was added 2.3 ml of 2.5 M n-butyl lithium in hexane and the mixture wasstirred for 5 mins. To this solution was added a solution of 1.0 g of the title compound of Step A in 5 ml of THF. The reaction was warmed to 0° C., recooled to -78° C. and then 0.75 ml of methyl chloroformate was added. The reaction mixture was then stirred for 24 h, with gradual warming to room temperature, quenched with 0.5 ml of glacial acetic acid, and poured into a 5% solution of aqueous NaHCO₃. The mixture was extracted with chloroform, dried over magnesium sulfate and concentrated. Chromatography on silica gel with 30% ethyl acetate hexane afforded 0.25 g of the title compound, m.p. 177° to 180° C.

¹ H NMR (CDCl₃), δ2.1 (m, 1H), 2.7 (m, 1H), 3.0 (m,2H), 3.71 (s,3H), 3.76 (d,1H), 4.58 (d, 1H), 7.3 (m,3H), 7.57 (d,2H), 7.66 (d,2H), 8.0 (d,1H), 8.22 (s,1H).

Step C: Ethyl (1-methylethyl)carbamate

To a solution of ethyl chloroformate (21.7 g, 0.2 mol) in 200 ml ether cooled to 0° C. was added dropwise 35.7 ml of isopropylamine with stirring and cooling. After complete addition of the amine, the reaction mixture was stirred at room temperature for an additional 0.5 hour. The reaction mixture was filtered, and the ether solution was washed with water, and dried over magnesium sulfate. Evaporation of the ether and distillation of the residue in a Kugelrohr apparatus resulted in 22.6 g ofthe title compound S.p.: 50°-66° C. (bath temperature) at 1.5mm Hg.

Step D: Ethyl (chlorosulfenyl)(1-methylethyl)carbamate

To a solution of ethyl (1-methylethyl)carbamate (13.1 g, 0.1 mol) in 100 mlmethylene chloride cooled to 0° C. was added sulfur dichloride (11.3g, 0.11 mol) in one portion. While maintaining the temperature of the mixture at 0° C., pyridine (8.7 g, 0.11 mol) was added dropwise over eleven minutes. After complete addition of the pyridine the temperature was allowed to rise to room temperature and stirring was continued for additional 1.5 hours. The mixture was let stand overnight. Methylene chloride was evaporated under vacuum and 100 ml hexane was added. Filteration of the pyridine hydrochloride and evaporation of hexaneresulted in an orange oil which was distilled in a Kugelrohr apparatus to give 12.5 g of the title compound Bp: 64°-80° (bath temperature) at 1.4 mm Hg.

Step E: 3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-[N'-(1-methyl ethyl)-N'-(ethoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

To a solution of the title compound of Step B (2.0 g, 4.8 mmol) in 5 0 ml methylene chloride cooled to 0° C. was added triethylamine (1.0 g, 0.01 mol) and ethyl (chlorosulfenyl) (1-methylethyl)carbamate from Step D (1.4 g, 7.7 mmol). The mixture was allowed to warm to room temperature andstirred for one hour. The crude mixture was purified by silica column chromatography using ether-hexane (1:2) as eluent. The title compound (2.38 g) was obtained in about 90% purity (mp: 130°-134° ). Extraction of the product with ether-hexane (2:1) gave 1.8 g of highly pure material mp: 139°-140° C.

¹ H NMR (CDCl₃); δ0.92 (t,3H), 1.26 (d,3H), 1.35 (d,3H), 1.95 (m, 1H ), 2.7 (m, 1H), 2.95 (m, 2H), 3.67 (s,3H), 3.8 (m,3H), 4.5 (m,2H), 7.2 (m,3H), 7.45 (d,3H), 7.65 (d,2H ).

EXAMPLE 2

3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(1-methyl propoxylcarbonylsulfenyl)-2H-benz[g]-indazole-2-carboxamide.

Step A: (1-methylpropoxycarbonyl)sulfenyl chloride

Chlorocarbonylsulfenyl chloride (13.1 g, 0.1 mol) was mixed with 2-butanol (6.7 g, 0.09 mol) and warmed to about 35° to 40° C. for one hour. Distillation resulted in the title compound (5.93 g) Bp. 70° C./0.8 mm Hg. NMR spectrum was consistent with the structure.

Step B: 3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(1-methyl propoxycarbonylsulfenyl)-2H-benz[g]indazole2-carboxamide.

To a solution of the title compound of Step B (Example 1) 0.4 g, 0.96 mmol)in 5 ml methylene chloride was added triethylamine (0.12 g) and cooled to 0° C. To this solution was added (1-methylpropoxycarbonyl)sulfenyl chloride (Step A) (0.2 g, 0.0012 mol). The mixture was stirred at room temperature for one hour. At this stage thin layer chromatography indicated only partial conversion, therefor, additional amounts of (1-methylpropoxycarbonyl)sulfenyl chloride (0.2 g) and triethylamine (0.12g) was added and the mixture was let stand over night. The reaction mixturewas subjected to silica gel column chromatography using hexane-ether (7:1) as eluent. The title compound was obtained (0 g) in high purity; m.p.: 125°-126° C.

¹ H NMR (CDCl₃): δ0.9 (m,3H), 1.3 (m,3H), 1.6 (m,2H) , 1.9 (m, 1H), 2.8 (m,3H), 3.67 (s,3H), 3.8 (d,1H), (d,1H), 5.0 (m, 1H), 7.05 (m,3H), 7.25 (m, 1H), 7.5 (d,2H), 7.57 (d,2H).

EXAMPLE 3

3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4(trifluoromethyl)phenyl]-N-(dibutylaminosulfenyl)-2H -benz[g]indazole-2-carboxamide

Step A: N,N'-bis-(dibutylamino)disulfide

To a solution of dibutylamine (52 g, 0.4 mol) in 200 ml hexane cooled to 0° C. was added sulfur monochloride (13.5 g, 0.1 mol) dropwise withstirring over a period of 20 minutes. The reaction mixture was warmed up toroom temperature and stirring was continued for 30 minutes. The reaction mixture was filtered and hexane was evaporated to yield 30.1 g of the title compound.

Step B: Dibutylaminosulfenylchloride

To a solution of N,N'-bis-(dibutylamino)disulfide (13.2 g, 0.05 mol) in 12 ml carbon tetrachloride was added. Sulfuryl chloride (6.75 g, 0.05 mol) was added dropwise at ambient temperature. Then heated to about 60°C. for 10 minutes, and distilled to give the title compound (7.55 g) as a yellow liquid. Bp: 80°-87° C. at 0.6 mm Hg.

Step C: 3,3a,4,5-Tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N-(dibutylaminosulfenyl)-2H -benz[g]indazole-2-carboxamide.

To a solution of the title compound of Step B (Example 1) (0.4 g, 0.96 mmol) in 8 ml methylene chloride cooled to 0° C. was added triethylamine (0.15 g) and dibutylaminosulfenylchloride (0.2 g). The reaction mixture was warmed to room temperature and stirred for one hour. The mixture was subjected to silica gel column chromatography using hexane-ether (6:1) as the eluent. The title compound was obtained (0.24 g)in high purity.

¹ H NMR (CDCl₃): δ0.7 to 1.7 (m,14H), 1.9 (m,1H,), 2.6 to 3.1 (m,7H), 3.67 (s,3H), 3.75 (d,1H), 4.45 (d,1H), 7.1 (m,3H), 7.25 (m, 1H), 7.4 (d,2H), 7.6 (d,2H).

EXAMPLE 4

7-Chloro-3,3a,4,5-tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]-N--[N'-(methyl)-N'-(hexoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

Step A: ((2-(3-chlorophenyl)ethyl)methanesulfonate

To a 0° C. solution of 30.0 g of 3-chlorophenethyl alcohol and 15.3 ml of methane sulfonyl chloride in 150 ml of THF was added, dropwise, a solution of 28.0 ml of triethylamine in 50 ml of THF. The reaction was warmed to room temperature, stirred overnight, and then filtered. The filtrate was partitioned between aqueous sodium bicarbonate and ether. Theorganic extracts were then dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford 45.93 g of a clear, colorless oil.

Step B: 3-chlorobenzenebutanoic acid

To a mixture of 8.0 g of 60% sodium hydride in 300 ml of THF, under N₂, was added dropwise a solution of 31.0 ml of diethyl malonate in 50 ml of THF. Upon complete addition of the diethyl malonate, a pale yellow homogenous solution was obtained. To this was added a solution of 45.93 g of the sulfonate from Step A and the mixture was then heated at reflux overnight. The reaction was then cooled to room temperature, pouredinto 400 ml of 1N HCl, and extracted with ether. The ether extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford 68.9 g of a yellow oil. The crude oil was dissolved in 400 ml of methanol, 100 ml of H₂ O and 40 ml of 50% aqueous NaOH. Thereaction was stirred overnight and the methanol was then removed at reducedpressure. The crude residue was partitioned between H₂ O and ether, the aqueous extracts were acidified with concentrated HCl and then extracted several times with ether. The ether extracts were dried over magne- sium sulfate, filtered and concentrated to afford 51.7 g of a yellow oil. The crude residue was dissolved in 200 ml of toluene and heated at reflux for 4 days under N₂ to effect decarboxylation. After this time toluene was removed by concentration at reduced pressure to afford 35.72 g of a yellow oil. ¹ H NMR analysis of the crude product was consistent with 3-chlorobenzene- butenoic acid of purity estimated to be 80%. The crude product was used without further purification directly in the next step.

Step C: 6-chloro-3,4-dihydro-1(2H)-naphthalenone

A mixture of 35.72 of the product from Step B and 50 ml of thionyl chloridewas heated at reflux for 2 hours and then stirred at room temperature for 18 hours. After this time thionyl chloride was removed at reduced pressureand the product was dissolved in carbon tetrachloride and concentrated at reduced pressure. The residue was dissolved in 150 ml of dichloroethane cooled to 0° C. and 28 g of aluminum chloride was added portionwiseover about 1 hr in approximately 3 g portions. After stirring for 3 hrs thereaction was poured over a mixture of ice/1N HCl and extracted three times with methylene chloride. The organic extracts were dried over magnesium sulfate and concentrated to approximately 30 g of a brown oil. Chromatography on silica gel with 10% ethyl acetate/hexane afforded 17.83 g of 6-chloro-3,4-dihydro-1(2H)-naphthalenone as a brown oil. ¹ H NMRwas consistent with the structure.

Step D: 7-chloro-3,3a,4-5-tetrahydro-N-[4-(trifluoromethyl)phenyl]-2H-benz[g]-indazole -2-carboxamide

A mixture of 6-chloro-3,4-dihydro-1(2H)-naphthalenone (Step C), 2.5 g of dimethylamine hydrochloride, 1.0 g of paraformaldehyde, 0.7 ml of concentrated HCl and 15 ml of ethanol was combined and heated at reflux for 18 hrs. The reaction was then concentrated at reduced pressure and partitioned between H₂ O and ether. The aqueous extracts were made baic with 1N NaOH and then extracted three times with ether. The ether extracts were dried over magnesium sulfate and concentrated to 4.64 g of ayellow oil. This compound was dissolved in 25 ml of ethanol and 1.5 ml of hydrazine hydrate was added followed by 5 to 6 drops of 50% sodium hydroxide. The reaction was then heated at reflux, under N₂, for 2 to3 hrs after which time it was cooled and most of the ethanol was removed byconcentration at reduced pressure. The crude residue was partitioned between saturated aqueous sodium carbonate and methylene chloride. The methylene chloride extracts were dried over magnesium sulfate and filtered. The methylene chloride extracts were then combined with 3.5 g of4-trifluoromethylphenyl isocyanate and stirred under N₂ overnight. Thereaction was then concentrated and the crude residue triturated with ether to afford 3.35 g of the title compound as a white powder, m.p. 196°to 199° C.

¹ H NMR (CDCl₃) δ1.9 (m, 1H), 2.2 (m, 1H), 3.0 (m,2H), 3.5 (m,2H), 4.43 (m, 1H), 7.24 (m,2H), 7.55 (d,2H), 7.67 (d,2H), 7.92 (a,1H), 8.20 (s,1H).

Step E: 7-chloro-3,3a,4,5-tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]2H-benz[g]indazole-2-carboxamide

A solution of 50 ml of THF and 6.7 ml of diisopropylamine was cooled under N₂ to -78° C. and then 17.5 ml of 2.5 M n-butyllrithium in hexane was added. After 5 min, a solution of 7.8 g of the title compound of Step D in 15 ml of THF was added dropwise and the dark red solution that formed was stirred at -78° C. for an additional 15 min. After this time a solution of 4.6 ml of methyl chloroformate in 10 ml of THF wasadded dropwise and the red color dissipated rapidly. The reaction was warmed to room temperature and after 1 hr quenched with 5% aqueous sodium bicarbonate. The reaction mixture was partitioned between ether and 5% aqueous sodium bicarbonate. The ether extracts were dried over magnesium sulfate and concentrated to 14.1 g of a yellow oily solid. The crude product was triturated with ether and the resulting white precipitate was filtered and dried to afford 5.56 g of the title compound as a white solid, m.p. 234° to 236° C.

¹ H NMR(CDCl₃) δ2.1 (m, 1H), 2.75 (m, 1H), 2.95 (m,2H), 3.71 (s,3H), 3.75 (d,1H, J=6Hz), 4.59 (d,1H, J=6Hz), 7.25 (m,2H), 7.57 (a,2H), 7.66 (d,2H), 7.94 (d,1H), 8.18 (d,1H).

Step F: 7-chloro-3,3a, 4,5-tetrahydro-3a-methoxycarbonyl-N-[4-(trifluoromethyl)phenyl]N-[N'-(methyl)-N'-(hexoxycarbonyl)aminosulfenyl]-2H-benz[g]indazole-2-carboxamide

To a suspension of the title compound of Step E above (2.2 g, 0.005 mol) in25 ml methylene chloride cooled to 0° C. was added triethylamine (1.0 g) and hexyl (chlorosulfenyl)(methyl)carbamate, (prepared in a mannersimilar to Example 1, Step D), (2.5 g 75% pure) dropwise at 0° C. The mixture was stirred at room temperature for additional one hour. The reaction mixture was concentrated under high vacuum and subjected to silica gel column chromatography using hexane-ether (1:1) as an eluent. The title compound (2.5 g) was obtained, melting point 128°-129° C. in high purity.

¹ H NMR (CDCl₃) δ0.87 (t,3H), 1.18 (m,8H), 1.9(m, 1H), 2.8 (m,3H), 3.5 (s,3H), 3.66 (s,3H), 3.7 (m,3H), 4.5 (d,1H), 7.05 (m,3H), 7.35(d,2H), 7.6 (d,2H).

Using the procedures described in Examples 1 to 4 with obvious modifications, the compounds exemplified in Examples 5 to 28 were prepared.

                                      TABLE A                                      __________________________________________________________________________      ##STR10##                                                                                                     .sup.1 H NMR (δ in ppm)                  Example                                                                             R.sub.2                                                                           Z                  m.p. °C.                                                                     in CDCl.sub.3                                  __________________________________________________________________________      5   H  N(CH.sub.3)C(O)OC.sub.4 H.sub.9                                                                   134  1.0(t, 3H), 1.2(m, 4H),                                                        1.9(m, 1H), 2.6-3(m, 3H),                                                      3.5(s, 3H), 3.66(s, 3H),                                                       3.7(m, 2H), 3.75(d, 1H),                                                       4.45(d, 1H), 7.1(m, 3H),                                                       7.25(m, 1H), 7.35(d, 2H),                                                      7.6(d, 2H).                                     6   H  N(CH.sub.3)C(O)OC.sub.2 H.sub.5                                                                   121-123                                                                             0.88(t, 3H), 1.9(m, 1H),                                                       2.6-3(m, 3H), 3.5(s, 3H),                                                      3.66 (s, 3H), 3.8(m, 3H),                                                      4.47(d, 1H), 7.11(m, 3H),                                                      7.25 (m, 1H), 7.35(d, 2H),                                                     7.6(d, 2H).                                     7   6-F                                                                               N(CH.sub.3)C(O)OC.sub.4 H.sub.9                                                                   120  0.83(t, 3H), 1.2(m, 4H),                                                       1.85(m, 1H), 2.7(m, 2H),                                                       3.0(m, 1H), 3.5(s, 3H),                                                        3.66(s, 3H), 3.75(m, 3H),                                                      4.5(d, 1H), 7.0(m, 3H),                                                        7.35(d, 2H), 7.6(d, 3H).                        8   H  N(CH.sub.3)C(O)OcycloC.sub.6 H.sub.11                                                             175-176                                                                             0.6-1.7(m, 10H), 1.9(m, 1H),                                                   2.6-3.0(m, 3H), 3.51(s, 3H),                                                   3.65(s, 3H), 3.75(d, 1H),                                                      4.35(m, 1H), 4.45 (d, 1H),                                                     7.1(m, 3H), 7.25(m, 1H),                                                       7.35(d, 2H), 7.6(d, 2H).                        9   H  N(CH.sub.3)C(O)OC.sub.8 H.sub.17                                                                  144-145                                                                             0.88(t, 3H), 1.21(m, 12H),                                                     1.9(m, 1H), 2.7(m, 1H),                                                        2.9(m, 2H), 3.5(m, 3H),                                                        3.65(m, 3H), 3.75(m, 3H),                                                      4.5(d, 1H), 7.1(m, 3H),                                                        7.25(m, 1H), 7.35(d, 2H),                                                      7.6(d, 2H).                                    10   H  N(CH.sub.3)C(O)OC.sub.10 H.sub.21                                                                 76-78                                                                               0.88(t, 3H), 1.25(m, 16H),                                                     1.9(m, 1H), 2.7(m, 1H),                                                        2.9(m, 2H), 3.5(s, 3H),                                                        3.66(s, 3H), 3.75(m, 3H),                                                      4.5(d, 1H), 7.15(m, 3H),                                                       7.25(m, 1H), 7.35(d, 2H),                                                      7.6 (d, 2H).                                   11   6-F                                                                               N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.2 H.sub.5                                                          143.5                                                                             0.91(t, 3H), 1.27(d, 3H),                                                      1.35(d, 3H), 1.9(m, 1H),                                                       2.75(m, 2H), 3.05(m, 1H),                                                      3.67(s, 3H), 3.75(m, 3H),                                                      4.5(m, 2H), 7.25(m, 3H),                                                       7.45(d, 2H), 7.6(d, 2H).                       12   H  N(CH.sub.3)C(O)OC.sub.12 H.sub.25                                                                 --   0.88(t, 3H), 1.26(m, 20H),                                                     1.9(m, 1H), 2.7(m, 1H),                                                        2.9(m, 2H), 3.5(s, 3H),                                                        3.66(s, 3H), 3.75(m, 3H),                                                      4.5(d, 1H), 7.1(m, 3H),                                                        7.25(m, 1H), 7.35(d, 2H),                                                      7.6(d, 2H).                                    13   H  N(CH.sub.3)C(O)OC.sub.6 H.sub.13                                                                  --   0.88(t, 3H), 1.26(m, 8H),                                                      1.9(m, 1H), 2.7(m, 1H),                                                        2.9(m, 2H), 3.51(s, 3H),                                                       3.66(s, 3H), 3.75(m, 3H),                                                      4.5(d, 2H), 7.1(m, 3H),                                                        7.25(m, 1H), 7.35(d, 2H),                                                      7.6(d, 2H).                                    14   7-Cl                                                                              C(O)O-sec-C.sub.4 H.sub.9                                                                         132  0.88(t, 3H), 1.3(m, 3H),                                                       1.6(m, 2H), 1.9(m, 1H),                                                        2.6-3.0(m, 3H), 3.88(s, 3H),                                                   3.8(d, 1H), 4.5(d, 1H),                                                        5.0(m, 1H), 7.0(m, 3H),                                                        7.35(d, 2H), 7.6(d, 2H).                       15   7-Cl                                                                              N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.2 H.sub.5                                                        152  0.9(t, 3H), 1.26(d, 3H),                                                       1.35(d, 3H), 1.9(m, 1H),                                                       2.7(m, 1H), 2.9(m, 2H),                                                        3.67(s, 3H), 3.8(m, 3H),                                                       4.5(m, 2H), 7.14(m, 2H),                                                       7.4(m, 3H), 7.6(d, 2H).                        16   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.2 H.sub.5                                                                   --   0.88(t, 3H), 1.9(m, 1H),                                                       2.65(m, 1H), 2.9(m, 2H),                                                       3.49(s, 3H), 3.66(s, 3H),                                                      3.8(m, 3H), 4.5(d, 1H),                                                        7.07(m, 3H), 7.35(d, 2H),                                                      7.6(d, 2H).                                    17   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.8 H.sub.17                                                                  103-106                                                                             0.88(t, 3H), 1.23(m, 12H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                       2.85(m, 2H), 3.5(s, 3H),                                                       3.66(s, 3H), 3.75(m, 3H),                                                      4.45(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       18   6-F                                                                               C(O)O-sec-C.sub.4 H.sub.9                                                                         125-126                                                                             0.9(m, 3H), 1.3(m, 5H),                                                        1.9(m, 1H), 2.75(m, 2H),                                                       3.0(m, 1H), 3.7(s, 3H),                                                        3.8(d, 1H), 4.5(d, 1H),                                                        5.0(m, 1H), 6.8(m, 1H),                                                        7.05(m, 2H), 7.45(d, 2H),                                                      7.6(d, 2H).                                    19   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.4 H.sub.9                                                                   125-127                                                                             0.82(m, 3H), 1.2(m, 4H),                                                       2.9(m, 1H), 2.65(m, 1H),                                                       2.85(m, 2H), 3.5(s, 3H),                                                       3.66(s, 3H), 3.75(m, 3H),                                                      4.45(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       20   7-Cl                                                                              N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.4 H.sub.9                                                        --   0.84(t, 3H), 1.25(m, 10H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                       3.66(s, 3H), 3.7(m, 3H),                                                       4.45(m, 2H), 7.15(m, 2H),                                                      7.4(m, 3H), 7.6(d, 2H).                        21   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.12 H.sub.25                                                                 --   0.88(t, 3H), 1.2(m, 20H),                                                      1.9(m, 1H), 2.65(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                        3.67(s, 3H), 3.75(m, 3H),                                                      4.5(d, 1H), 7.05(m, 3H),                                                       7.35(d, 2H), 7.6(d, 2H).                       22   7-Cl                                                                              N(CH.sub.3)C(O)O-cycloC.sub.6 H.sub.11                                                            87-91                                                                               0.8-1.7(Broad m, 10H),                                                         2.65(m, 1H), 2.9(m, 2H),                                                       3.51(s, 3H), 3.66(s, 3H),                                                      3.75(d, 1H), 4.35(m, 1H),                                                      4.45(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       23   7-Cl                                                                              N(CH.sub.3)C(O)O(CH.sub.2).sub.2 OC.sub.4 H.sub.9                                                 --   0.9 (t, 3H), 1.4 (m, 4H)                                                       1.9(m, 1H), 2.7(m, 1H)                                                         2.9(m, 2H), 3.3(m, 4H)                                                         3.5(s, 3H), 3.67(s, 3H),                                                       3.9(m, 3H), 4.5(d, 1H),                                                        7.1(m, 3H), 7.4(d, 2H),                                                        7.6(d, 2H).                                    24   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.14 H.sub.29                                                                 --   0.87(t, 3H), 1.26(m, 24H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                        3.68(s, 3H), 3.75(m, 3H),                                                      4.47(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.57(d, 2H).                      25   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.16 H.sub.33                                                                 --   0.87(t, 3H), 1.26(m, 28H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                        3.67(s, 3H), 3.75(m, 3H),                                                      4.47(d, 1H), 7.05(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       26   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.18 H.sub.37                                                                 --   0.9(t, 3H), 1.26(m, 32H),                                                      1.9(m, 1H), 2.65(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                        3.67(m, 3H), 3.75(m, 3H),                                                      4.5(d, 1H), 7.05(m, 3H),                                                       7.35(d, 2H), 7.6(d, 2H).                       27   7-Cl                                                                              N(CH.sub.3)C(O)OC.sub.22 H.sub.45                                                                 --   0.88(t, 3H), 1.26(m, 40H),                                                     1.9(m, 1H), 2.65(m, 1H),                                                       2.9(m, 2H), 3.5(s, 3H),                                                        3.65(m, 3H), 3.75(m, 3H),                                                      4.48(d, 1H), 7.06(m, 3H),                                                      7.35(d, 2H), 7.6(d, 2H).                       28   7-Cl                                                                              N(CH.sub.3)C(O)O(CH.sub.2 ).sub.2 O(CH.sub.2).sub.2 OC.sub.4                   H.sub.9            --   0.91(t, 3H), 1.4(m, 4H),                                                       1.9(m, 1H), 2.7(m, 1H),                                                        2.9(m, 2H), 3.5(s, 3H),                                                        3.67(s, 3H), 3.7(m, 9H).                                                       4.0(m, 1H), 4.2(m, 1H),                                                        4.5(d, 1H), 7.6(m, 3H),                                                        7.4(d, 2H), 7.6(d, 2H).                        __________________________________________________________________________

EXAMPLE 29

1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminothiol]-1H-pyrazole-3-carboxamide

Step A: Ethyl (chlorosulfenyl)(1-methylethyl)carbamate

To a solution of ethyl (1-methylethyl)carbamate (13.1 g, 0.1 mol) in 100 mlof methylene chloride cooled to 0° C. was added sulfur dichloride (11.3 g, 0.11 mol) in one portion. While maintaining the temperature of the mixture at 0° C., pyridine (8.7 g, 0.11 mol) was added dropwiseover eleven minutes. After complete addition of the pyridine the temperature was allowed to rise to room temperature and stirring was continued for additional 1.5 hours. The mixture was let stand overnight. Methylene chloride was evaporated under vacuum and 100 ml hexane was added. Filteration of pyridine in hydrochloride and evaporation of hexane resulted an orange oil which was distilled in a Kugelrohr apparatus to give 12.5 g of the title Compound B.P.: 64°-80° (bath temp.)

Step B: 1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminothiol]-1H-pyrazole-3-carboxamide

To a solution of 1-(4-chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide (0.95 g, 0.002 mol) in 10 ml of methylene chloride cooled to 0° C. was added triethylamine (0.25 g) followed by the title compound of Step A (0.5 g, 0.0025 mol). The reaction mixture was allowed to warm to room temperature with stirring for one hour. Methylene chloride (50 ml) was added and the mixture was washed with water, dried over magnesium sulfate and filtered. The solvent was evaporated and the residue was purified by silica gel column chromatographusing hexane:ether (2:1) as the eluent. Obtained 1.0 g of the title compound, m.p.: 136°-137° C.,

¹ H-NMR (CDCl₃); δ7.7 (d,2H), 7.4 (6, 2H), 7.0 (m, 6H), 6.3(d, 2H), 5.2 (d of d, 1H), 4.5 (m, 1H), 3.75 (m, 3H), 3.05 (d of d, 1H) 1.3(d of d, 6H), 0.87 (t, 3H).

EXAMPLE 30

3,4-bis-(4-chlorophenyl)-N-[4-(trifluoromethyl)phenyl]-N-[N'-(1-methylethyl)-N'-(ethoxycarbonyl)aminothiol]-4,5-dihydro-1H-pyrazole-1-carboxamide

To a solution of 3,4-bis-(4-chlorophenyl)-N[4-(trifluoromethyl)phenyl)]-4,5-dihydro-1H-pyrazole1-carboxamide (0.466 g, 0.001 mol) in 5 ml of methylene chloride cooledto 0° C. was added 0.3 g of triethylamine and ethyl (chlorosulfenyl)(1-methylethyl)carbamate (0.5 g). The mixture was allowed to warm to room temperature and let stand overnight. 20 ml CH₂ Cl₂ was added and the mixture was washed with water and dried over MgSO₄ and filtered. The solvent was evaporated under vacuum. The residue was purified by silica gel column chromatography using CH₂ Cl_(2:) Butylchloride mixture (1:1) as a primary eluent followed by ether. The title compound was obtained in high purity (0.28 g), m.p.: 65°-68° C.

¹ H-NMR (CDCl₃), δ7.65 (d, 2H), 7.5 (d, 2H), 7.27 (d, H), 7.17 (S, 4H), 7.0 (d, 2H), 4.6-4.3 (m, 3H), 3.95 (d of d, 1H), 3.8 (q, 2H), 1.3 (m, 6H), 0.95 (t, 3H).

The following additional Examples (Tables B and C) employed procedures similar to those described in the previous Examples 29 and 30 or in the disclosed literature.

                                      TABLE B                                      __________________________________________________________________________      ##STR11##                                                                                                 'H-NMR(δ in ppm)                             Example                                                                              X               m.p. °C.                                                                      in CDCl.sub.3                                      __________________________________________________________________________     31    N[CH(CH.sub.3).sub.2 ]C(O)OC.sub.4 H.sub.9                                                     165-170                                                                              7.23(d, 2H), 7.4(d, 2H),                                                       7.0(M, 6H), 6.3(d, 2H),                                                        5.2(d of d, 1H), 4.5                                                           (M, 1H), 3.75(M, 3H),                                                          3.1(d of d, 1H), 1.4-1.1                                                       (M, 10H), .85(t, 3H)                               32    N[CH(CH.sub.3)(C.sub.2 H.sub.5)]C(O)OC.sub.2 H.sub.5                                           --    7.23(d, 2H), 7.4(d, 2H),                                                       7.0(M, 6H), 6.3(d, 2H),                                                        5.2(d of d, 1H), 4.5                                                           (M, 1H), 3.75(M, 3H),                                                          3.1(d of d, 1H), 1.8-1.1                                                       (M, 5H), 0.9(M, 6H).                               33    C(O)OCH(CH.sub.3)(C.sub. 2 H.sub.5)                                                            159-161                                                                              7.25(d, 2H), 7.55(d, 2H),                                                      7.0(M, 6H), 6.25(d, 2H),                                                       5.2(d of d, 1H), 5.0                                                           (M, 1H), 3.75(d of d,                                                          1H), 3.1(d of d, 1H),                                                          1.65(m, 2H), 1.28(d,                                                           3H), 0.9(t, 3H).                                   34    N(CH.sub.3)C(O)O(cyclo C.sub.6 H.sub.11)                                                       147-150                                                                              7.2(d, 2H), 7.4(d, 2H),                                                        7.0(M, 6H), 6.3(d, 2H),                                                        5.2(d of d, 1H), 4.3                                                           (M, 1H), 3.7(d of d, 1H),                                                      3.5(5, 3H), 3.2(d of d,                                                        1H), 1.8-0.9(M, 10H).                              __________________________________________________________________________

                                      TABLE C                                      __________________________________________________________________________      ##STR12##                                                                     EX-                                                                            AMPLE                                                                               Q             R.sub.3                                                                          R.sub.1                                                                           m.p. °C.                                                                     'H-NMR (δ in ppm)                           __________________________________________________________________________     35   SN(CH.sub.3)C(O)O-sec-C.sub.4 H.sub.9                                                        Cl                                                                               CF.sub.3                                                                          83-84                                                                               7.8-6.9(m, 12H),                                                               4.6-4.3(M, 3H), 4.0                                                            (M, 3.H), 3.52(S, 3H),                                                         1.25(M, 2H), 1.0-0.7                                                           (M, 6H).                                          36   SC(O)O-sec-C.sub.4 H.sub.9                                                                   Cl                                                                               CF.sub.3                                                                          78-80                                                                               7.7-7.0(M, 12H), 5.0                                                           (M, 1H), 4.45(M, 2H),                                                          4.0(M, 1H), 1.6(M,                                                             2H), 1.3(d, 3H), 0.9                                                           (t, 3H).                                          37   SC(O)O-sec-C.sub.4 H.sub.9                                                                   Cl                                                                               Cl 66-69                                                                               7.4-6.9(m, 12H), 5.0                                                           (M, 1H), 4.5(M, 2H),                                                           4.0(M, 1H), 1.6(m,                                                             2H), 1.28(d, 3H), 0.9                                                          (M, 3H).                                          38   CO.sub.2 CH.sub.3                                                                            Cl                                                                               CF.sub.3                                                                          151-154                                                                             7.7-7.0(m, 12H), 4.7                                                           (d, d, 1H), 4.5(d, d, 1H),                                                     4.1(d, d, 1H), 3.86                                                            (s, 3H).                                          39   COCH.sub.3    F CF.sub.3                                                                          157-159                                                                             7.7-7.0(m, 12H), 4.7                                                           (d, d, 1H), 4.5(d, d, 1H),                                                     4.1(d, d, 1H), 3.86                                                            (s, 3H).                                          40   SN(CH(CH.sub.3).sub.2)SO.sub.2 C.sub.2 H.sub.5                                               Cl                                                                               CF.sub.3                                                                          oil  7.65(m, 2H), 7.25(m, 4H),                                                      7.05(m, 1H), 4.6-3.9                                                           (m, 3H), 3/65(m, 1H), 3.03                                                     (q, 2H), 1.36(t, 3H), 1.24                                                     (d, 6H).                                          41   COCH.sub.3    Cl                                                                               CF.sub.3                                                                          166-168                                                                             7.6-7.0(m, 12H),                                                               4.7-4.0(m, 3H),                                                                2.3(s, 3H).                                       42   COCH.sub.3    F Cl 187-190                                                                             7.5-7.0(m, 12H),                                                               4.6(m, 1H), 4.4                                                                (m, 1H), 4.0(m, 1H),                                                           2.26(s, 3H).                                      43   COCH.sub.3    F Br 181-186                                                                             7.6-7.0(m, 12H),                                                               4.65(m, 1H),                                                                   4.4(m, 1H),                                                                    4.0(m, 1H),                                                                    2.25(s, 3H).                                      44   CO.sub.2 Me   F CF.sub.3                                                                          80-86                                                  45   COPh          F CF.sub.3                                                                          176-179                                                46   COEt          Cl                                                                               CF.sub.3                                                                          169-170                                                47   EtCOCO        Cl                                                                               CF.sub.3                                                                          166-167                                                48   CO-n-Bu       Cl                                                                               CF.sub.3                                                                          60-62                                                  49   COCH.sub.3    Cl                                                                               Cl 205-206                                                50   COEt          Cl                                                                               Cl 157-158                                                51   CO.sub.2 Me   Cl                                                                               Cl 162-166                                                52   4-ClPhCO      Cl                                                                               CF.sub.3                                                                          209-211                                                53   t-BuCO        Cl                                                                               CF.sub.3                                                                          140-145                                                54   PhOCO         Cl                                                                               CF.sub.3                                                                          150-155                                                __________________________________________________________________________

EXAMPLE 55

N-acetyl-3,4-bis(4-chlorophenyl)-4,5-dihydro-N-[4-(trifluoromethyl)phenyl]-1H-pyrazole-1-carboxamide

The compound of Step D of Example 6 (0.65,g) was dissolved in tetrahydrofuran (20 ml) and treated with 60% sodium hydride in oil (0.12 g). After the evolution of hydrogen was complete (30 minutes), acetic anhydride (0.6 ml) was added and the mixture was stirred at room temperature for 16 hours. The reaction was diluted with saturated aqueous ammonium chloride solution (15 ml) and ethyl acetate (30 ml). The organic layer was dried with magnesium sulfate and evaporated. The residue was subjected to chromatography on silica gel with hexanes/ethyl acetate (3:1)as eluent. Addition of methanol (10 ml) to the product gave, after filtration, the title compound (0.4 g). m.p. 166° to 168° C.

NMR (CDCl₃) 7.6-7.0 (m, ArH, 12H), 4.7-4.0 (m, 3H, CH and CH₂), 2.3 (s, COCH₃, 3H).

                  TABLE 1                                                          ______________________________________                                          ##STR13##                                                                     R.sub.1                                                                               R.sub.2  B        R.sub.8                                                                               R.sub.9                                        ______________________________________                                         4-CF.sub.3                                                                            5-Cl     H        Me     OEt                                            4-CF.sub.3                                                                            5-Cl     Me       Me     OEt                                            4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     OEt                                            4-Cl   H        CO.sub.2 Me                                                                             Me     OEt                                            4-Br   H        CO.sub.2 Me                                                                             Me     OEt                                            4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     OEt                                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     OEt                                            4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     OEt                                            4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     OEt                                            4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     OEt                                            4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     OEt                                            4-CF.sub.3                                                                            5-Cl     Ph       Me     OEt                                            4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     OEt                                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     OEt                                            4-CF.sub.3                                                                            5-Cl     H        Me     O-n-Bu                                         4-CF.sub.3                                                                            4-F      H        Me     O-n-Bu                                         4-CF.sub.3                                                                            H        Me       Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     Me       Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Br     Me       Me     O-n-Bu                                         4-CF.sub.3                                                                            4-F      Me       Me     O-n-Bu                                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Cl   H        CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Br   H        CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Br   5-Cl     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Cl   5-Br     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Br   5-Br     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Cl   4-F      CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-Br   4-F      CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     Ph       Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     Me       Me     O-n-hexyl                                      4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Cl   H        CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Br   H        CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Br   5-Cl     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Br   5-Br     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Cl   4-F      CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-Br   4-F      CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-Cl     Ph       Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     O-n-hexyl                                      4-CF.sub.3                                                                            5-Cl     Me       Me     O-n-octyl                                      4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Cl   H        CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Br   H        CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Br   5-Cl     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Br   5-Br     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Cl   4-F      CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-Br   4-F      CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            5-Cl     Ph       Me     O-n-octyl                                      4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     O-n-octyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     O-n-octyl                                      4-CF.sub.3                                                                            5-Cl     Me       Me     O-n-decyl                                      4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Cl   H        CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Br   H        CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Br   5-Cl     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Br   5-Br     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Cl   4-F      CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-Br   4-F      CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            5-Cl     Ph       Me     O-n-decyl                                      4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     O-n-decyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     O-n-decyl                                      4-CF.sub.3                                                                            5-Cl     Me       Me     O-n-dodecyl                                    4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Cl   H        CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Br   H        CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Br   5-Cl     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Cl   5-Br     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Br   5-Br     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Cl   4-F      CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-Br   4-F      CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-Cl     Ph       Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     O-n-dodecyl                                    4-CF.sub.3                                                                            5-Cl     Me       Me     O-sec-Bu                                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Cl   H        CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Br   H        CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Br   5-Cl     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Cl   5-Br     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Br   5-Br     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Cl   4-F      CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-Br   4-F      CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-Cl     Ph       Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     O-sec-Bu                                       4-CF.sub.3                                                                            5-Cl     Me       Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Cl   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Br   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Br   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Cl   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Br   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Cl   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-Br   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-Cl     Ph       Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3                                                                            5-Cl     Me       Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Cl   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Br   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Br   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Cl   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Br   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-OCF.sub. 3                                                                          5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Cl   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-Br   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-Cl     Ph       Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            5-Cl     Me       Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Cl   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Br   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Br   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Cl   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Br   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Cl   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-Br   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-Cl     Ph       Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     OCH.sub.2 CF.sub.3                             4-CF.sub.3                                                                            5-Cl     Me       Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Cl   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Br   H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Br   5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Cl   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Br   5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Cl   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-Br   4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-Cl     Ph       Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            H        H        Me     F                                              4-CF.sub.3                                                                            5-Cl     H        Me     F                                              4-CF.sub. 3                                                                           5-Br     H        Me     F                                              4-CF.sub.3                                                                            4-F      H        Me     F                                              4-CF.sub.3                                                                            H        Me       Me     F                                              4-CF.sub.3                                                                            5-Cl     Me       Me     F                                              4-CF.sub.3                                                                            5-Br     Me       Me     F                                              4-CF.sub.3                                                                            4-F      Me       Me     F                                              4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Me     F                                              4-Cl   H        CO.sub.2 Me                                                                             Me     F                                              4-Br   H        CO.sub.2 Me                                                                             Me     F                                              4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Me     F                                              4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     F                                              4-Cl   5-Cl     CO.sub.2 Me                                                                             Me     F                                              4-Br   5-Cl     CO.sub.2 Me                                                                             Me     F                                              4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     F                                              4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     F                                              4-Cl   5-Br     CO.sub.2 Me                                                                             Me     F                                              4-Br   5-Br     CO.sub.2 Me                                                                             Me     F                                              4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     F                                              4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     F                                              4-Cl   4-F      CO.sub.2 Me                                                                             Me     F                                              4-Br   4-F      CO.sub.2 Me                                                                             Me     F                                              4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     F                                              4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             Me     F                                              4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             Me     F                                              4-CF.sub.3                                                                            5-Cl     Ph       Me     F                                              4-CF.sub.3                                                                            5-Cl     4-ClPh   Me     F                                              4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             Me     F                                              4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     piperidino                                     4-CF.sub.3                                                                            4-F      Me       Me     piperidino                                     4-CF.sub.3                                                                            Cl       CO.sub.2 Me                                                                             Me     morpholino                                     4-OCF.sub.3                                                                           Cl       CO.sub.2 Me                                                                             Me     morpholino                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     n-Pr                                           4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Me     n-Pr                                           4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             Me     sec-Bu                                         4-Cl   5-Br     CO.sub.2 Me                                                                             Me     sec-Bu                                         4-Br   5-Br     CO.sub.2 Me                                                                             Me     sec-Bu                                         4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             Me     sec-Bu                                         4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             Me     4-ClPh                                         4-Cl   4-F      CO.sub.2 Me                                                                             Me     4-ClPh                                         4-Br   4-F      CO.sub.2 Me                                                                             Me     4-ClPh                                         4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             Me     4-ClPh                                         4-CF.sub.3                                                                            5-Cl     Me       Et     OCH.sub.2 CCl.sub.3                            4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             Et     NEt.sub.2                                      4-Cl   H        CO.sub.2 Me                                                                             Et     NEt.sub.2                                      4-Br   H        CO.sub.2 Me                                                                             Et     NEt.sub.2                                      4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             Et     NEt.sub.2                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Et     2,6-di-Me-morpholino                           4-Cl   5-Cl     CO.sub.2 Me                                                                             Et     2,6-di-Me-morpholino                           4-Br   5-Cl     CO.sub.2 Me                                                                             Et     2,6-di-Me-morpholino                           4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             Et     2,6-di-Me-morpholino                           4-CF.sub.3                                                                            5-Cl     Me       iPr    OEt                                            4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    OEt                                            4-Cl   H        CO.sub.2 Me                                                                             iPr    OEt                                            4-Br   H        CO.sub. 2 Me                                                                            iPr    OEt                                            4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             iPr    OEt                                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    OEt                                            4-Cl   5-Cl     CO.sub.2 Me                                                                             iPr    OEt                                            4-Br   5-Cl     CO.sub.2 Me                                                                             iPr    OEt                                            4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             iPr    OEt                                            4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             iPr    OEt                                            4-Cl   5-Br     CO.sub.2 Me                                                                             iPr    OEt                                            4-Br   5-Br     CO.sub.2 Me                                                                             iPr    OEt                                            4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    OEt                                            4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    OEt                                            4-Cl   4-F      CO.sub.2 Me                                                                             iPr    OEt                                            4-Br   4-F      CO.sub.2 Me                                                                             iPr    OEt                                            4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    OEt                                            4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             iPr    OEt                                            4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             iPr    OEt                                            4-CF.sub.3                                                                            5-Cl     Ph       iPr    OEt                                            4-CF.sub.3                                                                            5-Cl     4-ClPh   iPr    OEt                                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             iPr    OEt                                            4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     ON(CH.sub.3)SCH.sub.3                          4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     2,3-dihydro-2,2-                                                               dimethylbenzofuranyl                                                           oxy-7                                          4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             Me     1-naphthoxy                                    4-CF.sub.3                                                                            5-Cl     Me       iPr    O-n-Bu                                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Cl   H        CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Br   H        CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Cl   5-Cl     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Br   5-Cl     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Cl   5-Br     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Br   5-Br     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Cl   4-F      CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-Br   4-F      CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     Ph       iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     4-ClPh   iPr    O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             iPr    O-n-Bu                                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             iPr    OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    OCH.sub.2 CO.sub.2 Me                          4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    NMe.sub.2                                      4-Cl   H        CO.sub.2 Me                                                                             iPr    NMe.sub.2                                      4-Br   H        CO.sub.2 Me                                                                             iPr    NMe.sub.2                                      4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             iPr    NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    NEt.sub.2                                      4-Cl   5-Cl     CO.sub.2 Me                                                                             iPr    NEt.sub.2                                      4-Br   5-Cl     CO.sub.2 Me                                                                             iPr    NEt.sub.2                                      4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             iPr    NEt.sub.2                                      4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             iPr    piperidino                                     4-Cl   5-Br     CO.sub.2 Me                                                                             iPr    piperidino                                     4-Br   5-Br     CO.sub.2 Me                                                                             iPr    piperidino                                     4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    piperidino                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    Et                                             4-Cl   4-F      CO.sub.2 Me                                                                             iPr    Et                                             4-Br   4-F      CO.sub.2 Me                                                                             iPr    Et                                             4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    Et                                             4-CF.sub.3                                                                            H        H        CH.sub.2 Ph                                                                           OEt                                            4-CF.sub.3                                                                            5-Cl     H        CH.sub.2 Ph                                                                           O-n-octyl                                      4-CF.sub.3                                                                            5-Br     H        CH.sub.2 Ph                                                                           OCH.sub.2 CO.sub.2 Et                          4-CF.sub.3                                                                            H        Me       CH.sub.2 Ph                                                                           NEt.sub.2                                      4-CF.sub.3                                                                            5-Cl     Me       CH.sub.2 Ph                                                                           morpholino                                     4-CF.sub.3                                                                            5-Br     Me       CH.sub.2 Ph                                                                           4-ClPh                                         4-CF.sub.3                                                                            4-F      Me       CH.sub.2 Ph                                                                           Et                                             4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           O-n-Bu                                         4-Cl   H        CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           O-iPr                                          4-Br   H        CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           OCH.sub.2 CF.sub.3                             4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           NMe.sub.2                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           piperidino                                     4-Cl   5-Cl     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           Ph                                             4-Br   5-Cl     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           4-NO.sub.2Ph                                   4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           Bu                                             4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           O-n-hexyl                                      4-Cl   5-Br     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           O-sec-Bu                                       4-Br   5-Br     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           OCH.sub.2 CH.sub.2 OEt                         4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           NMe.sub.2                                      4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           2,6-di-Me-morpholino                           4-Cl   4-F      CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           3-BrPh                                         4-Br   4-F      CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           4-MePh                                         4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           nPr                                            4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           Me                                             4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                           OEt                                            4-CF.sub.3                                                                            5-Cl     Ph       CH.sub.2 Ph                                                                           O-n-Bu                                         4-CF.sub.3                                                                            5-Cl     4-ClPh   CH.sub.2 Ph                                                                           O-n-octyl                                      4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             CH.sub.2 Ph                                                                           OCH.sub.2 CCl.sub.3                            ______________________________________                                    

                  TABLE 2                                                          ______________________________________                                          ##STR14##                                                                     R.sub.1 R.sub.2 B         R.sub.8                                                                             R.sub.9                                         ______________________________________                                         4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Cl    H       CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Br    H       CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Cl    5-Cl    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Br    5-Cl    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Cl    5-Br    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Br    5-Br    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Cl    4-F     CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-Br    4-F     CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    Ph        Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    4-ClPh    Me   NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              Me   NMe.sub.2                                       4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Cl    H       CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Br    H       CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Cl    5-Cl    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Br    5-Cl    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Cl    5-Br    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Br    5-Br    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              Me   NEt.sub.2                                       4-Cl    4-F     CO.sub.2 Me                                                                              Me   piperidino                                      4-Br    4-F     CO.sub.2 Me                                                                              Me   piperidino                                      4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              Me   piperidino                                      4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              Me   piperidino                                      4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              Me   piperidino                                      4-CF.sub.3                                                                             5-Cl    Ph        Me   piperidino                                      4-CF.sub.3                                                                             5-Cl    4-ClPh    Me   piperidino                                      4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              Me   piperidino                                      4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              Me   C.sub.2 H.sub.5                                 4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Me   C.sub.2 H.sub.5                                 4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              Me   C.sub.2 H.sub.5                                 4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              Me   C.sub.2 H.sub.5                                 4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              Me   n-hexyl                                         4-Cl    H       CO.sub.2 Me                                                                              Me   n-hexyl                                         4-Br    H       CO.sub.2 Me                                                                              Me   n-hexyl                                         4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              Me   n-hexyl                                         4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Me   Ph                                              4-Cl    5-Cl    CO.sub.2 Me                                                                              Me   Ph                                              4-Br    5-Cl    CO.sub.2 Me                                                                              Me   Ph                                              4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Me   Ph                                              4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              Me   4-ClPh                                          4-Cl    5-Br    CO.sub.2 Me                                                                              Me   4-ClPh                                          4-Br    5-Br    CO.sub.2 Me                                                                              Me   4-ClPh                                          4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              Me   4-ClPh                                          4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              Me   4-MePh                                          4-Cl    4-F     CO.sub.2 Me                                                                              Me   4-MePh                                          4-Br    4-F     CO.sub.2 Me                                                                              Me   4-MePh                                          4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              Me   4-MePh                                          4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              Me   n-Bu                                            4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              Me   n-Bu                                            4-CF.sub.3                                                                             5-Cl    Ph        Me   n-Bu                                            4-CF.sub.3                                                                             5-Cl    4-ClPh    Me   n-Bu                                            4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              Me   n-Bu                                            4-CF.sub.3                                                                             H       H         Et   NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    H         Et   NMe.sub.2                                       4-CF.sub.3                                                                             5-Br    H         Et   NMe.sub.2                                       4-CF.sub.3                                                                             4-F     H         Et   NMe.sub.2                                       4-CF.sub.3                                                                             H       Me        Et   NEt.sub.2                                       4-CF.sub.3                                                                             5-Cl    Me        Et   NEt.sub.2                                       4-CF.sub.3                                                                             5-Br    Me        Et   NEt.sub.2                                       4-CF.sub.3                                                                             4-F     Me        Et   NEt.sub.2                                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Et   morpholino                                      4-Cl    5-Cl    CO.sub.2 Me                                                                              Et   morpholino                                      4-Br    5-Cl    CO.sub.2 Me                                                                              Et   morpholino                                      4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Et   morpholino                                      4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Et   iPr                                             4-Cl    5-Cl    CO.sub.2 Me                                                                              Et   iPr                                             4-Br    5-Cl    CO.sub.2 Me                                                                              Et   iPr                                             4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Et   iPr                                             4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              Et   n-Bu                                            4-Cl    5-Br    CO.sub.2 Me                                                                              Et   n-Bu                                            4-Br    5-Br    CO.sub.2 Me                                                                              Et   n-Bu                                            4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              Et   n-Bu                                            4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              Et   Ph                                              4-Cl    4-F     CO.sub.2 Me                                                                              Et   Ph                                              4-Br    4-F     CO.sub.2 Me                                                                              Et   Ph                                              4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              Et   Ph                                              4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Cl    H       CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Br    H       CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Cl    5-Cl    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Br    5-Cl    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Cl    5-Br    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Br    5-Br    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Cl    4-F     CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-Br    4-F     CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              iPr  NMe.sub.2                                       4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              iPr  NMe.sub. 2                                      4-CF.sub.3                                                                             5-Cl    Ph        iPr  NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    4-ClPh    iPr  NMe.sub.2                                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              iPr  NMe.sub.2                                       4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              iPr  2,6-di-Me-morpholino                            4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              iPr  2,6-di-Me-morpholino                            4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              iPr  2,6-di-Me-morpholino                            4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              iPr  2,6-di-Me-morpholino                            4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              iPr  piperidino                                      4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              iPr  piperidino                                      4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              iPr  Et                                              4-Cl    5-Cl    CO.sub.2 Me                                                                              iPr  Et                                              4-Br    5-Cl    CO.sub.2 Me                                                                              iPr  Et                                              4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              iPr  Et                                              4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              iPr  n-Bu                                            4-Cl    5-Br    CO.sub.2 Me                                                                              iPr  n-Bu                                            4-Br    5-Br    CO.sub.2 Me                                                                              iPr  n-Bu                                            4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              iPr  n-Bu                                            4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              iPr  Ph                                              4-Cl    4-F     CO.sub.2 Me                                                                              iPr  Ph                                              4-Br    4-F     CO.sub.2 Me                                                                              iPr  Ph                                              4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              iPr  Ph                                              4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              iPr  4-ClPh                                          4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              iPr  4-ClPh                                          4-CF.sub.3                                                                             5-Cl    Ph        iPr  4-ClPh                                          4-CF.sub.3                                                                             5-Cl    4-ClPh    iPr  4-ClPh                                          4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              iPr  4-ClPh                                          ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                          ##STR15##                                                                     R.sub.1                                                                               R.sub.2 B         R.sub.8                                                                             Y'   Y'R.sub.10                                                                            Y'R.sub.11                           ______________________________________                                         4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Cl   H       CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Br   H       CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Cl   5-Cl    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Br   5-Cl    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Cl   5-Br    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Br   5-Br    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Cl   4-F     CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-Br   4-F     CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub. 2 C(Me).sub.2 CH.sub.2 O           4-Cl   5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    Ph        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Cl   H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Br   H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Cl   5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Br   5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Cl   5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Br   5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Cl   4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-Br   4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-Cl    Ph        tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Cl   H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Br   H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Cl   5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Br   5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Cl   5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Br   5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Cl   4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-Br   4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-Cl    Ph        tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Cl   H       CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Br   H       CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Cl   5-Cl    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Br   5-Cl    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Cl   5-Br    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Br   5-Br    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Cl   4-F     CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-Br   4-F     CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   H       CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   H       CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   5-Cl    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   5-Cl    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   5-Br    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   5-Br    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   4-F     CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   4-F     CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    Ph        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF   5-Cl    4-ClPh    iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Cl   H       CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Br   H       CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Cl   5-Cl    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Br   5-Cl    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-OCF.sub.3                                                                           5-Cl    CO.sub. 2 Me                                                                             Me   S    OEt    OEt                                  4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Cl   5-Br    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Br   5-Br    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Cl   4-F     CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-Br   4-F     CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              Me   S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        Me   S    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    Me   S    OEt    OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Cl   H       CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Br   H       CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Cl   5-Cl    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Br   5-Cl    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-Br    CO.sub. 2 Me                                                                             tBu  O    OEt    OEt                                  4-Cl   5-Br    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Br   5-Br    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Cl   4-F     CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-Br   4-F     CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    Ph        tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   H       CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   H       CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           H       CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   5-Cl    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   5-Cl    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           5-Cl    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   5-Br    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   5-Br    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   4-F     CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   4-F     CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F     CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    Ph        tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub. 2 O           4-CF.sub.3                                                                            5-Cl    4-ClPh    tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            5-Cl    CO.sub.2 Et                                                                              tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2              ______________________________________                                                                            O                                      

                  TABLE 4                                                          ______________________________________                                          ##STR16##                                                                     R.sub.1                                                                               R.sub.2  B        R.sub.8                                                                               Y'  R.sub.10                                                                             Y'R.sub.11                           ______________________________________                                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Cl   H        CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Br   H        CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Cl   5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Br   5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-CF.sub. 3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Cl   5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Br   5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Cl   4-F      CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-Br   4-F      CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             iPr    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     Ph       iPr    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     4-ClPh   iPr    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             iPr    O   Et    OEt                                  4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Cl   H        CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Br   H        CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Cl   5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Br   5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-OCF.sub.3                                                                           5-Cl     CO.sub.3 Me                                                                             iPr    O   Et    O-iPr                                4-CF.sub. 3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Cl   5-Br     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Br   5-Br     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Cl   4-F      CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-Br   4-F      CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     Ph       iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     4-ClPh   iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             iPr    O   Et    O-iPr                                4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Cl   H        CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Br   H        CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Cl   5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Br   5-Cl     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-CF.sub. 3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Cl   5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Br   5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Cl   4-F      CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-Br   4-F      CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             iPr    O   Et    OPh                                  4-CF.sub.3                                                                            5-Cl     Ph       iPr    O   Et    OPh                                  4-CF.sub.3                                                                            5-Cl     4-ClPh   iPr    O   Et    OPh                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             iPr    O   Et    OPh                                  4-Br   4-F      CO.sub.2 Me                                                                             iPr    O   Ph    OEt                                  4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    O   Ph    OEt                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             iPr    O   Ph    OEt                                  4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             iPr    O   Ph    OEt                                  4-CF.sub.3                                                                            5-Cl     Ph       iPr    O   Ph    OEt                                  4-CF.sub.3                                                                            5-Cl     4-ClPh   iPr    O   Ph    OEt                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             iPr    O   Ph    OEt                                  4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Cl   H        CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Br   H        CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Cl   5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Br   5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Cl   5-Br     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Br   5-Br     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Cl   4-F      CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-Br   4-F      CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            5-CF     CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     Ph       tBu    O   Et    OEt                                  4-CF   5-Cl     4-ClPh   tBu    O   Et    OEt                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             tBu    O   Et    OEt                                  4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Cl   H        CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Br   H        CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Cl   5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Br   5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-OCF.sub.3                                                                           5-Cl     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Cl   5-Br     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Br   5-Br     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Cl   4-F      CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-Br   4-F      CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     Ph       tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     4-ClPh   tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             tBu    O   Et    O-iPr                                4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             tBu    S   Et    OPh                                  4-Cl   H        CO.sub.2 Me                                                                             tBu    S   Ph    OEt                                  4-Br   H        CO.sub.2 Me                                                                             tBu    S   Ph    O-iPr                                4-OCF.sub.3                                                                           H        CO.sub.2 Me                                                                             tBu    S   Ph    OPh                                  4-Br   5-Br     CO.sub.2 Me                                                                             iPr    S   iPr   OEt                                  4-OCF.sub.3                                                                           5-Br     CO.sub.2 Me                                                                             iPr    S   iPr   O-iPr                                4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             iPr    S   iPr   OPh                                  4-Cl   4-F      CO.sub.2 Me                                                                             iPr    S   nPr   OEt                                  4-Br   4-F      CO.sub.2 Me                                                                             iPr    S   nPr   O-iPr                                4-OCF.sub.3                                                                           4-F      CO.sub.2 Me                                                                             iPr    S   nPr   OPh                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             tBu    S   Me    OEt                                  4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             tBu    S   Me    O-iPr                                4-CF.sub.3                                                                            5-Cl     Ph       tBu    S   Me    OPh                                  4-CF.sub.3                                                                            5-Cl     4-ClPh   tBu    S   Me    O-sec-Bu                             4-CF.sub.3                                                                            5-Cl     CO.sub.2 Et                                                                             tBu    S   Me    O-nPr                                ______________________________________                                    

                  TABLE 5                                                          ______________________________________                                          ##STR17##                                                                     R.sub.1    R.sub.2   B          R.sub.10                                                                              R.sub.11                                ______________________________________                                         4-CF.sub.3 H         CO.sub.2 Me                                                                               Et     Et                                      4-Cl       H         CO.sub.2 Me                                                                               Et     Et                                      4-Br       H         CO.sub.2 Me                                                                               Et     Et                                      4-OCF.sub.3                                                                               H         CO.sub.2 Me                                                                               Et     Et                                      4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               Et     Et                                      4-Cl       5-Cl      CO.sub.2 Me                                                                               Et     Et                                      4-Br       5-Cl      CO.sub.2 Me                                                                               Et     Et                                      4-OCF.sub.3                                                                               5-Cl      CO.sub.2 Me                                                                               Et     Et                                      4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               Et     Et                                      4-Cl       5-Br      CO.sub.2 ME                                                                               Et     Et                                      4-Br       5-Br      CO.sub.2 Me                                                                               Et     Et                                      4-OCF.sub.3                                                                               5-Br      CO.sub.2 Me                                                                               Et     Et                                      4-CF.sub.3 4-F       CO.sub. 2 Me                                                                              Et     Et                                      4-Cl       4-F       CO.sub.2 Me                                                                               Et     Et                                      4-Br       4-F       CO.sub.2 Me                                                                               Et     Et                                      4-OCF.sub.3                                                                               4-F       CO.sub.2 Me                                                                               Et     Et                                      4-CF.sub.3 5-CF.sub.3                                                                               CO.sub.2 Me                                                                               Et     Et                                      4-CF.sub.3 5-F       CO.sub.2 Me                                                                               Et     Et                                      4-CF.sub.3 5-Cl      Ph         Et     Et                                      4-CF.sub.3 5-Cl      4-ClPh     Et     Et                                      4-CF.sub.3 5-Cl      CO.sub.2 Et                                                                               Et     Et                                      4-CF.sub.3 5-Cl      Ph         Ph     Ph                                      4-CF.sub.3 5-Cl      4-ClPh     Ph     Ph                                      4-CF.sub.3 5-Cl      CO.sub.2 Et                                                                               Ph     Ph                                      ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR18##                                                                     R.sub.1 R.sub.2 B         R.sub.8 R.sub.12                                     ______________________________________                                         4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              nBu     nBu                                          4-Cl    H       CO.sub.2 Me                                                                              nBu     nBu                                          4-Br    H       CO.sub.2 Me                                                                              nBu     nBu                                          4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              nBu     nBu                                          4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              nBu     nBu                                          4-Cl    5-Cl    CO.sub.2 Me                                                                              nBu     nBu                                          4-Br    5-Cl    CO.sub.2 Me                                                                              nBu     nBu                                          4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              nBu     nBu                                          4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              nBu     nBu                                          4-Cl    5-Br    CO.sub.2 Me                                                                              nBu     nBu                                          4-Br    5-Br    CO.sub.2 Me                                                                              nBu     nBu                                          4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              nBu     nBu                                          4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              nBu     nBu                                          4-Cl    4-F     CO.sub.2 Me                                                                              nBu     nBu                                          4-Br    4-F     CO.sub.2 Me                                                                              nBu     nBu                                          4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              nBu     nBu                                          4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              nBu     nBu                                          4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              nBu     nBu                                          4-CF.sub.3                                                                             5-Cl    Ph        nBu     nBu                                          4-CF.sub.3                                                                             5-Cl    4-ClPh    nBu     nBu                                          4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              nBu     nBu                                          4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Cl    H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Br    H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Cl    5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Br    5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub. 2 CH.sub.2 CH.sub.2        4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Cl    5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Br    5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Cl    4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-Br    4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             5-Cl    Ph        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub. 3                                                                            5-Cl    4-ClPh    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2         4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Cl    H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Br    H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Cl    5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Br    5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Cl    5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Br    5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub. 2 CH.sub.2                4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Cl    4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-Br    4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF    5-CF    CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             5-Cl    Ph        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             5-Cl    4-ClPh    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                 4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Cl    H       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Br    H       CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              CH.sub. 2 CHMeOCHMeCH.sub.2                          4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Cl    5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Br    5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Cl    5-Br    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Br    5-Br    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Cl    4-F     CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-Br    4-F     CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             5-Cl    Ph        CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             5-Cl    4-ClPh    CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              CH.sub.2 CHMeOCHMeCH.sub.2                           4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Cl    H       CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Br    H       CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Cl    5-Cl    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Br    5-Cl    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Cl    5-Br    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Br    5-Br    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Cl    4-F     CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-Br    4-F     CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-Cl    Ph        Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-Cl    4-ClPh    Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              Et      cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                             H       CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Cl    H       CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Br    H       CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-OCF.sub.3                                                                            H       CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-Cl    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Cl    5-Cl    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Br    5-Cl    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-OCF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-Br    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Cl    5-Br    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Br    5-Br    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-OCF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             4-F     CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub. 2 Et               4-Cl    4-F     CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-Br    4-F     CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-OCF.sub.3                                                                            4-F     CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-CF.sub.3                                                                             CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-F     CO.sub.2 Me                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-Cl    Ph        iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-Cl    4-ClPh    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                             5-Cl    CO.sub.2 Et                                                                              iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et                ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                          ##STR19##                                                                     R.sub.1     R.sub.2   B          R.sub.10                                      ______________________________________                                         4-CF.sub.3  H         CO.sub.2 Me                                                                               tBu                                           4-Cl        H         CO.sub.2 Me                                                                               tBu                                           4-Br        H         CO.sub.2 Me                                                                               tBu                                           4-OCF.sub.3 H         CO.sub.2 Me                                                                               tBu                                           4-CF.sub.3  5-Cl      CO.sub.2 Me                                                                               tBu                                           4-Cl        5-Cl      CO.sub.2 ME                                                                               tBu                                           4-Br        5-Cl      CO.sub.2 Me                                                                               tBu                                           4-OCF.sub.3 5-Cl      CO.sub.2 Me                                                                               tBu                                           4-CF.sub.3  5-Br      CO.sub.2 Me                                                                               tBu                                           4-Cl        5-Br      CO.sub.2 Me                                                                               tBu                                           4-Br        5-Br      CO.sub.2 Me                                                                               tBu                                           4-OCF.sub.3 5-Br      CO.sub.2 Me                                                                               tBu                                           4-CF.sub.3  4-F       CO.sub.2 Me                                                                               tBu                                           4-Cl        4-F       CO.sub.2 Me                                                                               tBu                                           4-Br        4-F       CO.sub.2 Me                                                                               tBu                                           4-OCF.sub.3 4-F       CO.sub.2 Me                                                                               tBu                                           4-CF.sub. 3 5-CF.sub.3                                                                               CO.sub.2 Me                                                                               tBu                                           4-CF.sub.3  5-F       CO.sub.2 Me                                                                               tBu                                           4-CF.sub.3  5-Cl      Ph         tBu                                           4-CF.sub.3  5-Cl      4-ClPh     tBu                                           4-CF.sub.3  5-Cl      CO.sub.2 Et                                                                               tBu                                           4-CF.sub.3  H         CO.sub.2 Me                                                                               Ph                                            4-Cl        H         CO.sub.2 Me                                                                               Ph                                            4-Br        H         CO.sub.2 Me                                                                               Ph                                            4-OCF.sub.3 H         CO.sub.2 Me                                                                               Ph                                            4-CF.sub.3  5-Cl      CO.sub.2 Me                                                                               Ph                                            4-Cl        5-Cl      CO.sub.2 Me                                                                               Ph                                            4-Br        5-Cl      CO.sub.2 Me                                                                               Ph                                            4-OCF.sub.3 5-Cl      CO.sub.2 Me                                                                               Ph                                            4-CF.sub.3  5-Br      CO.sub.2 Me                                                                               Ph                                            4-Cl        5-Br      CO.sub.2 Me                                                                               Ph                                            4-Br        5-Br      CO.sub.2 Me                                                                               Ph                                            4-OCF.sub.3 5-Br      CO.sub.2 Me                                                                               Ph                                            4-CF.sub.3  4-F       CO.sub.2 Me                                                                               Ph                                            4-Cl        4-F       CO.sub.2 Me                                                                               Ph                                            4-Br        4-F       CO.sub.2 Me                                                                               Ph                                            4-OCF.sub.3 4-F       CO.sub.2 Me                                                                               Ph                                            4-CF.sub.3  5-CF.sub.3                                                                               CO.sub.2 Me                                                                               Ph                                            4-CF.sub.3  5-F       CO.sub.2 Me                                                                               Ph                                            4-CF.sub.3  5-Cl      Ph         Ph                                            4-CF.sub.3  5-Cl      4-ClPh     Ph                                            4-CF.sub.3  5-Cl      CO.sub.2 Et                                                                               Ph                                            4-CF.sub.3  H         CO.sub.2 Me                                                                               4-ClPh                                        4-Cl        H         CO.sub.2 Me                                                                               4-ClPh                                        4-Br        H         CO.sub.2 Me                                                                               4-ClPh                                        4-OCF.sub.3 H         CO.sub.2 Me                                                                               4-ClPh                                        4-CF.sub. 3 5-Cl      CO.sub.2 Me                                                                               4-ClPh                                        4-Cl        5-Cl      CO.sub.2 Me                                                                               4-ClPh                                        4-Br        5-Cl      CO.sub.2 Me                                                                               4-ClPh                                        4-OCF.sub.3 5-Cl      CO.sub.2 Me                                                                               4-ClPh                                        4-CF.sub.3  5-Br      CO.sub.2 Me                                                                               4-ClPh                                        4-Cl        5-Br      CO.sub.2 Me                                                                               4-ClPh                                        4-Br        5-Br      CO.sub.2 Me                                                                               4-ClPh                                        4-OCF.sub.3 5-Br      CO.sub.2 Me                                                                               4-ClPh                                        4-CF.sub.3  4-F       CO.sub.2 Me                                                                               4-ClPh                                        4-Cl        4-F       CO.sub.2 Me                                                                               4-ClPh                                        4-Br        4-F       CO.sub.2 Me                                                                               4-ClPh                                        4-OCF.sub.3 4-F       CO.sub.2 Me                                                                               4-ClPh                                        4-CF.sub.3  5-CF.sub.3                                                                               CO.sub.2 Me                                                                               4-ClPh                                        4-CF.sub.3  5-F       CO.sub.2 Me                                                                               4-ClPh                                        ______________________________________                                    

                  TABLE 8                                                          ______________________________________                                          ##STR20##                                                                     R.sub.1                                                                               R.sub.2  B        V     R.sub.8                                                                              R.sub.9                                   ______________________________________                                         4-CF.sub.3                                                                            5-Br     H        O     Me    OEt                                       4-Cl   5-Br     H        O     Me    OEt                                       4-Br   5-Br     H        O     Me    OEt                                       4-OCF.sub.3                                                                           5-Br     H        O     Me    OEt                                       4-CF.sub.3                                                                            5-Cl     H        O     Me    OEt                                       4-Cl   5-Cl     H        O     Me    OEt                                       4-Br   5-Cl     H        O     Me    OEt                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    OEt                                       4-CF.sub.3                                                                            4-F      H        O     Me    OEt                                       4-CF.sub.3                                                                            H        H        O     Me    OEt                                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    OEt                                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    OEt                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    OEt                                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    OEt                                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    OEt                                       4-CF.sub.3                                                                            5-Cl     H        S     Me    OEt                                       4-Cl   5-Cl     H        S     Me    OEt                                       4-Br   5-Cl     H        S     Me    OEt                                       4-CF.sub.3                                                                            5-Br     H        S     Me    OEt                                       4-CF.sub.3                                                                            5-F      H        S     Me    OEt                                       4-CF.sub.3                                                                            4-Cl     H        S     Me    OEt                                       4-CF.sub.3                                                                            4-F      H        S     Me    OEt                                       4-CF.sub.3                                                                            H        H        S     Me    OEt                                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    OEt                                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    OEt                                       4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    OEt                                       4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    OEt                                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    OEt                                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    OEt                                       4-CF.sub.3                                                                            5-Br     H        O     Me    O-n-Bu                                    4-Cl   5-Br     H        O     Me    O-n-Bu                                    4-Br   5-Br     H        O     Me    O-n-Bu                                    4-OCF.sub.3                                                                           5-Br     H        O     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Cl     H        O     Me    O-n-Bu                                    4-Cl   5-Cl     H        O     Me    O-n-Bu                                    4-Br   5-Cl     H        O     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-n-Bu                                    4-CF.sub.3                                                                            4-F      H        O     Me    O-n-Bu                                    4-CF.sub.3                                                                            H        H        O     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-n-Bu                                    4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-n-Bu                                    4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Cl     H        S     Me    O-n-Bu                                    4-Cl   5-Cl     H        S     Me    O-n-Bu                                    4-Br   5-Cl     H        S     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Br     H        S     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-F      H        S     Me    O-n-Bu                                    4-CF.sub.3                                                                            4-Cl     H        S     Me    O-n-Bu                                    4-CF.sub.3                                                                            4-F      H        S     Me    O-n-Bu                                    4-CF.sub.3                                                                            H        H        S     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-n-Bu                                    4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-n-Bu                                    4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-n-Bu                                    4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-n-Bu                                    4-CF.sub.3                                                                            5-Br     H        O     Me    O-n-hexyl                                 4-Cl   5-Br     H        O     Me    O-n-hexyl                                 4-Br   5-Br     H        O     Me    O-n-hexyl                                 4-OCF.sub.3                                                                           5-Br     H        O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Cl     H        O     Me    O-n-hexyl                                 4-Cl   5-Cl     H        O     Me    O-n-hexyl                                 4-Br   5-Cl     H        O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            4-F      H        O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            H        H        O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Cl     H        S     Me    O-n-hexyl                                 4-Cl   5-Cl     H        S     Me    O-n-hexyl                                 4-Br   5-Cl     H        S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Br     H        S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-F      H        S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            4-Cl     H        S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            4-F      H        S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            H        H        S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-n-hexyl                                 4-CF.sub.3                                                                            5-Br     H        O     Me    O-n-octyl                                 4-Cl   5-Br     H        O     Me    O-n-octyl                                 4-Br   5-Br     H        O     Me    O-n-octyl                                 4-OCF.sub.3                                                                           5-Br     H        O     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Cl     H        O     Me    O-n-octyl                                 4-Cl   5-Cl     H        O     Me    O-n-octyl                                 4-Br   5-Cl     H        O     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-n-octyl                                 4-CF.sub.3                                                                            4-F      H        O     Me    O-n-octyl                                 4-CF.sub.3                                                                            H        H        O     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-n-octyl                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-n-octyl                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Cl     H        S     Me    O-n-octyl                                 4-Cl   5-Cl     H        S     Me    O-n-octyl                                 4-Br   5-Cl     H        S     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Br     H        S     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-F      H        S     Me    O-n-octyl                                 4-CF.sub.3                                                                            4-Cl     H        S     Me    O-n-octyl                                 4-CF.sub.3                                                                            4-F      H        S     Me    O-n-octyl                                 4-CF.sub.3                                                                            H        H        S     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-n-octyl                                 4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-n-octyl                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-n-octyl                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-n-octyl                                 4-CF.sub.3                                                                            5-Br     H        O     Me    O-n-decyl                                 4-Cl   5-Br     H        O     Me    O-n-decyl                                 4-Br   5-Br     H        O     Me    O-n-decyl                                 4-OCF.sub.3                                                                           5-Br     H        O     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Cl     H        O     Me    O-n-decyl                                 4-Cl   5-Cl     H        O     Me    O-n-decyl                                 4-Br   5-Cl     H        O     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-n-decyl                                 4-CF.sub.3                                                                            4-F      H        O     Me    O-n-decyl                                 4-CF.sub.3                                                                            H        H        O     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-n-decyl                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-n-decyl                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Cl     H        S     Me    O-n-decyl                                 4-Cl   5-Cl     H        S     Me    O-n-decyl                                 4-Br   5-Cl     H        S     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Br     H        S     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-F      H        S     Me    O-n-decyl                                 4-CF.sub.3                                                                            4-Cl     H        S     Me    O-n-decyl                                 4-CF.sub.3                                                                            4-F      H        S     Me    O-n-decyl                                 4-CF.sub.3                                                                            H        H        S     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-n-decyl                                 4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-n-decyl                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-n-decyl                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-n-decyl                                 4-CF.sub.3                                                                            5-Br     H        O     Me    O-n-dodecyl                               4-Cl   5-Br     H        O     Me    O-n-dodecyl                               4-Br   5-Br     H        O     Me    O-n-dodecyl                               4-OCF.sub.3                                                                           5-Br     H        O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Cl     H        O     Me    O-n-dodecyl                               4-Cl   5-Cl     H        O     Me    O-n-dodecyl                               4-Br   5-Cl     H        O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            4-F      H        O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            H        H        O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Cl     H        S     Me    O-n-dodecyl                               4-Cl   5-Cl     H        S     Me    O-n-dodecyl                               4-Br   5-Cl     H        S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Br     H        S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-F      H        S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            4-Cl     H        S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            4-F      H        S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            H        H        S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-n-dodecyl                               4-CF.sub.3                                                                            5-Br     H        O     Me    O-sec-Bu                                  4-Cl   5-Br     H        O     Me    O-sec-Bu                                  4-Br   5-Br     H        O     Me    O-sec-Bu                                  4-OCF.sub.3                                                                           5-Br     H        O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Cl     H        O     Me    O-sec-Bu                                  4-Cl   5-Cl     H        O     Me    O-sec-Bu                                  4-Br   5-Cl     H        O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            4-F      H        O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            H        H        O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Cl     H        S     Me    O-sec-Bu                                  4-Cl   5-Cl     H        S     Me    O-sec-Bu                                  4-Br   5-Cl     H        S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Br     H        S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-F      H        S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            4-Cl     H        S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            4-F      H        S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            H        H        S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-sec-Bu                                  4-CF.sub.3                                                                            5-Br     H        O     Me    O-iPr                                     4-Cl   5-Br     H        O     Me    O-iPr                                     4-Br   5-Br     H        O     Me    O-iPr                                     4-OCF.sub.3                                                                           5-Br     H        O     Me    O-iPr                                     4-CF.sub.3                                                                            5-Cl     H        O     Me    O-iPr                                     4-Cl   5-Cl     H        O     Me    O-iPr                                     4-Br   5-Cl     H        O     Me    O-iPr                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    O-iPr                                     4-CF.sub.3                                                                            4-F      H        O     Me    O-iPr                                     4-CF.sub.3                                                                            H        H        O     Me    O-iPr                                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    O-iPr                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    O-iPr                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    O-iPr                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    O-iPr                                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    O-iPr                                     4-CF.sub.3                                                                            5-Cl     H        S     Me    O-iPr                                     4-Cl   5-Cl     H        S     Me    O-iPr                                     4-Br   5-Cl     H        S     Me    O-iPr                                     4-CF.sub.3                                                                            5-Br     H        S     Me    O-iPr                                     4-CF.sub.3                                                                            5-F      H        S     Me    O-iPr                                     4-CF.sub.3                                                                            4-Cl     H        S     Me    O-iPr                                     4-CF.sub.3                                                                            4-F      H        S     Me    O-iPr                                     4-CF.sub.3                                                                            H        H        S     Me    O-iPr                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    O-iPr                                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    O-iPr                                     4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    O-iPr                                     4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    O-iPr                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    O-iPr                                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    O-iPr                                     4-CF.sub.3                                                                            5-Br     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-Cl   5-Br     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-Br   5-Br     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-OCF.sub.3                                                                           5-Br     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Cl     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-Cl   5-Cl     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-Br   5-Cl     H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            4-F      H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            H        H        O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    OCH.sub. 2 CH.sub.2 OEt                   4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Cl     H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-Cl   5-Cl     H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-Br   5-Cl     H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Br     H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-F      H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            4-Cl     H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            4-F      H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            H        H        S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CH.sub.2 OEt                    4-CF.sub.3                                                                            5-Br     H        O     Me    OCH.sub.2 CCl.sub.3                       4-Cl   5-Br     H        O     Me    OCH.sub.2 CCl.sub.3                       4-Br   5-Br     H        O     Me    OCH.sub.2 CCl.sub.3                       4-OCF.sub.3                                                                           5-Br     H        O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Cl     H        O     Me    OCH.sub.2 CCl.sub.3                       4-Cl   5-Cl     H        O     Me    OCH.sub.2 CCl.sub.3                       4-Br   5-Cl     H        O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            4-F      H        O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            H        H        O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Cl     H        S     Me    OCH.sub.2 CCl.sub.3                       4-Cl   5-Cl     H        S     Me    OCH.sub.2 CCl.sub.3                       4-Br   5-Cl     H        S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Br     H        S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-F      H        S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            4-Cl     H        S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            4-F      H        S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            H        H        S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CCl.sub.3                       4-CF.sub.3                                                                            5-Br     H        O     Me    OCH.sub.2 CF.sub.3                        4-Cl   5-Br     H        O     Me    OCH.sub.2 CF.sub.3                        4-Br   5-Br     H        O     Me    OCH.sub.2 CF.sub.3                        4-OCF.sub.3                                                                           5-Br     H        O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Cl     H        O     Me    OCH.sub.2 CF.sub.3                        4-Cl   5-Cl     H        O     Me    OCH.sub.2 CF.sub.3                        4-Br   5-Cl     H        O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            4-F      H        O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            H        H        O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Cl     H        S     Me    OCH.sub.2 CF.sub.3                        4-Cl   5-Cl     H        S     Me    OCH.sub.2 CF.sub.3                        4-Br   5-Cl     H        S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Br     H        S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-F      H        S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            4-Cl     H        S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            4-F      H        S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            H        H        S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CF.sub. 3                       4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CF.sub.3                        4-CF.sub.3                                                                            5-Br     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-Cl   5-Br     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-Br   5-Br     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-OCF.sub.3                                                                           5-Br     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Cl     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-Cl   5-Cl     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-Br   5-Cl     H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            4-F      H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            H        H        O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Cl     H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-Cl   5-Cl     H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-Br   5-Cl     H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Br     H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-F      H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            4-Cl     H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            4-F      H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            H        H        S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Br     H        O     Me    F                                         4-Cl   5-Br     H        O     Me    F                                         4-Br   5-Br     H        O     Me    F                                         4-OCF.sub.3                                                                           5-Br     H        O     Me    F                                         4-CF.sub.3                                                                            5-Cl     H        O     Me    F                                         4-Cl   5-Cl     H        O     Me    F                                         4-Br   5-Cl     H        O     Me    F                                         4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    F                                         4-CF.sub.3                                                                            4-F      H        O     Me    F                                         4-CF.sub.3                                                                            H        H        O     Me    F                                         4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    F                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    F                                         4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    F                                         4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    F                                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    F                                         4-CF.sub.3                                                                            5-Cl     H        S     Me    F                                         4-Cl   5-Cl     H        S     Me    F                                         4-Br   5-Cl     H        S     Me    F                                         4-CF.sub.3                                                                            5-Br     H        S     Me    F                                         4-CF.sub.3                                                                            5-F      H        S     Me    F                                         4-CF.sub.3                                                                            4-Cl     H        S     Me    F                                         4-CF.sub.3                                                                            4-F      H        S     Me    F                                         4-CF.sub.3                                                                            H        H        S     Me    F                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    F                                         4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    F                                         4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    F                                         4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    F                                         4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    F                                         4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    F                                         4-CF.sub.3                                                                            5-Br     H        O     Me    NMe.sub.2                                 4-Cl   5-Br     H        O     Me    NMe.sub.2                                 4-Br   5-Br     H        O     Me    NMe.sub.2                                 4-OCF.sub.3                                                                           5-Br     H        O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Cl     H        O     Me    NMe.sub.2                                 4-Cl   5-Cl     H        O     Me    NMe.sub.2                                 4-Br   5-Cl     H        O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            4-F      H        O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            H        H        O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Cl     H        S     Me    NMe.sub.2                                 4-Cl   5-Cl     H        S     Me    NMe.sub.2                                 4-Br   5-Cl     H        S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Br     H        S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-F      H        S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            4-Cl     H        S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            4-F      H        S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            H        H        S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Me    NMe.sub.2                                 4-CF.sub.3                                                                            5-Br     H        O     Et    O-iPr                                     4-Cl   5-Br     H        O     Et    O-iPr                                     4-Br   5-Br     H        O     Et    O-iPr                                     4-OCF.sub.3                                                                           5-Br     H        O     Et    O-iPr                                     4-CF.sub.3                                                                            5-Cl     H        O     Et    O-iPr                                     4-Cl   5-Cl     H        O     Et    O-iPr                                     4-Br   5-Cl     H        O     Et    O-iPr                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     Et    O-iPr                                     4-CF.sub.3                                                                            4-F      H        O     Et    O-iPr                                     4-CF.sub.3                                                                            H        H        O     Et    O-iPr                                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     Et    O-iPr                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     Et    O-iPr                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     Et    O-iPr                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     Et    O-iPr                                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     Et    O-iPr                                     4-CF.sub.3                                                                            5-Cl     H        S     Et    O-iPr                                     4-Cl   5-Cl     H        S     Et    O-iPr                                     4-Br   5-Cl     H        S     Et    O-iPr                                     4-CF.sub.3                                                                            5-Br     H        S     Et    O-iPr                                     4-CF.sub.3                                                                            5-F      H        S     Et    O-iPr                                     4-CF.sub.3                                                                            4-Cl     H        S     Et    O-iPr                                     4-CF.sub.3                                                                            4-F      H        S     Et    O-iPr                                     4-CF.sub.3                                                                            H        H        S     Et    O-iPr                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     Et    O-iPr                                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     Et    O-iPr                                     4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     Et    O-iPr                                     4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     Et    O-iPr                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     Et    O-iPr                                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     Et    O-iPr                                     4-CF.sub.3                                                                            5-Br     H        O     iPr   OEt                                       4-Cl   5-Br     H        O     iPr   OEt                                       4-Br   5-Br     H        O     iPr   OEt                                       4-OCF.sub.3                                                                           5-Br     H        O     iPr   OEt                                       4-CF.sub.3                                                                            5-Cl     H        O     iPr   OEt                                       4-Cl   5-Cl     H        O     iPr   OEt                                       4-Br   5-Cl     H        O     iPr   OEt                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     iPr   OEt                                       4-CF.sub.3                                                                            4-F      H        O     iPr   OEt                                       4-CF.sub.3                                                                            H        H        O     iPr   OEt                                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     iPr   OEt                                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     iPr   OEt                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     iPr   OEt                                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     iPr   OEt                                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     iPr   OEt                                       4-CF.sub.3                                                                            5-Cl     H        S     iPr   OEt                                       4-Cl   5-Cl     H        S     iPr   OEt                                       4-Br   5-Cl     H        S     iPr   OEt                                       4-CF.sub.3                                                                            5-Br     H        S     iPr   OEt                                       4-CF.sub.3                                                                            5-F      H        S     iPr   OEt                                       4-CF.sub.3                                                                            4-Cl     H        S     iPr   OEt                                       4-CF.sub.3                                                                            4-F      H        S     iPr   OEt                                       4-CF.sub.3                                                                            H        H        S     iPr   OEt                                       4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     iPr   OEt                                       4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     iPr   OEt                                       4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     iPr   OEt                                       4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     iPr   OEt                                       4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     iPr   OEt                                       4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     iPr   OEt                                       4-CF.sub.3                                                                            5-Br     H        O     iPr   O-nBu                                     4-Cl   5-Br     H        O     iPr   O-nBu                                     4-Br   5-Br     H        O     iPr   O-nBu                                     4-OCF.sub.3                                                                           5-Br     H        O     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Cl     H        O     iPr   O-nBu                                     4-Cl   5-Cl     H        O     iPr   O-nBu                                     4-Br   5-Cl     H        O     iPr   O-nBu                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     iPr   O-nBu                                     4-CF.sub.3                                                                            4-F      H        O     iPr   O-nBu                                     4-CF.sub.3                                                                            H        H        O     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     iPr   O-nBu                                     4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     iPr   O-nBu                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     iPr   O-nBu                                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Cl     H        S     iPr   O-nBu                                     4-Cl   5-Cl     H        S     iPr   O-nBu                                     4-Br   5-Cl     H        S     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Br     H        S     iPr   O-nBu                                     4-CF.sub.3                                                                            5-F      H        S     iPr   O-nBu                                     4-CF.sub.3                                                                            4-Cl     H        S     iPr   O-nBu                                     4-CF.sub.3                                                                            4-F      H        S     iPr   O-nBu                                     4-CF.sub.3                                                                            H        H        S     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             S     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             S     iPr   O-nBu                                     4-CF.sub.3                                                                            5-F      CO.sub.2 Me                                                                             S     iPr   O-nBu                                     4-CF.sub.3                                                                            4-Cl     CO.sub.2 Me                                                                             S     iPr   O-nBu                                     4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             S     iPr   O-nBu                                     4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             S     iPr   O-nBu                                     4-CF.sub.3                                                                            5-Br     H        O     iPr   OCH.sub.2 CF.sub.3                        4-Cl   5-Br     H        O     iPr   OCH.sub.2 CO.sub.2 Me                     4-Br   5-Br     H        O     iPr   NMe.sub.2                                 4-OCF.sub.3                                                                           5-Br     H        O     iPr   NEt.sub.2                                 4-CF.sub.3                                                                            5-Cl     H        O     iPr   piperidino                                4-Cl   5-Cl     H        O     iPr   Et                                        4-Br   5-Cl     H        O     iPr   4-BrPh                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                              H        O     CH.sub.2 Ph                                                                          OEt                                       4-CF.sub.3                                                                            4-F      H        O     CH.sub.2 Ph                                                                          O-n-octyl                                 4-CF.sub.3                                                                            H        H        O     CH.sub.2 Ph                                                                          OCH.sub.2 CO.sub.2 Et                     4-CF.sub.3                                                                            5-Br     CO.sub.2 Me                                                                             O     CH.sub.2 Ph                                                                          F                                         4-CF.sub.3                                                                            5-Cl     CO.sub.2 Me                                                                             O     CH.sub.2 Ph                                                                          NEt.sub.2                                 4-CF.sub.3                                                                            5-CF.sub.3                                                                              CO.sub.2 Me                                                                             O     CH.sub.2 Ph                                                                          morpholino                                4-CF.sub.3                                                                            4-F      CO.sub.2 Me                                                                             O     CH.sub.2 Ph                                                                          4-ClPh                                    4-CF.sub.3                                                                            H        CO.sub.2 Me                                                                             O     CH.sub.2 Ph                                                                          Et                                        4-CF.sub.3                                                                            5-Cl     H        S     CH.sub.2 Ph                                                                          Ph                                        ______________________________________                                    

                  TABLE 9                                                          ______________________________________                                          ##STR21##                                                                     R.sub.1                                                                               R.sub.2 B        V    R.sub.8                                                                             R.sub.9                                      ______________________________________                                         4-CF.sub.3                                                                            5-Br    H        O    Me   NMe.sub.2                                    4-Cl   5-Br    H        O    Me   NMe.sub.2                                    4-Br   5-Br    H        O    Me   NMe.sub.2                                    4-OCF.sub.3                                                                           5-Br    H        O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        O    Me   NMe.sub.2                                    4-Cl   5-Cl    H        O    Me   NMe.sub.2                                    4-Br   5-Cl    H        O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            4-F     H        O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            H       H        O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        S    Me   NMe.sub.2                                    4-Cl   5-Cl    H        S    Me   NMe.sub.2                                    4-Br   5-Cl    H        S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    H        S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-F     H        S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            4-Cl    H        S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            4-F     H        S    Me   NMe.sub.2                                    4-CF   H       H        S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    H        O    Me   NEt.sub.2                                    4-Cl   5-Br    H        O    Me   NEt.sub.2                                    4-Br   5-Br    H        O    Me   NEt.sub.2                                    4-OCF.sub.3                                                                           5-Br    H        O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        O    Me   NEt.sub.2                                    4-Cl   5-Cl    H        O    Me   NEt.sub.2                                    4-Br   5-Cl    H        O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            4-F     H        O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            H       H        O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        S    Me   NEt.sub.2                                    4-Cl   5-Cl    H        S    Me   NEt.sub.2                                    4-Br   5-Cl    H        S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Br    H        S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-F     H        S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            4-Cl    H        S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            4-F     H        S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            H       H        S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    Me   NEt.sub.2                                    4-CF.sub.3                                                                            5-Br    H        O    Me   piperidino                                   4-Cl   5-Br    H        O    Me   sec-Bu                                       4-Br   5-Br    H        O    Me   n-hexyl                                      4-OCF.sub.3                                                                           5-Br    H        O    Me   Ph                                           4-CF.sub.3                                                                            5-Cl    H        O    Me   4-ClPh                                       4-Cl   5-Cl    H        O    Me   4-MePh                                       4-Br   5-Cl    H        O    Me   n-Bu                                         4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    Et   NMe.sub.2                                    4-CF.sub.3                                                                            4-F     H        O    Et   NEt.sub.2                                    4-CF.sub.3                                                                            H       H        O    Et   morpholino                                   4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    Et   iPr                                          4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    Et   n-Bu                                         4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    Et   Ph                                           4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    Et   4-MeOPh                                      4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    Me   NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        S    Me   NEt.sub.2                                    4-Cl   5-Cl    H        S    Me   morpholino                                   4-Br   5-Cl    H        S    Me   iPr                                          4-CF.sub.3                                                                            5-Br    H        S    Me   n-Bu                                         4-CF.sub.3                                                                            5-F     H        S    Me   Ph                                           4-CF.sub.3                                                                            4-Cl    H        S    Me   4-MeOPh                                      4-CF.sub.3                                                                            4-F     H        S    Et   piperidino                                   4-CF.sub.3                                                                            H       H        S    Et   sec-Bu                                       4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    Et   n-hexyl                                      4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    Et   Ph                                           4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    Et   4-ClPh                                       4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    Et   4-MePh                                       4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    Et   n-Bu                                         4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    Et   2,6-di-Me-morpholino                         4-CF.sub.3                                                                            5-Br    H        O    iPr  NMe.sub.2                                    4-Cl   5-Br    H        O    iPr  NMe.sub.2                                    4-Br   5-Br    H        O    iPr  NMe.sub.2                                    4-OCF.sub.3                                                                           5-Br    H        O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        O    iPr  NMe.sub.2                                    4-Cl   5-Cl    H        O    iPr  NMe.sub.2                                    4-Br   5-Cl    H        O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            4-F     H        O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            H       H        O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    H        S    iPr  NMe.sub.2                                    4-Cl   5-Cl    H        S    iPr  NMe.sub.2                                    4-Br   5-Cl    H        S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    H        S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-F     H        S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            4-Cl    H        S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            4-F     H        S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            H       H        S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    iPr  NMe.sub.2                                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    iPr  NMe.sub.2                                    ______________________________________                                    

                                      TABLE 10                                     __________________________________________________________________________      ##STR22##                                                                     R.sub.1                                                                              R.sub.2                                                                             B     V  R.sub.8                                                                            Y' Y'R.sub.1O                                                                            Y'R.sub.11                                   __________________________________________________________________________     4-CF.sub.3                                                                           5-Br H     O  tBu S  OEt    OEt                                          4-Cl  5-Br H     O  tBu S  OEt    OEt                                          4-Br  5-Br H     O  tBu S  OEt    OEt                                          4-OCF.sub.3                                                                          5-Br H     O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     O  tBu S  OEt    OEt                                          4-Cl  5-Cl H     O  tBu S  OEt    OEt                                          4-Br  5-Cl H     O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           H    H     O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     S  tBu S  OEt    OEt                                          4-Cl  5-Cl H     S  tBu S  OEt    OEt                                          4-Br  5-Cl H     S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-F  H     S  tBu S  oBt    OEt                                          4-CF.sub.3                                                                           4-Cl H     S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           H    H     S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  tBu S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Br H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Br H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-OCF.sub.3                                                                          5-Br H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Cl H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Cl H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    H     O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Cl H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Cl H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-F  H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-Cl H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    H     S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-Cl  5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-Br  5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-OCF.sub.3                                                                          5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-Cl  5-Cl H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-Br  5-Cl H     O  tBu S   OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-F  H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           H    H     O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-Cl  5-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-Br  5-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Br H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-F  H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-F  H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           H    H     S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                       4-CF.sub.3                                                                           5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-Cl  5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-Br  5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-OCF.sub.3                                                                          5-Br H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Cl H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-Cl  5-Cl H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-Br  5-Cl H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           4-F  H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           H    H     O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-Cl  5-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-Br  5-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Br H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-F  H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           4-Cl H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           4-F  H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           H    H     S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-Br CO Me S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  tBu S  OCH.sub.2 CH.sub.2 O                                4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  tBu S  OCH.sub. 2 CH.sub.2 O                               4-CF.sub.3                                                                           5-Br H     O  iPr S  OEt    OEt                                          4-Cl  5-Br H     O  iPr S  OEt    OEt                                          4-Br  5-Br H     O  iPr S  OEt    OEt                                          4-OCF.sub.3                                                                          5-Br H     O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     O  iPr S  OEt    OEt                                          4-Cl  5-Cl H     O  iPr S  OEt    OEt                                          4-Br  5-Cl H     O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           H    H     O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl Co.sub.2 Me                                                                          O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     S  iPr S  OEt    OEt                                          4-Cl  5-Cl H     S  iPr S  OEt    OEt                                          4-Br  5-Cl H     S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-F  H     S  iPr S  OEt    OEt                                          4-CF.sub. 3                                                                          4-Cl H     S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           H    H     S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  iPr S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Br H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Br H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-OCF.sub.3                                                                          5-Br H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Cl H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Cl H     O  iPr S  OCH.sub. 2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    H     O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Cl H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Cl H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-F  H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-Cl H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    H     S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br H     O  Me  S  OEt    OEt                                          4-Cl  5-Br H     O  Me  S  OEt    OEt                                          4-Br  5-Br H     O  Me  S  OEt    OEt                                          4-OCF.sub.3                                                                          5-Br H     O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     O  Me  S  OEt    OEt                                          4-Cl  5-Cl H     O  Me  S  OEt    OEt                                          4-Br  5-Cl H     O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           H    H     O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     S  Me  S  OEt    OEt                                          4-Cl  5-Cl H     S  Me  S  OEt    OEt                                          4-Br  5-Cl H     S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-F  H     S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           4-Cl H     S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           H    H     S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  Me  S  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     O  tBu O  OEt    OEt                                          4-Cl  5-Br H     O  tBu O  OEt    OEt                                          4-Br  5-Br H     O  tBu O  OEt    OEt                                          4-OCF.sub.3                                                                          5-Br H     O  tBu O  oBt    OEt                                          4-CF.sub.3                                                                           5-Cl H     O  tBu O  OEt    OEt                                          4-Cl  5-Cl H     O  tBu O  OEt    OEt                                          4-Br  5-Cl H     O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     O  tBu O  OBt    OEt                                          4-CF.sub.3                                                                           H    H     O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl H     S  tBu O  OEt    OEt                                          4-Cl  5-Cl H     S  tBu O  OEt    OEt                                          4-Br  5-Cl H     S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-F  H     S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           4-Cl H     S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           4-F  H     S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           H    H     S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  tBu O  OEt    OEt                                          4-CF.sub.3                                                                           5-Br H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Br H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Br H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-OCF.sub.3                                                                          5-Br H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Cl H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Cl H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-CF.sub.3                                                                          H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    H     O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-CF.sub.3                                                                          CO.sub.2 Me                                                                          O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          O  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Cl  5-Cl H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-Br  5-Cl H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-F  H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-Cl H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    H     S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Cl CO.sub.2 Me                                                                          S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-Br CO.sub.2 Me                                                                          S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           5-F  CO.sub.2 Me                                                                          S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-Cl CO.sub.2 Me                                                                          S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           4-F  CO.sub.2 Me                                                                          S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    4-CF.sub.3                                                                           H    CO.sub.2 Me                                                                          S  tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                    __________________________________________________________________________

                  TABLE 11                                                         ______________________________________                                          ##STR23##                                                                     R.sub.1                                                                               R.sub.2 B        V    R.sub.8                                                                             Y'  R.sub.10                                                                             Y'R.sub.11                         ______________________________________                                         4-CF.sub.3                                                                            5-Br    H        O    iPr  O   Et    OEt                                4-Cl   5-Br    H        O    iPr  O   Et    OEt                                4-Br   5-Br    H        O    iPr  O   Et    OEt                                4-OCF.sub.3                                                                           5-Br    H        O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    H        O    iPr  O   Et    OEt                                4-Cl   5-Cl    H        O    iPr  O   Et    OEt                                4-Br   5-Cl    H        O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    iPr  O   Et    OEt                                4-CF.sub. 3                                                                           4-F     H        O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            H       H        O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            B-Br    CO.sub.2 Me                                                                             O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-CF    CO Me    O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    H        S    iPr  O   Et    OEt                                4-Cl   5-Cl    H        S    iPr  O   Et    OEt                                4-Br   5-Cl    H        S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-Br    H        S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-F     H        S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            4-Cl    H        S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            4-F     H        S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            H       H        S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            S-Br    CO.sub.2 Me                                                                             S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            H       CO.sub. 2 Me                                                                            S    iPr  O   Et    OEt                                4-CF.sub.3                                                                            5-Br    H        O    iPr  O   Et    O-iPr                              4-Cl   5-Br    H        O    iPr  O   Et    O-iPr                              4-Br   5-Br    H        O    iPr  O   Et    O-iPr                              4-OCF.sub.3                                                                           5-Br    H        O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Cl    H        O    iPr  O   Et    O-iPr                              4-Cl   5-Cl    H        O    iPr  O   Et    O-iPr                              4-Br   5-Cl    H        O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            4-F     H        O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            H       H        O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Cl    H        S    iPr  O   Et    O-iPr                              4-Cl   5-Cl    H        S    iPr  O   Et    O-iPr                              4-Br   5-Cl    H        S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Br    H        S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-F     H        S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            4-Cl    H        S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            4-F     H        S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            H       H        S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    iPr  O   Et    O-iPr                              4-CF.sub.3                                                                            5-Br    H        O    iPr  O   Et    OPh                                4-Cl   5-Br    H        O    iPr  O   Et    OPh                                4-Br   5-Br    H        O    iPr  O   Et    OPh                                4-OCF.sub.3                                                                           5-Br    H        O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Cl    H        O    iPr  O   Et    OPh                                4-Cl   5-Cl    H        O    iPr  O   Et    OPh                                4-Br   5-Cl    H        O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            4-F     H        O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            H       H        O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Cl    CO Me    O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Cl    H        S    iPr  O   Et    OPh                                4-Cl   5-Cl    H        S    iPr  O   Et    OPh                                4-Br   5-Cl    H        S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Br    H        S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-F     H        S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            4-Cl    H        S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            4-F     H        S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            H       H        S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    iPr  O   Et    OPh                                4-CF.sub.3                                                                            5-Br    H        O    iPr  O   Ph    OEt                                4-Cl   5-Br    H        O    iPr  O   Ph    OEt                                4-Br   5-Br    H        O    iPr  O   Ph    OEt                                4-OCF.sub.3                                                                           5-Br    H        O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Cl    H        O    iPr  O   Ph    OEt                                4-Cl   5-Cl    H        O    iPr  O   Ph    OEt                                4-Br   5-Cl    H        O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            4-F     H        O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            H       H        O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    iPr  O   Pb    OEt                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Cl    H        S    iPr  O   Ph    OEt                                4-Cl   5-Cl    H        S    iPr  O   Ph    OEt                                4-Br   5-Cl    H        S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Br    H        S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-F     H        S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            4-Cl    H        S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            4-F     H        S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            H       H        S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    iPr  O   Ph    OEt                                4-CF.sub. 3                                                                           5-F     CO.sub.2 Me                                                                             S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    iPr  O   Ph    OEt                                4-CF.sub.3                                                                            5-Br    H        O    tBu  O   Et    OEt                                4-Cl   5-Br    H        O    tBu  O   Et    OEt                                4-Br   5-Br    H        O    tBu  O   Et    OEt                                4-OCF.sub.3                                                                           5-Br    H        O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    H        O    tBu  O   Et    OEt                                4-Cl   5-Cl    H        O    tBu  O   Et    OEt                                4-Br   5-Cl    H        O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            4-F     H        O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            H       H        O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    H        S    tBu  O   Et    OEt                                4-Cl   5-Cl    H        S    tBu  O   Et    OEt                                4-Br   5-Cl    H        S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Br    H        S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-F     H        S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            4-Cl    H        S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            4-F     H        S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            H       H        S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    tBu  O   Et    OEt                                4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    tBu  O   Et    OEt                                4-Cl   5-Br    H        O    iPr  S   Et    O-iPr                              4-Br   5-Br    H        O    iPr  S   Et    OPh                                4-OCF.sub.3                                                                           5-Br    H        O    iPr  S   Ph    OEt                                4-CF.sub.3                                                                            5-Cl    H        O    iPr  S   Ph    O-iPr                              4-Cl   5-Cl    H        O    iPr  S   Ph    OPh                                4-Br   5-Cl    H        O    tBu  S   Et    OEt                                4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    tBu  S   Et    O-iPr                              4-CF.sub.3                                                                            4-F     H        O    tBu  S   Et    OPh                                4-CF.sub.3                                                                            H       H        O    tBu  S   Ph    OEt                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    tBu  S   Ph    O-iPr                              4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    tBu  S   Ph    OPh                                4-CF.sub.3                                                                            5-Br    H        S    iPr  S   iPr   OEt                                4-CF.sub.3                                                                            5-F     H        S    iPr  S   iPr   O-iPr                              4-CF.sub.3                                                                            4-Cl    H        S    iPr  S   iPr   OPh                                4-CF.sub.3                                                                            4-F     H        S    iPr  S   nPr   OEt                                4-CF.sub.3                                                                            H       H        S    iPr  S   nPr   O-iPr                              4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr  S   nPr   OPh                                4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    tBu  S   Me    OEt                                4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    tBu  S   Me    O-iPr                              4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    tBu  S   Me    OPh                                4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    tBu  S   Me    O-sec-Bu                           4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    tBu  S   Me    O-nPr                              ______________________________________                                    

                  TABLE 12                                                         ______________________________________                                          ##STR24##                                                                     R.sub.1   R.sub.2  B         V    R.sub.10                                                                             R.sub.11                               ______________________________________                                         4-CF.sub.3                                                                               5-Br     H         O    Et    Et                                     4-Cl      5-Br     H         O    Et    Et                                     4-Br      5-Br     H         O    Et    Et                                     4-OCF.sub.3                                                                              5-Br     H         O    Et    Et                                     4-CF.sub.3                                                                               5-Cl     H         O    Et    Et                                     4-Cl      5-Cl     H         O    Et    Et                                     4-Br      5-Cl     H         O    Et    Et                                     4-CF.sub.3                                                                               5-CF.sub.3                                                                              H         O    Et    Et                                     4-CF.sub.3                                                                               4-F      H         O    Et    Et                                     4-CF.sub.3                                                                               H        H         O    Et    Et                                     4-CF.sub.3                                                                               5-Br     CO.sub.2 Me                                                                              O    Et    Et                                     4-CF.sub.3                                                                               5-Cl     CO.sub.2 Me                                                                              O    Et    Et                                     4-CF.sub. 3                                                                              5-CF.sub.3                                                                              CO.sub.2 Me                                                                              O    Et    Et                                     4-CF.sub.3                                                                               4-F      CO.sub.2 Me                                                                              O    Et    Et                                     4-CF.sub.3                                                                               H        CO.sub.2 Me                                                                              O    Et    Et                                     4-CF.sub.3                                                                               5-Cl     H         S    Et    Et                                     4-Cl      5-Cl     H         S    Et    Et                                     4-Br      5-Cl     H         S    Et    Et                                     4-CF.sub.3                                                                               5-Br     H         S    Et    Et                                     4-CF.sub.3                                                                               5-F      H         S    Et    Et                                     4-CF.sub.3                                                                               4-Cl     H         S    Et    Et                                     4-CF.sub.3                                                                               4-F      H         S    Et    Et                                     4-CF.sub.3                                                                               H        H         S    Et    Et                                     4-CF.sub.3                                                                               5-Cl     CO.sub.2 Me                                                                              S    Et    Et                                     4-CF.sub.3                                                                               5-Br     CO.sub.2 Me                                                                              S    Et    Et                                     4-CF.sub.3                                                                               5-F      CO.sub.2 Me                                                                              S    Et    Et                                     4-CF.sub.3                                                                               4-Cl     CO.sub.2 Me                                                                              S    Et    Et                                     4-CF.sub.3                                                                               4-F      CO.sub.2 Me                                                                              S    Et    Et                                     4-CF.sub.3                                                                               H        CO.sub.2 Me                                                                              S    Et    Et                                     ______________________________________                                    

                  TABLE 13                                                         ______________________________________                                          ##STR25##                                                                     R.sub.1                                                                               R.sub.2 B        V    R.sub.8 R.sub.12                                  ______________________________________                                         4-CF.sub.3                                                                            5-Br    H        O    nBu     nBu                                       4-Cl   5-Br    H        O    nBu     nBu                                       4-Br   5-Br    H        O    nBu     nBu                                       4-OCF.sub.3                                                                           5-Br    H        O    nBu     nBu                                       4-CF.sub.3                                                                            5-Cl    H        O    nBu     nBu                                       4-Cl   5-Cl    H        O    nBu     nBu                                       4-Br   5-Cl    H        O    nBu     nBu                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    nBu     nBu                                       4-CF.sub.3                                                                            4-F     H        O    nBu     nBu                                       4-CF.sub.3                                                                            H       H        O    nBu     nBu                                       4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    nBu     nBu                                       4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    nBu     nBu                                       4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    nBu     nBu                                       4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    nBu     nBu                                       4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    nBu     nBu                                       4-CF.sub.3                                                                            5-Cl    H        S    nBu     nBu                                       4-Cl   5-Cl    H        S    nBu     nBu                                       4-Br   5-Cl    H        S    nBu     nBu                                       4-CF.sub.3                                                                            5-Br    H        S    nBu     nBu                                       4-CF.sub.3                                                                            5-F     H        S    nBu     nBu                                       4-CF.sub.3                                                                            4-Cl    H        S    nBu     nBu                                       4-CF.sub.3                                                                            4-F     H        S    nBu     nBu                                       4-CF.sub.3                                                                            H       H        S    nBu     nBu                                       4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    nBu     nBu                                       4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    nBu     nBu                                       4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    nBu     nBu                                       4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    nBu     nBu                                       4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    nBu     nBu                                       4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    nBu     nBu                                       4-CF.sub.3                                                                            5-Br    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                   4                                                 4-Cl   5-Br    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                   .                                                 4-Br   5-Br    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-OCF.sub.3                                                                           5-Br    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Cl    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-Cl   5-Cl    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-Br   5-Cl    H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            4-F     H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            H       H        O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Cl    H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-Cl   5-Cl    H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-Br   5-Cl    H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Br    H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-F     H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            4-Cl    H        S    CH.sub.2 CF.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            4-F     H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            H       H        S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub. 2 CH.sub.2 CH.sub.2                                           CH.sub.2                                          4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      4-CF.sub.3                                                                            5-Br    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-Cl   5-Br    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-Br   5-Br    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-OCF.sub.3                                                                           5-Br    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Cl    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-Cl   5-Cl    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-Br   5-Cl    H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            4-F     H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            H       H        O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Cl    H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-Cl   5-Cl    H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-Br   5-Cl    H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Br    H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-F     H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            4-Cl    H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            4-F     H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            H       H        S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2              4-CF.sub.3                                                                            5-Br    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-Cl   5-Br    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-Br   5-Br    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-OCF.sub.3                                                                           5-Br    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Cl    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-Cl   5-Cl    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-Br   5-Cl    H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            4-F     H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            H       H        O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Cl    H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-Cl   5-Cl    H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-Br   5-Cl    H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Br    H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-F     H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            4-Cl    H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            4-F     H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            H       H        S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    CH.sub.2 CHMeOCHMeCH.sub.2                        4-CF.sub.3                                                                            5-Br    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-Cl   5-Br    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-Br   5-Br    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-OCF.sub.3                                                                           5-Br    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Cl    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-Cl   5-Cl    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-Br   5-Cl    H        O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            4-F     H        O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            H       H        O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    Et      cyclo-C.sub.6 H.sub. 11                   4-CF.sub.3                                                                            5-Cl    H        S    Et      cyclo-C.sub.6 H.sub.11                    4-Cl   5-Cl    H        S    Et      cyclo-C.sub.6 H.sub.11                    4-Br   5-Cl    H        S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Br    H        S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-F     H        S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            4-Cl    H        S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            4-F     H        S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            H       H        S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    Et      cyclo-C.sub.6 H.sub.11                    4-CF.sub.3                                                                            5-Br    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-Cl   5-Br    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-Br   5-Br    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-OCF.sub.3                                                                           5-Br    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Cl    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-Cl   5-Cl    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-Br   5-Cl    H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-CF.sub.3                                                                             H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            4-F     H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            H       H        O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-CF.sub.3                                                                             CO.sub.2 Me                                                                             O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             O    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Cl    H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-Cl   5-Cl    H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-Br   5-Cl    H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Br    H        S    iPr     CH.sub.2 CH.sub. 2 CO.sub.2 Et            4-CF.sub.3                                                                            5-F     H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            4-Cl    H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            4-F     H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            H       H        S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Cl    CO.sub.2 Me                                                                             S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-Br    CO.sub.2 Me                                                                             S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            5-F     CO.sub.2 Me                                                                             S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            4-Cl    CO.sub.2 Me                                                                             S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            4-F     CO.sub.2 Me                                                                             S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             4-CF.sub.3                                                                            H       CO.sub.2 Me                                                                             S    iPr     CH.sub.2 CH.sub.2 CO.sub.2 Et             ______________________________________                                    

                  TABLE 14                                                         ______________________________________                                          ##STR26##                                                                     R.sub.1    R.sub.2   B          V     R.sub.10                                 ______________________________________                                         4-CF.sub.3 5-Br      H          O     tBu                                      4-Cl       5-Br      H          O     tBu                                      4-Br       5-Br      H          O     tBu                                      4-OCF.sub.3                                                                               5-Br      H          O     tBu                                      4-CF.sub.3 5-Cl      H          O     tBu                                      4-Cl       5-Cl      H          O     tBu                                      4-Br       5-Cl      H          O     tBu                                      4-CF.sub.3 5-CF.sub.3                                                                               H          O     tBu                                      4-CF.sub.3 4-F       H          O     tBu                                      4-CF.sub.3 H         H          O     tBu                                      4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               O     tBu                                      4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               O     tBu                                      4-CF.sub.3 5-CF.sub.3                                                                               CO.sub.2 Me                                                                               O     tBu                                      4-CF.sub.3 4-F       CO.sub.2 Me                                                                               O     tBu                                      4-CF.sub.3 H         CO.sub.2 Me                                                                               O     tBu                                      4-CF.sub.3 5-Cl      H          S     tBu                                      4-Cl       5-Cl      H          S     tBu                                      4-Br       5-Cl      H          S     tBu                                      4-CF.sub.3 5-Br      H          S     tBu                                      4-CF.sub.3 5-F       H          S     tBu                                      4-CF.sub.3 4-Cl      H          S     tBu                                      4-CF.sub.3 4-F       H          S     tBu                                      4-CF.sub.3 H         H          S     tBu                                      4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               S     tBu                                      4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               S     tBu                                      4-CF.sub.3 5-F       CO.sub.2 Me                                                                               S     tBu                                      4-CF.sub.3 4-Cl      CO.sub.2 Me                                                                               S     tBu                                      4-CF.sub.3 4-F       CO.sub.2 Me                                                                               S     tBu                                      4-CF.sub.3 H         CO.sub.2 Me                                                                               S     tBu                                      4-Br       5-Cl      H          S     sec-Bu                                   4-CF.sub.3 5-Br      H          S     sec-Bu                                   4-CF.sub.3 5-F       H          S     sec-Bu                                   4-CF.sub.3 4-Cl      H          S     sec-Bu                                   4-CF.sub.3 4-F       H          S     sec-Bu                                   4-CF.sub.3 H         H          S     sec-Bu                                   4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               S     sec-Bu                                   4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               S     sec-Bu                                   4-CF.sub.3 5-F       CO.sub.2 Me                                                                               S     sec-Bu                                   4-CF.sub.3 4-Cl      CO.sub.2 Me                                                                               S     sec-Bu                                   4-CF.sub.3 4-F       CO.sub.2 Me                                                                               S     sec-Bu                                   4-CF.sub.3 H         CO.sub.2 Me                                                                               S     sec-Bu                                   4-CF.sub.3 5-Br      H          O     Ph                                       4-Cl       5-Br      H          O     Ph                                       4-Br       5-Br      H          O     Ph                                       4-OCF.sub.3                                                                               5-Br      H          O     Ph                                       4-CF.sub.3 5-Cl      H          O     Ph                                       4-Cl       5-Cl      H          O     Ph                                       4-Br       5-Cl      H          O     Pb                                       4-CF.sub.3 5-CF.sub.3                                                                               H          O     Ph                                       4-CF.sub.3 4-F       H          O     Ph                                       4-CF.sub.3 H         H          O     Ph                                       4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               O     Ph                                       4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               O     Ph                                       4-CF.sub.3 5-CF.sub.3                                                                               CO.sub.2 Me                                                                               O     Ph                                       4-CF.sub.3 4-F       CO.sub.2 Me                                                                               O     Ph                                       4-CF.sub.3 H         CO.sub.2 Me                                                                               O     Ph                                       4-CF.sub.3 5-Cl      H          S     Ph                                       4-Cl       5-Cl      H          S     Ph                                       4-Br       5-Cl      H          S     Ph                                       4-CF.sub.3 5-Br      H          S     Ph                                       4-CF.sub.3 5-F       H          S     Ph                                       4-CF.sub.3 4-Cl      H          S     Ph                                       4-CF.sub.3 4-F       H          S     Ph                                       4-CF.sub.3 H         H          S     Ph                                       4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               S     Ph                                       4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               S     Ph                                       4-CF.sub.3 5-F       CO.sub.2 Me                                                                               S     Pb                                       4-CF.sub.3 4-Cl      CO.sub.2 Me                                                                               S     Ph                                       4-CF.sub.3 4-F       CO.sub.2 Me                                                                               S     Ph                                       4-CF.sub.3 H         CO.sub.2 Me                                                                               S     Ph                                       4-CF.sub.3 5-Br      H          O     4-ClPh                                   4-Cl       5-Br      H          O     4-ClPh                                   4-Br       5-Br      H          O     4-ClPh                                   4-OCF.sub.3                                                                               5-Br      H          O     4-ClPh                                   4-CF.sub.3 5-Cl      H          O     4-ClPh                                   4-Cl       5-Cl      H          O     4-ClPh                                   4-Br       5-Cl      H          O     4-ClPh                                   4-CF.sub.3 5-CF.sub.3                                                                               H          O     4-ClPh                                   4-CF.sub.3 4-F       H          O     4-ClPh                                   4-CF.sub.3 H         H          O     4-ClPh                                   4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               O     4-ClPh                                   4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               O     4-ClPh                                   4-CF.sub.3 5-CF.sub.3                                                                               CO.sub.2 Me                                                                               O     4-ClPh                                   4-CF.sub.3 4-F       CO.sub.2 Me                                                                               O     4-ClPh                                   4-CF.sub.3 H         CO.sub.2 Me                                                                               O     4-ClPh                                   4-CF.sub.3 5-Cl      H          S     4-ClPh                                   4-Cl       5-Cl      H          S     4-ClPh                                   4-Br       5-Cl      H          S     4-ClPh                                   4-CF.sub.3 5-Br      H          S     4-ClPh                                   4-CF.sub.3 5-F       H          S     4-ClPh                                   4-CF.sub.3 4-Cl      H          S     4-ClPh                                   4-CF.sub.3 4-F       H          S     4-ClPh                                   4-CF.sub.3 H         H          S     4-ClPh                                   4-CF.sub.3 5-Cl      CO.sub.2 Me                                                                               S     4-ClPh                                   4-CF.sub.3 5-Br      CO.sub.2 Me                                                                               S     4-ClPh                                   4-CF.sub.3 5-F       CO.sub.2 Me                                                                               S     4-ClPh                                   4-CF.sub.3 4-Cl      CO.sub.2 Me                                                                               S     4-ClPh                                   4-CF.sub.3 4-F       CO.sub.2 Me                                                                               S     4-ClPh                                   4-CF.sub.3 H         CO.sub.2 Me                                                                               S     4-ClPh                                   ______________________________________                                    

                  TABLE 15                                                         ______________________________________                                          ##STR27##                                                                     R.sub.1                                                                              R.sub.2 R.sub.13.sup.a                                                                          R.sub.13.sup.b                                                                       V   R.sub.8                                                                              R.sub.9                                 ______________________________________                                         4-CF.sub.3                                                                           5-F     Me       Me    S   Me    OEt                                     4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    OEt                                     4-CF.sub.3                                                                           4-F     Me       Me    S   Me    OEt                                     4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    OEt                                     4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Me    OEt                                     4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    OEt                                     4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    OEt                                     4-CF.sub.3                                                                           5-F     Me       Me    S   Me    O-nBu                                   4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    O-nBu                                   4-CF.sub.3                                                                           4-F     Me       Me    S   Me    O-nBu                                   4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    O-nBu                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Me    O-nBu                                   4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    O-nBu                                   4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    O-nBu                                   4-CF.sub.3                                                                           5-F     Me       Me    S   Me    O-nHexyl                                4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    O-nHexyl                                4-CF.sub.3                                                                           4-F     Me       Me    S   Me    O-nHexyl                                4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    O-nHexyl                                4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Me    O-nHexyl                                4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    O-nHexyl                                4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    O-nHexyl                                4-CF.sub.3                                                                           5-F     Me       Me    S   Me    O-sec-Bu                                4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    O-sec-Bu                                4-CF.sub.3                                                                           4-F     Me       Me    S   Me    O-sec-Bu                                4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    O-sec-Bu                                4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Me    O-sec-Bu                                4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    O-sec-Bu                                4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    O-sec-Bu                                4-CF.sub.3                                                                           5-F     Me       Me    S   Me    O-iPr                                   4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    O-iPr                                   4-CF.sub.3                                                                           4-F     Me       Me    S   Me    O-iPr                                   4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    O-iPr                                   4-CF.sub. 3                                                                          5-Br    CO.sub.2 Me                                                                             H     O   Me    O-iPr                                   4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    O-iPr                                   4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    O-iPr                                   4-CF.sub.3                                                                           5-F     Me       Me    S   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           4-F     Me       Me    S   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    OCH.sub.2 CH.sub.2 OEt                  4-CF.sub.3                                                                           5-F     Me       Me    S   Me    F                                       4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    F                                       4-CF.sub.3                                                                           4-F     Me       Me    S   Me    F                                       4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    F                                       4-CF.sub.3                                                                           S-Br    CO.sub.2 Me                                                                             H     O   Me    F                                       4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    F                                       4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    F                                       4-CF.sub.3                                                                           5-F     Me       Me    S   Me    NMe.sub.2                               4-CF.sub.3                                                                           5-Cl    Me       Me    S   Me    NMe.sub.2                               4-CF.sub.3                                                                           4-F     Me       Me    S   Me    NMe.sub.2                               4-CF.sub.3                                                                           5-Br    Ph       H     O   Me    NMe.sub.2                               4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Me    NMe.sub.2                               4-CF.sub.3                                                                           5-Br    Me       Me    O   Me    NMe.sub.2                               4-CF.sub.3                                                                           5-Cl    Me       Me    O   Me    NMe.sub.2                               4-CF.sub.3                                                                           5-F     Me       Me    S   Et    O-iPr                                   4-CF.sub.3                                                                           5-Cl    Me       Me    S   Et    O-iPr                                   4-CF.sub.3                                                                           4-F     Me       Me    S   Et    O-iPr                                   4-CF.sub.3                                                                           5-Br    Ph       H     O   Et    O-iPr                                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   Et    O-iPr                                   4-CF.sub.3                                                                           5-Br    Me       Me    O   Et    O-iPr                                   4-CF.sub.3                                                                           5-Cl    Me       Me    O   Et    O-iPr                                   4-CF.sub.3                                                                           5-F     Me       Me    S   iPr   OEt                                     4-CF.sub.3                                                                           5-Cl    Me       Me    S   iPr   OEt                                     4-CF.sub.3                                                                           4-F     Me       Me    S   ipr   OEt                                     4-CF.sub.3                                                                           5-Br    Ph       H     O   iPr   OEt                                     4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   iPr   OEt                                     4-CF.sub.3                                                                           5-Br    Me       Me    O   iPr   OEt                                     4-CF.sub.3                                                                           5-Cl    Me       Me    O   iPr   OEt                                     4-CF.sub.3                                                                           5-F     Me       Me    S   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           5-Cl    Me       Me    S   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           4-F     Me       Me    S   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           5-Br    Ph       H     O   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           5-Br    Me       Me    O   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           5-Cl    Me       Me    O   iPr   OCH.sub.2 CF.sub.3                      4-CF.sub.3                                                                           5-F     Me       Me    S   iPr   OCH.sub.2 CO.sub.2 Me                   4-CF.sub.3                                                                           5-Cl    Me       Me    S   iPr   OCH.sub.2 CO.sub.2 Me                   4-CF.sub.3                                                                           4-F     Me       Me    S   iPr   OCH.sub.2 CO.sub.2 Me                   4-CF.sub.3                                                                           5-Br    Ph       H     O   iPr   OCH.sub.2 CO.sub.2 Me                   4-CF.sub.3                                                                           5-Br    CO.sub.2 Me                                                                             H     O   iPr   OCH.sub.2 CO.sub.2 Me                   4-CF.sub.3                                                                           5-Br    Me       Me    O   iPr   OCH.sub.2 CO.sub.2 Me                   4-CF.sub.3                                                                           5-Cl    Me       Me    O   iPr   OCH.sub.2 CO.sub.2 Me                   ______________________________________                                    

                                      TABLE 16                                     __________________________________________________________________________      ##STR28##                                                                     R.sub.1  R.sub.2                                                                              R.sub.3 R.sub.8                                                                             R.sub.9                                            __________________________________________________________________________     4-CF.sub.3                                                                              4-Cl  H       Me   OEt                                                4-Cl     4-Cl  H       Me   OEt                                                4-Br     4-Cl  H       Me   OEt                                                4-OCF.sub.3                                                                             4-Cl  H       Me   OEt                                                4-OCF.sub.2 H                                                                           4-Cl  H       Me   OEt                                                3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  H       Me   OEt                                                4-CF.sub.3                                                                              4-F   H       Me   OEt                                                4-Cl     4-F   H       Me   OEt                                                4-Br     4-F   H       Me   OEt                                                4-OCF.sub.3                                                                             4-F   H       Me   OEt                                                4-OCF.sub.2 H                                                                           4-F   H       Me   OEt                                                3,4-CH.sub.2 C(Me).sub.2 O                                                              4-F   H       Me   OEt                                                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   OEt                                                4-Cl     4-OCF.sub.2 H                                                                        H       Me   OEt                                                4-Br     4-OCF.sub.2 H                                                                        H       Me   OEt                                                4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   OEt                                                4-OCF.sub.2 H                                                                           4-OCF.sub.2 H                                                                        H       Me   OEt                                                3,4-CH.sub.2 C(Me).sub.2 O                                                              4-OCF H                                                                              H       Me   OEt                                                4-CF.sub.3                                                                              4-Br  H       Me   OEt                                                4-CF.sub.3                                                                              4-Cl  4-Cl    Me   OEt                                                4-Cl     4-Cl  4-Cl    Me   OEt                                                4-Br     4-Cl  4-Cl    Me   OEt                                                4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   OEt                                                4-OCF.sub.2 H                                                                           4-Cl  4-Cl    Me   OEt                                                3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-Cl    Me   OEt                                                4-CF.sub.3                                                                              4-F   4-Cl    Me   OEt                                                4-OCF.sub.3                                                                             4-F   4-Cl    Me   OEt                                                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Me   OEt                                                4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Me   OEt                                                4-CF.sub.3                                                                              4-Cl  4-CN    Me   OEt                                                4-Cl     4-Cl  4-CN    Me   OEt                                                4-OCF.sub.3                                                                             4-Cl  4-CN    Me   OEt                                                4-CF.sub.3                                                                              4-F   4-CN    Me   OEt                                                4-OCF.sub.3                                                                             4-F   4-CN    Me   OEt                                                4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   OEt                                                4-CF.sub.3                                                                              4-Cl  H       Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  H       Me   O-n-Bu                                             4-CF.sub.3                                                                              4-F   H       Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-F   H       Me   O-n-Bu                                             3,4-CH.sub.2 C(Me).sub.2 O                                                              4-F   H       Me   O-n-Bu                                             4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   O-n-Bu                                             4-Cl     4-OCF.sub.2 H                                                                        H       Me   O-n-Bu                                             4-Br     4-OCF.sub.2 H                                                                        H       Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Br  H       Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  4-Cl    Me   O-n-Bu                                             4-Cl     4-Cl  4-Cl    Me   O-n-Bu                                             4-Br     4-Cl  4-Cl    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-F   4-Cl    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-F   4-Cl    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Me   O-n-Bu                                             4-Cl     4-OCF.sub.2 H                                                                        4-Cl    Me   O-n-Bu                                             4-Br     4-OCF.sub.2 H                                                                        4-Cl    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  4-CN    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  4-CN    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-F   4-CN    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-F   4-CN    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   O-n-Bu                                             4-CF.sub.3                                                                              4-OMe 4-Cl    Me   O-n-Bu                                             4-Cl     4-OPh 4-Cl    Me   O-n-Bu                                             4-Br     4-SCF.sub.2 H                                                                        4-Cl    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-NO.sub.2                                                                           4-Cl    Me   O-n-Bu                                             4-OCF.sub.2 H                                                                           4-SMe 4-Cl    Me   O-n-Bu                                             3,4-CH.sub.2 C(Me).sub.2 O                                                              4-SO.sub.2 Me                                                                        4-Cl    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-CN  4-Cl    Me   O-n-Bu                                             4-Cl     3-Cl  4-Cl    Me   O-n-Bu                                             4-Br     3-F   4-Cl    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-Me  4-Cl    Me   O-n-Bu                                             4-OCF.sub.2 H                                                                           4-allyl                                                                              4-Cl    Me   O-n-Bu                                             3,4-CH.sub.2 C(Me).sub.2 O                                                              4-CF.sub.3                                                                           4-Cl    Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Et                                                                          Me   O-n-Bu                                             4-Cl     4-Cl  4-OMe   Me   O-n-Bu                                             4-Br     4-Cl  4-SCF.sub.2 CF.sub.2 H                                                                 Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  4-OCF.sub.2 CF.sub.2 H                                                                 Me   O-n-Bu                                             4-OCF.sub.2 H                                                                           4-Cl  4-OPh   Me   O-n-Bu                                             3,4-CH.sub.2 C(Me).sub.2 O                                                              4-CF.sub.3                                                                           4-CF.sub.3                                                                             Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  4-CF.sub.3                                                                             Me   O-n-Bu                                             4-Cl     4-Cl  4-Me    Me   O-n-Bu                                             4-Br     4-Cl  3-Cl    Me   O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  3-Br    Me   O-n-Bu                                             4-OCF.sub.2 H                                                                           4-Cl  4-NO.sub.2                                                                             Me   O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  H       Me   O-n-hexyl                                          4-CF.sub.3                                                                              4-F   H       Me   O-n-hexyl                                          4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   O-n-hexyl                                          4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   O-n-octyl                                          4-CF.sub.3                                                                              4-Br  H       Me   O-n-octyl                                          4-CF.sub.3                                                                              4-Cl  4-Cl    Me   O-n-octyl                                          4-Cl     4-Cl  4-Cl    Me   O-n-octyl                                          4-Br     4-Cl  4-Cl    Me   O-n-octyl                                          4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   O-n-octyl                                          4-CF.sub.3                                                                              4-F   4-Cl    Me   O-n-decyl                                          4-Cl     4-F   4-Cl    Me   O-n-decyl                                          4-OCF.sub.3                                                                             4-F   4-Cl    Me   O-n-decyl                                          4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Me   O-n-decyl                                          4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Me   O-n-decyl                                          4-CF.sub.3                                                                              4-Cl  4-CN    Me   O-n-decyl                                          4-Cl     4-Cl  4-CN    Me   O-n-decyl                                          4-Br     4-Cl  4-CN    Me   O-n-decyl                                          4-OCF.sub.3                                                                             4-Cl  4-CN    Me   O-n-dodecyl                                        4-CF.sub.3                                                                              4-F   4-CN    Me   O-n-dodecyl                                        4-OCF.sub.3                                                                             4-F   4-CN    Me   O-n-dodecyl                                        4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   O-n-dodecyl                                        4-CF.sub. 3                                                                             4-Cl  H       Me   O-sec-Bu                                           4-Cl     4-Cl  H       Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-Cl  H       Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-F   H       Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-F   H       Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Br  H       Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Cl  4-Cl    Me   O-sec-Bu                                           4-Cl     4-Cl  4-Cl    Me   O-sec-Bu                                           4-Br     4-Cl  4-Cl    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-F   4-Cl    Me   O-sec-Bu                                           4-Cl     4-F   4-Cl    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-F   4-Cl    Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Cl  4-CN    Me   O-sec-Bu                                           4-Cl     4-Cl  4-CN    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-Cl  4-CN    Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-F   4-CN    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-F   4-CN    Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-CN  4-Cl    Me   O-sec-Bu                                           4-Cl     3-Cl  4-Cl    Me   O-sec-Bu                                           4-Br     3-F   4-Cl    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-Me  4-Cl    Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Et                                                                          Me   O-sec-Bu                                           4-Cl     4-Cl  4-OMe   Me   O-sec-Bu                                           4-Br     4-Cl  4-SCF.sub.2 CF.sub.2 H                                                                 Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-Cl  4-OCF.sub.2 CF.sub.2 H                                                                 Me   O-sec-Bu                                           4-OCF.sub.2                                                                             4-Cl  4-OPh   Me   O-sec-Bu                                           3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-CF.sub.3                                                                             Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Cl  4-CF.sub.3                                                                             Me   O-sec-Bu                                           4-Cl     4-Cl  4-Me    Me   O-sec-Bu                                           4-Br     4-Cl  3-Cl    Me   O-sec-Bu                                           4-OCF.sub.3                                                                             4-Cl  3-Br    Me   O-sec-Bu                                           4-OCF.sub.2 H                                                                           4-Cl  4-NO.sub.2                                                                             Me   O-sec-Bu                                           4-CF.sub.3                                                                              4-Cl  H       Me   O-iPr                                              4-OCF.sub.3                                                                             4-Cl  H       Me   O-iPr                                              4-CF.sub.3                                                                              4-F   H       Me   O-iPr                                              4-OCF.sub.3                                                                             4-F   H       Me   O-iPr                                              4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   O-iPr                                              4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   O-iPr                                              4-CF.sub.3                                                                              4-Br  H       Me   O-iPr                                              4-OCF.sub.3                                                                             4-Br  H       Me   O-iPr                                              4-CF.sub.3                                                                              4-Cl  4-Cl    Me   O-iPr                                              4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   O-iPr                                              4-CF.sub.3                                                                              4-F   4-Cl    Me   O-iPr                                              4-OCF.sub.3                                                                             4-F   4-Cl    Me   O-iPr                                              4-CF.sub.3                                                                              4-Cl  4-CN    Me   O-iPr                                              4-OCF.sub.3                                                                             4-Cl  4-CN    Me   O-iPr                                              4-CF.sub.3                                                                              4-F   4-CN    Me   O-iPr                                              4-OCF.sub.3                                                                             4-F   4-CN    Me   O-iPr                                              4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   O-iPr                                              4-CF.sub.3                                                                              4-Cl  H       Me   OCH.sub.2 CH.sub.2 OEt                             4-CF.sub.3                                                                              4-F   H       Me   OCH.sub.2 CH.sub.2 OEt                             4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   OCH.sub.2 CH.sub.2 OEt                             4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   OCH.sub.2 CCl.sub.3                                4-CF.sub.3                                                                              4-Br  H       Me   OCH.sub.2 CCl.sub.3                                4-CF.sub.3                                                                              4-Cl  4-Cl    Me   OCH.sub.2 CCl.sub.3                                4-Cl     4-Cl  4-Cl    Me   OCH.sub.2 CCl.sub.3                                4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   OCH.sub.2 CCl.sub.3                                4-CF.sub.3                                                                              4-F   4-Cl    Me   OCH.sub.2 CF.sub.3                                 4-OCF.sub.3                                                                             4-F   4-Cl    Me   OCH.sub.2 CF.sub.3                                 4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Me   OCH.sub.2 CF.sub.3                                 4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Me   OCH.sub.2 CF.sub.3                                 4-CF.sub.3                                                                              4-Cl  4-CN    Me   OCH.sub.2 CF.sub.3                                 4-OCF.sub.3                                                                             4-Cl  4-CN    Me   OCH.sub.2 CO.sub.2 Et                              4-CF.sub.3                                                                              4-F   4-CN    Me   OCH.sub.2 CO.sub.2 Et                              4-OCF.sub.3                                                                             4-F   4-CN    Me   OCH.sub.2 CO.sub.2 Et                              4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   OCH.sub.2 CO.sub.2 Et                              4-CF.sub.3                                                                              4-Cl  H       Me   F                                                  4-Cl     4-Cl  H       Me   F                                                  4-OCF.sub.3                                                                             4-Cl  H       Me   F                                                  4-CF.sub.3                                                                              4-F   H       Me   F                                                  4-OCF.sub.3                                                                             4-F   H       Me   F                                                  4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Me   F                                                  4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Me   NMe.sub.2                                          4-CF.sub.3                                                                              4-Br  H       Me   NMe.sub.2                                          4-CF.sub.3                                                                              4-Cl  4-Cl    Me   NMe.sub.2                                          4-Cl     4-Cl  4-Cl    Me   NMe.sub.2                                          4-OCF.sub.3                                                                             4-Cl  4-Cl    Me   NMe.sub.2                                          4-CF.sub.3                                                                              4-F   4-Cl    Me   NEt.sub.2                                          4-OCF.sub.3                                                                             4-F   4-Cl    Me   NEt.sub.2                                          4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Me   piperidino                                         4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Me   morpholino                                         4-CF.sub.3                                                                              4-Cl  4-CN    Me   n-Pr                                               4-OCF.sub.3                                                                             4-Cl  4-CN    Me   n-Pr                                               4-CF.sub.3                                                                              4-F   4-CN    Me   Sec-Bu                                             4-OCF.sub.3                                                                             4-F   4-CN    Me   4-ClPh                                             4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          Me   Ph                                                 4-CF.sub.3                                                                              4-Cl  H       Et   O-iPr                                              4-Cl     4-Cl  H       Et   O-iPr                                              4-OCF.sub.3                                                                             4-Cl  H       Et   O-iPr                                              4-CF.sub.3                                                                              4-F   H       Et   O-iPr                                              4-OCF.sub.3                                                                             4-F   H       Et   O-iPr                                              4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       Et   O-iPr                                              4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       Et   O-iPr                                              4-CF.sub.3                                                                              4-Br  H       Et   O-iPr                                              4-CF.sub.3                                                                              4-Cl  4-Cl    Et   O-iPr                                              4-OCF.sub.3                                                                             4-Cl  4-Cl    Et   O-iPr                                              4-CF.sub.3                                                                              4-F   4-Cl    Et   OEt                                                4-OCF.sub.3                                                                             4-F   4-Cl    Et   OEt                                                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    Et   OCH.sub.2 CCl.sub.3                                4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    Et   NEt.sub.2                                          4-CF.sub.3                                                                              4-Cl  4-CN    Et   2,6-di-Me-morpholino                               4-OCF.sub.3                                                                             4-Cl  4-CN    Et   2,6-di-Me-morpholino                               4-CF.sub.3                                                                              4-F   4-CN    Et   iPr                                                4-OCF.sub.3                                                                             4-F   4-CN    Et   Ph                                                 3,4-CH.sub.2 C(Me).sub.2 O                                                              4-F   4-CN    Et   Ph                                                 4-CF.sub.3                                                                              4-Cl  H       iPr  OEt                                                4-OCF.sub.3                                                                             4-Cl  H       iPr  OEt                                                4-CF.sub.3                                                                              4-F   H       iPr  OEt                                                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       iPr  OEt                                                4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       iPr  OEt                                                4-CF.sub.3                                                                              4-Br  H       iPr  OEt                                                4-CF.sub.3                                                                              4-Cl  4-Cl    iPr  OEt                                                4-Cl     4-Cl  4-Cl    iPr  OEt                                                4-Br     4-Cl  4-Cl    iPr  OEt                                                4-OCF.sub.3                                                                             4-Cl  4-Cl    iPr  OEt                                                4-CF.sub.3                                                                              4-F   4-Cl    iPr  OEt                                                4-OCF.sub.3                                                                             4-F   4-Cl    iPr  OEt                                                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    iPr  OEt                                                4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    iPr  OEt                                                4-CF.sub.3                                                                              4-Cl  4-CN    iPr  OEt                                                4-OCF.sub.3                                                                             4-Cl  4-CN    iPr  OEt                                                4-CF.sub.3                                                                              4-F   4-CN    iPr  OEt                                                4-OCF.sub.3                                                                             4-F   4-CN    iPr  OEt                                                4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          iPr  OEt                                                4-CF.sub.3                                                                              4-CN  4-Cl    iPr  OEt                                                4-Cl     3-Cl  4-Cl    iPr  OEt                                                4-Br     3-F   4-Cl    iPr  OEt                                                4-OCF.sub.3                                                                             4-Me  4-Cl    iPr  OEt                                                4-OCF.sub.2 H                                                                           4-o-allyl                                                                            4-Cl    iPr  OEt                                                3,4-CH.sub.2 C(Me).sub.2 O                                                              4-CF.sub.3                                                                           4-Cl    iPr  OEt                                                4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Et                                                                          iPr  OEt                                                4-Cl     4-Cl  4-OMe   iPr  OEt                                                4-Br     4-Cl  4-SCF.sub.2 CF.sub.2 H                                                                 iPr  OEt                                                4-OCF.sub.3                                                                             4-Cl  4-OCF.sub.2 CF.sub.2 H                                                                 iPr  OEt                                                4-OCF.sub.2 H                                                                           4-Cl  4-OPh   iPr  OEt                                                3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-CF.sub.3                                                                             iPr  OEt                                                4-CF.sub.3                                                                              4-Cl  4-CF.sub.3                                                                             iPr  OEt                                                4-Br     4-Cl  3-Cl    iPr  OEt                                                4-OCF.sub.3                                                                             4-Cl  3-Br    iPr  OEt                                                4-OCF.sub.2 H                                                                           4-Cl  4-NO.sub.2                                                                             iPr  OEt                                                4-CF.sub.3                                                                              4-Cl  H       iPr  O-n-Bu                                             4-Cl     4-Cl  H       iPr  O-n-Bu                                             4-Br     4-Cl  H       iPr  O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  H       iPr  O-n-Bu                                             4-CF.sub.3                                                                              4-F   H       iPr  O-n-Bu                                             4-OCF.sub.3                                                                             4-F   H       iPr  O-n-Bu                                             4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       iPr  O-n-Bu                                             4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H       iPr  O-n-Bu                                             4-CF.sub.3                                                                              4-Br  H       iPr  O-n-Bu                                             4-CF.sub.3                                                                              4-Cl  4-Cl    iPr  O-n-Bu                                             4-Br     4-Cl  4-Cl    iPr  O-n-Bu                                             4-OCF.sub.3                                                                             4-Cl  4-Cl    iPr  O-n-Bu                                             4-CF.sub.3                                                                              4-F   4-Cl    iPr  OCH.sub.2 CF.sub.3                                 4-OCF.sub.3                                                                             4-F   4-Cl    iPr  OCH.sub.2 CF.sub.3                                 4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl    iPr  OCH.sub.2 CO.sub.2 Me                              4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl    iPr  NMe.sub.2                                          4-CF.sub.3                                                                              4-Cl  4-CN    iPr  NEt.sub.2                                          4-OCF.sub.3                                                                             4-Cl  4-CN    iPr  NEt.sub.2                                          4-CF.sub.3                                                                              4-F   4-CN    iPr  piperidino                                         4-OCF.sub.3                                                                             4-F   4-CN    iPr  Et                                                 4-CF.sub.3                                                                              4-Cl  4-CO.sub.2 Me                                                                          iPr  Ph                                                 3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-CO.sub.2 Me                                                                          iPr  Ph                                                 4-CF.sub.3                                                                              4-Cl  H       CH.sub.2 Ph                                                                         OEt                                                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H       CH.sub.2 Ph                                                                         piperidino                                         4-CF.sub.3                                                                              4-Br  H       CH Ph                                                                               OCH.sub.2 CH.sub.2 OEt                             4-CF.sub.3                                                                              4-Cl  4-Cl    CH.sub.2 Ph                                                                         Me                                                 __________________________________________________________________________

                  TABLE 17                                                         ______________________________________                                          ##STR29##                                                                     R.sub.1    R.sub.2   R.sub.3   R.sub.8                                                                             R.sub.9                                    ______________________________________                                         4-CF.sub.3 4-Cl      H         Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-Cl      H         Me   NMe.sub.2                                  4-CF.sub.3 4-F       H         Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-F       H         Me   NMe.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            H         Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            H         Me   NMe.sub.2                                  4-CF.sub.3 4-Cl      4-Cl      Me   NMe.sub.2                                  4-Cl       4-Cl      4-Cl      Me   NMe.sub.2                                  4-Br       4-Cl      4-Cl      Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-Cl      4-Cl      Me   NMe.sub.2                                  4-CF.sub.3 4-F       4-Cl      Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-F       4-Cl      Me   NMe.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      Me   NMe.sub.2                                  4-OCF.sub. 3                                                                              4-OCF.sub.2 H                                                                            4-Cl      Me   NMe.sub.2                                  4-CF.sub.3 4-Cl      4-CN      Me   NMe.sub.2                                  4-Cl       4-Cl      4-CN      Me   NMe.sub.2                                  4-Br       4-Cl      4-CN      Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-Cl      4-CN      Me   NMe.sub.2                                  4-CF.sub.3 4-F       4-CN      Me   NMe.sub.2                                  4-OCF.sub.3                                                                               4-F       4-CN      Me   NMe.sub.2                                  4-CF.sub.3 4-Cl      4-CO.sub.2 Me                                                                            Me   NMe.sub.2                                  4-CF.sub.3 4-Cl      H         Me   NEt.sub.2                                  3,4-CH.sub.2 C(Me).sub.2 O                                                                4-Cl      H         Me   NEt.sub.2                                  4-CF.sub.3 4-F       H         Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-F       H         Me   NEt.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            H         Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            H         Me   NEt.sub.2                                  4-CF.sub.3 4-Br      H         Me   NEt.sub.2                                  3,4-CH.sub.2 C(Me).sub.2 O                                                                4-Br      H         Me   NEt.sub.2                                  4-CF.sub.3 4-Cl      4-Cl      Me   NEt.sub.2                                  4-Cl       4-Cl      4-Cl      Me   NEt.sub.2                                  4-Br       4-Cl      4-Cl      Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-Cl      4-Cl      Me   NEt.sub.2                                  4-CF.sub.3 4-F       4-Cl      Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-F       4-Cl      Me   NEt.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            4-Cl      Me   NEt.sub.2                                  4-OCF.sub.2 H                                                                             4-OCF.sub.2 H                                                                            4-Cl      Me   NEt.sub.2                                  3,4-CH.sub.2 C(Me).sub.2 O                                                                4-OCF.sub.2 H                                                                            4-Cl      Me   NEt.sub.2                                  4-CF.sub.3 4-Cl      4-CN      Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-Cl      4-CN      Me   NEt.sub.2                                  4-CF.sub.3 4-F       4-CN      Me   NEt.sub.2                                  4-OCF.sub.3                                                                               4-F       4-CN      Me   NEt.sub.2                                  4-CF.sub.3 4-Cl      4-CO.sub.2 Me                                                                            Me   NEt.sub.2                                  4-CF.sub.3 4-Cl      H         Me   piperidino                                 4-OCF.sub.3                                                                               4-Cl      H         Me   piperidino                                 4-CF.sub.3 4-F       H         Me   Sec-Bu                                     4-OCF.sub.3                                                                               4-F       H         Me   n-hexyl                                    4-CF.sub.3 4-OCF.sub.2 H                                                                            H         Me   Ph                                         4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            H         Me   Ph                                         4-CF.sub.3 4-Br      H         Me   4-ClPh                                     4-Cl       4-Br      H         Me   4-ClPh                                     4-CF.sub.3 4-Cl      4-Cl      Me   n-Bu                                       4-Cl       4-Cl      4-Cl      Me   n-Bu                                       4-Br       4-Cl      4-Cl      Me   n-Bu                                       4-OCF.sub.3                                                                               4-Cl      4-Cl      Me   n-Bu                                       4-CF.sub.3 4-F       4-Cl      Et   NMe.sub.2                                  4-OCF.sub.3                                                                               4-F       4-Cl      Et   NMe.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      Et   NEt.sub.2                                  4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            4-Cl      Et   morpholino                                 4-CF.sub.3 4-Cl      4-CN      Et   iPr                                        3,4-CH.sub.2 C(Me).sub.2 O                                                                4-Cl      4-CN      Et   n-Bu                                       4-CF.sub.3 4-F       4-CN      Et   n-Bu                                       4-CF.sub.3 4-Cl      4-CO.sub.2 Me                                                                            Et   4-MeOPh                                    4-CF.sub.3 4-Cl      H         iPr  NMe.sub.2                                  4-Cl       4-Cl      H         iPr  NMe.sub.2                                  4-Br       4-Cl      H         iPr  NMe.sub.2                                  4-OCF.sub.3                                                                               4-Cl      H         iPr  NMe.sub.2                                  4-CF.sub.3 4-F       H         iPr  NMe.sub.2                                  4-OCF.sub.3                                                                               4-F       H         iPr  NMe.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            H         iPr  NMe.sub.2                                  4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            H         iPr  NMe.sub.2                                  3,4-CH.sub.2 C(Me).sub.2 O                                                                4-OCF.sub.2 H                                                                            H         iPr  NMe.sub.2                                  4-CF.sub.3 4-Br      H         iPr  NMe.sub.2                                  4-CF.sub.3 4-Cl      4-Cl      iPr  NMe.sub.2                                  4-Cl       4-Cl      4-Cl      iPr  NMe.sub.2                                  4-Br       4-Cl      4-Cl      iPr  NMe.sub.2                                  4-OCF.sub.3                                                                               4-Cl      4-Cl      iPr  NMe.sub.2                                  4-CF.sub.3 4-F       4-Cl      iPr  NEt.sub.2                                  4-OCF.sub.3                                                                               4-F       4-Cl      iPr  NEt.sub.2                                  4-CF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      iPr  2,6-di-Me-                                                                     morpholino                                 4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                            4-Cl      iPr  piperidino                                 4-CF.sub.3 4-Cl      4-CN      iPr  Et                                         4-OCF.sub.3                                                                               4-Cl      4-CN      iPr  Et                                         4-CF.sub.3 4-F       4-CN      iPr  n-Bu                                       4-OCF.sub.3                                                                               4-F       4-CN      iPr  Ph                                         4-CF.sub.3 4-Cl      4-CO.sub.2 Me                                                                            iPr  4-ClPh                                     ______________________________________                                    

                  TABLE 18                                                         ______________________________________                                          ##STR30##                                                                     R.sub.1                                                                               R.sub.2  R.sub.3  R.sub.8                                                                             Y.sup.1                                                                             Y.sup.1 R.sub.10                                                                      Y.sup.1 R.sub.11                     ______________________________________                                         4-CF.sub.3                                                                            4-Cl     H        tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-Cl     H        tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      H        tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      H        tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H        tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           H        tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Br     H        tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-Cl     tBu  S    OEt    OEt                                  4-Cl   4-Cl     4-Cl     tBu  S    OEt    OEt                                  4-Br   4-Cl     4-Cl     tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-Cl     4-Cl     tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      4-Cl     tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      4-Cl     tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl     tBu  S    OEt    OEt                                  4-Br   4-OCF.sub.2 H                                                                           4-Cl     tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           4-Cl     tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-CN     tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-Cl     4-CN     tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      4-CN     tBu  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      4-CN     tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-CO.sub.2 Me                                                                           tBu  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-Cl     H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F      H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   4-F      H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F      H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub. 3                                                                           4-Br     H        tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   4-Cl     4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   4-Cl     4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-Cl     4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F      4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F      4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           4-Cl     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     4-CN     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-Cl     4-CN     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F      4-CN     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F      4-CN     tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     4-CO.sub.2 Me                                                                           tBu  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     H        iPr  S    OEt     OEt                                 4-Cl   4-Cl     H        iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-Cl     H        iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      H        iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      H        iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H        iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           H        iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Br     H        iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-Cl     iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-Cl     4-Cl     iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      4-Cl     iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      4-Cl     iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl     iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           4-Cl     iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-CN     iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-Cl     4-CN     iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      4-CN     iPr  S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      4-CN     iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-CO.sub.2 Me                                                                           iPr  S    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     H        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-Cl     H        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F      H        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub. 3                                                                          4-F      H        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Br     H        iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Cl   4-Cl     4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   4-Cl     4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-Cl     4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.2 H                                                                         4-Cl     4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-F      4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-Br   4-F      4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F      4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           4-Cl     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     4-CN     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-Cl     4-CN     iPr  S    OCHC(Me)CHO                                 4-CF.sub.3                                                                            4-F      4-CN     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-OCF.sub.3                                                                           4-F      4-CN     iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     4-CO.sub.2 Me                                                                           iPr  S    OCH.sub.2 C(Me).sub.2 CH.sub.2 O            4-CF.sub.3                                                                            4-Cl     H        tBu  S    OiPr   OiPr                                 4-CF.sub.3                                                                            4-F      H        tBu  S    OiPr   OiPr                                 4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H        tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           H        tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            4-Br     H        tBu  S    OCH.sub.2 CH.sub.2 CH.sub.2 O               4-CF.sub.3                                                                            4-Cl     4-Cl     tBu  S    OCH.sub.2 CH.sub.2 O                        4-Br   4-Cl     4-Cl     tBu  S    OCH.sub.2 CH.sub.2 O                        4-OCF.sub.3                                                                           4-Cl     4-Cl     tBu  S    OCH.sub.2 CH.sub.2 O                        4-CF.sub.3                                                                            4-F      4-Cl     Me   S    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      4-Cl     Me   S    OEt    OEt                                  4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl     Me   S    OEt    OEt                                  4-Cl   4-OCF.sub.2 H                                                                           4-Cl     Me   S    OEt    OEt                                  4-CF.sub.3                                                                            4-F      4-CN     tBu  O    OEt    OEt                                  4-OCF.sub.3                                                                           4-F      4-CN     tBu  O    OEt    OEt                                  4-CF.sub.3                                                                            4-Cl     4-CO.sub.2 Me                                                                           tBu  O    OCH.sub.2 C(Me).sub.2 CH.sub.2              ______________________________________                                                                            O                                      

                  TABLE 19                                                         ______________________________________                                          ##STR31##                                                                     R.sub.1    R.sub.2  R.sub.3  R.sub.8                                                                             Y.sup.1                                                                            R.sub.10                                                                            Y.sup.1 R.sub.11                    ______________________________________                                         4-CF.sub.3 4-Cl     H        iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-Cl     H        iPr  O   Et   OEt                                 4-CF.sub.3 4-F      H        iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-F      H        iPr  O   Et   OEt                                 4-CF.sub.3 4-OCF.sub.2 H                                                                           H        iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                           H        iPr  O   Et   OEt                                 4-CF.sub.3 4-Br     H        iPr  O   Et   OEt                                 4-CF.sub.3 4-Cl     4-Cl     iPr  O   Et   OEt                                 4-Cl       4-Cl     4-Cl     iPr  O   Et   OEt                                 4-Br       4-Cl     4-Cl     iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-Cl     4-Cl     iPr  O   Et   OEt                                 4-OCF.sub.2 H                                                                             4-Cl     4-Cl     iPr  O   Et   OEt                                 4-CF.sub.3 4-F      4-Cl     iPr  O   Et   OEt                                 4-Cl       4-F      4-Cl     iPr  O   Et   OEt                                 4-Br       4-F      4-Cl     iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-F      4-Cl     iPr  O   Et   OEt                                 4-CF.sub.3 4-OCF.sub.2 H                                                                           4-Cl     iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                           4-Cl     iPr  O   Et   OEt                                 4-CF.sub.3 4-Cl     4-CN     iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-Cl     4-CN     iPr  O   Et   OEt                                 4-CF.sub.3 4-F      4-CN     iPr  O   Et   OEt                                 4-OCF.sub.3                                                                               4-F      4-CN     iPr  O   Et   OEt                                 4-CF.sub.3 4-Cl     4-CO.sub.2 Me                                                                           iPr  O   Et   OEt                                 4-CF.sub.3 4-Cl     H        iPr  O   Et   OiPr                                4-OCF.sub.3                                                                               4-Cl     H        iPr  O   Et   OiPr                                4-CF.sub.3 4-F      H        iPr  O   Et   OiPr                                4-OCF.sub.3                                                                               4-F      H        iPr  O   Et   OiPr                                4-CF.sub.3 4-OCF.sub.2 H                                                                           H        iPr  O   Et   OiPr                                4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                           H        iPr  O   Et   OPh                                 4-OCF.sub.2 H                                                                             4-OCF.sub.2 H                                                                           H        iPr  O   Et   OPh                                 3,4-CH.sub.2 C(Me).sub.2 O                                                                4-OCF.sub.2 H                                                                           H        iPr  O   Et   OPh                                 4-CF.sub.3 4-Br     H        iPr  O   Et   OPh                                 4-CF.sub.3 4-Cl     4-Cl     iPr  O   Et   OPh                                 4-Cl       4-Cl     4-Cl     iPr  O   Et   OPh                                 4-Br       4-Cl     4-Cl     iPr  O   Et   OPh                                 4-OCF.sub.3                                                                               4-Cl     4-Cl     iPr  O   Et   OPh                                 4-OCF.sub.2 H                                                                             4-Cl     4-Cl     iPr  O   Et   OPh                                 4-CF.sub.3 4-F      4-CN     tBu  O   Et   OEt                                 4-OCF.sub.3                                                                               4-F      4-CN     tBu  O   Et   OEt                                 4-CF.sub.3 4-Cl     4-CO.sub.2 Me                                                                           tBu  O   Et   OEt                                 4-CF.sub.3 4-Cl     H        tBu  O   Et   OiPr                                4-OCF.sub.3                                                                               4-Cl     H        tBu  O   Et   OiPr                                4-CF.sub.3 4-F      H        tBu  O   Et   OiPr                                4-OCF.sub.3                                                                               4-F      H        tBu  O   Et   OiPr                                4-CF.sub.3 4-OCF.sub.2 H                                                                           H        tBu  O   Et   OiPr                                4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                           H        Ph   O   Et   OEt                                 4-CF.sub.3 4-F      H        iPr  S   Et   OEt                                 4-OCF.sub.3                                                                               4-F      H        iPr  S   Ph   OEt                                 4-CF.sub.3 4-OCF.sub.2 H                                                                           4-Cl     tBu  S   Et   OEt                                 4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                           4-Cl     tBu  S   Ph   OEt                                 4-CF.sub.3 4-F      4-CN     iPr  S   iPr  OiPr                                4-OCF.sub.3                                                                               4-F      4-CN     iPr  S   nPr  OEt                                 4-CF.sub.3 4-Cl     4-CO.sub.2 Me                                                                           tBu  S   Me   OEt                                 ______________________________________                                    

                  TABLE 20                                                         ______________________________________                                          ##STR32##                                                                     R.sub.1     R.sub.2   R.sub.3   R.sub.9                                        ______________________________________                                         4-CF.sub.3  4-Cl      H         CF.sub.3                                       4-CF.sub.3  4-F       H         CF.sub.3                                       4-CF.sub.3  4-OCF.sub.2 H                                                                            H         CF.sub.3                                       4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         CF.sub.3                                       4-CF.sub.3  4-Br      H         CF.sub.3                                       4-CF.sub.3  4-Cl      4-Cl      CF.sub.3                                       4-Cl        4-Cl      4-Cl      CF.sub.3                                       4-Br        4-Cl      4-Cl      CF.sub.3                                       4-OCF.sub.3 4-Cl      4-Cl      CF.sub.3                                       4-OCF.sub.2 H                                                                              4-Cl      4-Cl      CF.sub.3                                       3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-Cl      4-Cl      CF.sub.3                                       4-CF.sub.3  4-F       4-Cl      CF.sub.3                                       4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      CF.sub.3                                       4-CF.sub.3  4-Cl      4-CN      CF.sub.3                                       4-CF.sub.3  4-F       4-CN      CF.sub.3                                       4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            CF.sub.3                                       4-CF.sub.3  4-Cl      H         O-secBu                                        4-CF.sub.3  4-F       H         O-secBu                                        4-CF.sub.3  4-OCF.sub.2 H                                                                            H         O-secBu                                        4-Cl        4-OCF.sub.2 H                                                                            H         O-secBu                                        4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         O-secBu                                        4-CF.sub.3  4-Br      H         O-secBu                                        4-CF.sub.3  4-Cl      4-Cl      O-secBu                                        4-Cl        4-Cl      4-Cl      O-secBu                                        4-Br        4-Cl      4-Cl      O-secBu                                        4-OCF.sub.3 4-Cl      4-Cl      O-secBu                                        4-CF.sub.3  4-F       4-Cl      O-secBu                                        4-Cl        4-F       4-Cl      O-secBu                                        4-OCF.sub.3 4-F       4-Cl      O-secBu                                        4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      O-secBu                                        4-OCF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      O-secBu                                        4-CF.sub.3  4-Cl      4-CN      O-secBu                                        4-CF.sub.3  4-F       4-CN      O-secBu                                        4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            O-secBu                                        4-CF.sub.3  4-Cl      H         O-n-Bu                                         4-CF.sub.3  4-F       H         O-n-Bu                                         4-CF.sub.3  4-OCF.sub.2 H                                                                            H         O-n-Bu                                         4-Cl        4-OCF.sub.2 H                                                                            H         O-n-Bu                                         4-Br        4-OCF.sub.2 H                                                                            H         O-n-Bu                                         4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         O-n-Bu                                         4-OCF.sub.2 H                                                                              4-OCF.sub.2 H                                                                            H         O-n-Bu                                         3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-OCF.sub.2 H                                                                            H         O-n-Bu                                         4-CF.sub.3  4-Br      H         O-n-Bu                                         4-CF.sub.3  4-Cl      4-Cl      O-n-Bu                                         4-Cl        4-Cl      4-Cl      O-n-Bu                                         4-OCF.sub.3 4-Cl      4-Cl      O-n-Bu                                         4-CF.sub.3  4-F       4-Cl      O-n-hexyl                                      4-Cl        4-F       4-Cl      O-n-hexyl                                      4-OCF.sub.3 4-F       4-Cl      O-n-hexyl                                      4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      O-n-hexyl                                      4-CF.sub.3  4-Cl      4-CN      O-n-hexyl                                      4-CF.sub. 3 4-F       4-CN      O-n-hexyl                                      4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            O-n-hexyl                                      4-CF.sub.3  4-Cl      H         OCH.sub.2 CCl.sub.3                            4-CF.sub.3  4-F       H         OCH.sub.2 CCl.sub.3                            4-CF.sub.3  4-OCF.sub.2 H                                                                            H         OCH.sub.2 CCl.sub.3                            4-Cl        4-OCF.sub.2 H                                                                            H         OCH.sub.2 CCl.sub.3                            4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         OCH.sub.2 CCl.sub.3                            4-CF.sub.3  4-Br      H         OCH.sub.2 CCl.sub.3                            4-CF.sub.3  4-Cl      4-Cl      OCH.sub.2 CCl.sub.3                            4-Cl        4-Cl      4-Cl      OCH.sub.2 CCl.sub.3                            4-OCF.sub.3 4-Cl      4-Cl      OCH.sub.2 CCl.sub.3                            4-CF.sub.3  4-F       4-Cl      OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3  4-Cl      4-CN      OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3  4-F       4-CN      OCH.sub.2 CH.sub.2 OEt                         4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            OCH.sub.2 CH.sub.2 OEt                         ______________________________________                                    

                  TABLE 21                                                         ______________________________________                                          ##STR33##                                                                     R.sub.1    R.sub.2  R.sub.3   R.sub.10                                                                               R.sub.11                                 ______________________________________                                         4-CF.sub.3 4-Cl     H         Et      Et                                       4-CF.sub.3 4-F      H         Et      Et                                       4-CF.sub.3 4-OCF.sub.2 H                                                                           H         Et      Et                                       4-CF.sub.3 4-Br     H         Et      Et                                       4-CF.sub.3 4-Cl     4-Cl      Et      Et                                       4-Cl       4-Cl     4-Cl      Et      Et                                       4-Br       4-Cl     4-Cl      Et      Et                                       4-OCF.sub.3                                                                               4-Cl     4-Cl      Et      Et                                       4-OCF.sub.2 H                                                                             4-Cl     4-Cl      Et      Et                                       3,4-CH.sub.2 C(Me).sub.2 O                                                                4-Cl     4-Cl      Et      Et                                       4-CF.sub.3 4-F      4-Cl      Et      Et                                       4-Cl       4-F      4-Cl      Et      Et                                       4-Br       4-F      4-Cl      Et      Et                                       4-OCF.sub.3                                                                               4-F      4-Cl      Et      Et                                       4-OCF.sub.2 H                                                                             4-F      4-Cl      Et      Et                                       3,4-CH.sub.2 C(Me).sub.2 O                                                                4-F      4-Cl      Et      Et                                       4-CF.sub.3 4-OCF.sub.2 H                                                                           4-Cl      Et      Et                                       4-CF.sub.3 4-Cl     4-CN      Et      Et                                       4-CF.sub.3 4-F      4-CN      Et      Et                                       4-CF.sub.3 4-Cl     4-CO.sub.2 Me                                                                            Et      Et                                       4-CF.sub.3 4-Cl     H         CH.sub.2 CH.sub.2                                4-CF.sub.3 4-F      H         CH.sub.2 CH.sub.2                                4-CF.sub.3 4-OCF.sub.2 H                                                                           H         CH.sub.2 CH.sub.2                                4-CF.sub.3 4-Br     H         CH.sub.2 CH.sub.2                                4-CF.sub.3 4-Cl     4-Cl      CH.sub.2 CH.sub.2                                4-Cl       4-Cl     4-Cl      CH.sub.2 CH.sub.2                                4-OCF.sub.3                                                                               4-Cl     4-Cl      CH.sub.2 CH.sub.2                                4-CF.sub.3 4-F      4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                       4-Cl       4-F      4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                       4-OCF.sub.3                                                                               4-F      4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                       4-CF.sub.3 4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                       4-Cl       4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                       4-OCF.sub.3                                                                               4-OCF.sub.2 H                                                                           4-Cl      CH.sub.2 CH.sub.2 CH.sub.2                       4-CF.sub.3 4-Cl     4-CN      CH.sub.2 CH.sub.2 CH.sub.2                       4-CF.sub.3 4-F      4-CN      CH.sub.2 CH.sub.2 CH.sub.2                       4-CF.sub.3 4-Cl     4-CO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 CH.sub.2                       4-CF.sub.3 4-Cl     H         CH.sub.2 C(Me).sub.2 CH.sub.2                    4-CF.sub.3 4-F      H         CH.sub.2 C(Me).sub.2 CH.sub.2                    4-CF.sub.3 4-OCF.sub.2 H                                                                           H         CH.sub.2 C(Me).sub.2 CH.sub.2                    4-CF.sub.3 4-Br     H         CH.sub.2 C(Me).sub.2 CH.sub.2                    4-CF.sub.3 4-Cl     4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                    4-Cl       4-Cl     4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                    4-Br       4-Cl     4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                    4-OCF.sub.3                                                                               4-Cl     4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                    4-OCF.sub.2 H                                                                             4-Cl     4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                    3,4-CH.sub.2 C(Me).sub.2 O                                                                4-Cl     4-Cl      CH.sub.2 C(Me).sub.2 CH.sub.2                    4-CF.sub.3 4-F      4-Cl      Ph      Ph                                       4-CF.sub.3 4-OCF.sub.2 H                                                                           4-Cl      Ph      Ph                                       4-CF.sub.3 4-Cl     4-CN      Ph      Ph                                       4-CF.sub.3 4-F      4-CN      Ph      Ph                                       4-CF.sub.3 4-Cl     4-CO.sub.2 Me                                                                            Ph      Ph                                       ______________________________________                                    

                  TABLE 22                                                         ______________________________________                                          ##STR34##                                                                     R.sub.1  R.sub.2  R.sub.3  R.sub.8                                                                              R.sub.12                                      ______________________________________                                         4-CF.sub.3                                                                              4-Cl     H        nBu   nBu                                           4-Cl     4-Cl     H        nBu   nBu                                           4-OCF.sub.3                                                                             4-Cl     H        nBu   nBu                                           4-CF.sub.3                                                                              4-F      H        nBu   nBu                                           4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H        nBu   nBu                                           4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           H        nBu   nBu                                           4-CF.sub.3                                                                              4-Br     H        nBu   nBu                                           4-CF.sub.3                                                                              4-Cl     4-Cl     nBu   nBu                                           4-Cl     4-Cl     4-Cl     nBu   nBu                                           4-Br     4-Cl     4-Cl     nBu   nBu                                           4-OCF.sub.3                                                                             4-Cl     4-Cl     nBu   nBu                                           4-CF.sub.3                                                                              4-F      4-Cl     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2        4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2        4-CF.sub.3                                                                              4-Cl     4-CN     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2        4-CF.sub.3                                                                              4-F      4-CN     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2        4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                           CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2        4-CF.sub.3                                                                              4-Cl     H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-OCF.sub.3                                                                             4-Cl     H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-CF.sub.3                                                                              4-F      H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-OCF.sub.3                                                                             4-F      H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-CF.sub.3                                                                              4-Br     H        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-CF.sub.3                                                                              4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-Cl     4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-Br     4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                4-OCF.sub.3                                                                             4-Cl     4-Cl      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2               4-CF.sub.3                                                                              4-F      4-Cl     CH.sub.2 CHMeOCHMeCH.sub.2                          4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl     CH.sub.2 CHMeOCHMeCH.sub.2                          4-CF.sub.3                                                                              4-Cl     4-CN     CH.sub.2 CHMeOCHMeCH.sub.2                          4-CF.sub.3                                                                              4-F      4-CN     CH.sub.2 CHMeOCHMeCH.sub.2                          4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                           CH.sub.2 CHMeOCHMeCH.sub.2                          4-CF.sub.3                                                                              4-Cl     H        Et    cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                              4-F      H        Et    cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H        Et    cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                              4-Br     H        Et    cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                              4-Cl     4-Cl     Et    cyclo-C.sub.6 H.sub.11                        4-Cl     4-Cl     4-Cl     Et    cyclo-C.sub.6 H.sub.11                        4-Br     4-Cl     4-Cl     Et    cyclo-C.sub.6 H.sub.11                        4-OCF.sub.3                                                                             4-Cl     4-Cl     Et    cyclo-C.sub.6 H.sub.11                        4-CF.sub.3                                                                              4-F      4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-Cl     4-F      4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-OCF.sub.3                                                                             4-F      4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-Cl     4-OCF.sub.2 H                                                                           4-Cl     iPr    CH.sub.2 CH.sub.2 CO.sub.2 ET                4-Br     4-OCF.sub.2 H                                                                           4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-OCF.sub.2 H                                                                           4-OCF.sub.2 H                                                                           4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 3,4-     4-OCF.sub.2 H                                                                           4-Cl     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 CH.sub.2 C(Me).sub.2 O                                                         4-CF.sub.3                                                                              4-Cl     4-CN     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-Cl     4-Cl     4-CN     iPr   CH.sub.2 CH.sub.2 CO.sub.2 ET                 4-OCF.sub.3                                                                             4-Cl     4-CN     CF.sub.3                                                                             2,4-di-ClPh                                   4-CF.sub.3                                                                              4-F      4-CN     CF.sub.3                                                                             2,4-di-ClPh                                   4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                           CF.sub.3                                                                             2,4-di-ClPh                                   ______________________________________                                    

                  TABLE 23                                                         ______________________________________                                          ##STR35##                                                                     R.sub.1     R.sub.2   R.sub.3   R.sub.10                                       ______________________________________                                         4-CF.sub.3  4-Cl      H         tBu                                            4-OCF.sub.3 4-Cl      H         tBu                                            4-CF.sub.3  4-F       H         tBu                                            4-CF.sub.3  4-OCF.sub.2 H                                                                            H         tBu                                            4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         tBu                                            4-CF.sub.3  4-Br      H         tBu                                            4-CF.sub.3  4-Cl      4-Cl      tBu                                            4-Cl        4-Cl      4-Cl      tBu                                            4-Br        4-Cl      4-Cl      tBu                                            4-OCF.sub.3 4-Cl      4-Cl      tBu                                            4-OCF.sub.2 H                                                                              4-Cl      4-Cl      tBu                                            4-CF.sub.3  4-F       4-Cl      tBu                                            4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      tBu                                            4-Cl        4-OCF.sub.2 H                                                                            4-Cl      tBu                                            4-OCF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      tBu                                            4-CF.sub.3  4-Cl      4-CN      tBu                                            4-CF.sub.3  4-F       4-CN      tBu                                            4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            tBu                                            4-CF.sub.3  4-Cl      H         sec-Bu                                         4-OCF.sub.3 4-Cl      H         sec-Bu                                         4-CF.sub. 3 4-F       H         sec-Bu                                         4-OCF.sub.3 4-F       H         sec-Bu                                         4-CF.sub.3  4-OCF.sub.2 H                                                                            H         sec-Bu                                         4-Cl        4-OCF.sub.2 H                                                                            H         sec-Bu                                         4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         Ph                                             4-OCF.sub.2 H                                                                              4-OCF.sub.2 H                                                                            H         Ph                                             3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-OCF.sub.2 H                                                                            H         Ph                                             4-CF.sub.3  4-Br      H         Ph                                             4-CF.sub.3  4-Cl      4-Cl      Ph                                             4-Cl        4-Cl      4-Cl      Ph                                             4-Br        4-Cl      4-Cl      Ph                                             4-OCF.sub.3 4-Cl      4-Cl      Ph                                             4-OCF.sub.2 H                                                                              4-Cl      4-Cl      Ph                                             3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-Cl      4-Cl      Ph                                             4-CF.sub.3  4-F       4-Cl      4-ClPh                                         4-Cl        4-F       4-Cl      4-ClPh                                         4-Br        4-F       4-Cl      4-ClPh                                         4-OCF.sub.3 4-F       4-Cl      4-ClPh                                         4-OCF.sub.2 H                                                                              4-F       4-Cl      4-ClPh                                         3,4-CH.sub.2 C(Me).sub.2 O                                                                 4-F       4-Cl      4-ClPh                                         4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      4-ClPh                                         4-CF.sub.3  4-Cl      4-CN      4-ClPh                                         4-OCF.sub.3 4-Cl      4-CN      2-Me-4-t-BuPh                                  4-CF.sub.3  4-F       4-CN      2-Me-4-t-BuPh                                  4-OCF.sub.3 4-F       4-CN      2-Me-4-t-BuPh                                  4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            2-Me-4-t-BuPh                                  4-CF.sub.3  4-Cl      H         2-NO.sub.2Ph                                   4-OCF.sub.3 4-Cl      H         2-NO.sub.2Ph                                   4-CF.sub.3  4-F       H         2-NO.sub.2Ph                                   4-CF.sub.3  4-OCF.sub.2 H                                                                            H         2-NO.sub.2Ph                                   4-OCF.sub.3 4-OCF.sub.2 H                                                                            H         2-NO.sub.2 Ph                                  4-CF.sub.3  4-Br      H         2-NO.sub.2Ph                                   4-CF.sub.3  4-Cl      4-Cl      2-NO.sub.2Ph                                   4-Cl        4-Cl      4-Cl      2-NO.sub.2Ph                                   4-Br        4-Cl      4-Cl      2-NO.sub.2Ph                                   4-OCF.sub.3 4-Cl      4-Cl      2-NO.sub.2Ph                                   4-CF.sub.3  4-F       4-Cl      2-NO.sub.2 Ph                                  4-Cl        4-F       4-Cl      2-NO.sub.2 Ph                                  4-OCF.sub.3 4-F       4-Cl      2-NO.sub.2 Ph                                  4-CF.sub.3  4-OCF.sub.2 H                                                                            4-Cl      2-NO.sub.2 Ph                                  4-OCF.sub.3 4-OCF.sub.2 H                                                                            4-Cl      2-NO.sub.2 Ph                                  4-CF.sub.3  4-Cl      4-CN      2-NO.sub.2 Ph                                  4-OCF.sub.3 4-Cl      4-CN      2-NO.sub.2 Ph                                  4-CF.sub.3  4-F       4-CN      2-NO.sub.2 Ph                                  4-CF.sub.3  4-Cl      4-CO.sub.2 Me                                                                            2-NO.sub.2 Ph                                  ______________________________________                                    

                  TABLE 24                                                         ______________________________________                                          ##STR36##                                                                     R.sub.1    R.sub.2    R.sub.3  Z                                               ______________________________________                                         4-CF.sub.3 4-H        4-H      CH.sub.3                                        4-CF.sub.3 4-H        4-Cl     CH.sub.3                                        4-CF.sub.3 4-H        4-F      CH.sub.3                                        4-CF.sub.3 4-F        4-H      CH.sub.3                                        4-CF.sub.3 4-F        4-Cl     CH.sub.3                                        4-CF.sub.3 4-F        4-F      CH.sub.3                                        4-CF.sub.3 4-Cl       4-H      CH.sub.3                                        4-CF.sub.3 4-Cl       4-Cl     CH.sub.3                                        4-CF.sub.3 4-Cl       4-F      CH.sub.3                                        4-CF.sub.3 4-OCHF.sub.2                                                                              4-H      CH.sub.3                                        4-CF.sub.3 4-OCHF.sub.2                                                                              4-Cl     CH.sub.3                                        4-CF.sub.3 4-OCHF.sub.2                                                                              4-F      CH.sub.3                                        4-OCF.sub.3                                                                               4-H        4-H      CH.sub.3                                        4-OCF.sub.3                                                                               4-H        4-Cl     CH.sub.3                                        4-OCF.sub.3                                                                               4-H        4-F      CH.sub.3                                        4-OCF.sub.3                                                                               4-F        4-H      CH.sub.3                                        4-OCF.sub.3                                                                               4-F        4-Cl     CH.sub.3                                        4-OCF.sub.3                                                                               4-F        4-F      CH.sub.3                                        4-OCF.sub.3                                                                               4-Cl       4-H      CH.sub.3                                        4-OCF.sub.3                                                                               4-Cl       4-Cl     CH.sub.3                                        4-OCF.sub.3                                                                               4-Cl       4-F      CH.sub.3                                        4-Cl       4-H        4-H      CH.sub.3                                        4-Cl       4-H        4-Cl     CH.sub.3                                        4-Cl       4-H        4-F      CH.sub.3                                        4-Cl       4-Cl       4-H      CH.sub.3                                        4-Cl       4-Cl       4-Cl     CH.sub.3                                        4-Cl       4-Cl       4-F      CH.sub.3                                        4-Cl       4-F        4-H      CH.sub.3                                        4-Cl       4-F        4-Cl     CH.sub.3                                        4-Cl       4-F        4-F      CH.sub.3                                        4-Br       4-H        4-H      CH.sub.3                                        4-Br       4-H        4-F      CH.sub.3                                        4-Br       4-H        4-Cl     CH.sub.3                                        4-Br       4-Cl       4-H      CH.sub.3                                        4-Br       4-Cl       4-F      CH.sub.3                                        4-Br       4-Cl       4-Cl     CH.sub.3                                        4-Br       4-F        4-H      CH.sub.3                                        4-Br       4-F        4-F      CH.sub.3                                        4-Br       4-F        4-Cl     CH.sub.3                                        4-OCHF.sub.2                                                                              4-H        4-H      CH.sub.3                                        4-OCHF.sub.2                                                                              4-H        4-F      CH.sub.3                                        4-OCHF.sub.2                                                                              4-H        4-Cl     CH.sub.3                                        4-OCHF.sub.2                                                                              4-F        4-H      CH.sub.3                                        4-OCHF.sub.2                                                                              4-F        4-F      CH.sub.3                                        4-OCHF.sub.2                                                                              4-F        4-Cl     CH.sub.3                                        4-OCHF.sub.2                                                                              4-Cl       4-H      CH.sub.3                                        4-OCHF.sub.2                                                                              4-Cl       4-F      CH.sub.3                                        4-OCHF.sub.2                                                                              4-Cl       4-Cl     CH.sub.3                                        4-CF.sub.3 4-H        4-H      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-H        4-Cl     CH.sub.3 CH.sub.2                               4-CF.sub.3 4-H        4-F      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-F        4-H      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-F        4-Cl     CH.sub.3 CH.sub.2                               4-CF.sub.3 4-F        4-F      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-Cl       4-H      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 CH.sub.2                               4-CF.sub.3 4-Cl       4-F      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-OCHF.sub.2                                                                              4-H      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-OCHF.sub.2                                                                              4-Cl     CH.sub.3 CH.sub.2                               4-CF.sub.3 4-OCHF.sub.2                                                                              4-F      CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-H        4-H      CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-H        4-Cl     CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-H        4-F      CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-F        4-H      CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-F        4-Cl     CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-F        4-F      CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-Cl       4-H      CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-Cl       4-Cl     CH.sub.3 CH.sub.2                               4-OCF.sub.3                                                                               4-Cl       4-F      CH.sub.3 CH.sub.2                               4-Cl       4-H        4-H      CH.sub.3 CH.sub.2                               4-Cl       4-H        4-Cl     CH.sub.3 CH.sub.2                               4-Cl       4-H        4-F      CH.sub.3 CH.sub.2                               4-Cl       4-Cl       4-H      CH.sub.3 CH.sub.2                               4-Cl       4-Cl       4-Cl     CH.sub.3 CH.sub.2                               4-Cl       4-Cl       4-F      CH.sub.3 CH.sub.2                               4-Cl       4-F        4-H      CH.sub.3 CH.sub.2                               4-Cl       4-F        4-Cl     CH.sub.3 CH.sub.2                               4-Cl       4-F        4-F      CH.sub.3 CH.sub.2                               4-CF.sub.3 4-H        4-H      C.sub.6 H.sub.5                                 4-CF.sub.3 4-H        4-Cl     C.sub.6 H.sub.5                                 4-CF.sub.3 4-H        4-F      C.sub.6 H.sub.5                                 4-CF.sub.3 4-F        4-H      C.sub.6 H.sub.5                                 4-CF.sub.3 4-F        4-Cl     C.sub.6 H.sub.5                                 4-CF.sub.3 4-F        4-F      C.sub.6 H.sub.5                                 4-CF.sub.3 4-Cl       4-H      C.sub.6 H.sub.5                                 4-CF.sub.3 4-Cl       4-Cl     C.sub.6 H.sub.5                                 4-CF.sub.3 4-Cl       4-F      C.sub.6 H.sub.5                                 4-CF.sub.3 4-OCHF.sub.2                                                                              4-H      C.sub.6 H.sub.5                                 4-CF.sub.3 4-OCHF.sub.2                                                                              4-Cl     C.sub.6 H.sub.5                                 4-CF.sub.3 4-OCHF.sub.2                                                                              4-F      C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-H        4-H      C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-H        4-Cl     C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-H        4-F      C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-F        4-H      C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-F        4-Cl     C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-F        4-F      C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-Cl       4-H      C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-Cl       4-Cl     C.sub.6 H.sub.5                                 4-OCF.sub.3                                                                               4-Cl       4-F      C.sub.6 H.sub.5                                 4-Cl       4-H        4-H      C.sub.6 H.sub.5                                 4-Cl       4-H        4-Cl     C.sub.6 H.sub.5                                 4-Cl       4-H        4-F      C.sub.6 H.sub.5                                 4-Cl       4-F        4-H      C.sub.6 H.sub.5                                 4-Cl       4-F        4-Cl     C.sub.6 H.sub.5                                 4-Cl       4-F        4-F      C.sub.6 H.sub.5                                 4-CF.sub.3 4-H        4-H      CH.sub.3 O                                      4-CF.sub.3 4-H        4-Cl     CH.sub.3 O                                      4-CF.sub.3 4-H        4-F      CH.sub.3 O                                      4-CF.sub.3 4-F        4-H      CH.sub.3 O                                      4-CF.sub.3 4-F        4-Cl     CH.sub.3 O                                      4-CF.sub.3 4-F        4-F      CH.sub.3 O                                      4-CF.sub.3 4-Cl       4-H      CH.sub.3 O                                      4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 O                                      4-CF.sub.3 4-Cl       4-F      CH.sub.3 O                                      4-CF.sub.3 4-OCHF.sub.2                                                                              4-H      CH.sub.3 O                                      4-CF.sub.3 4-OCHF.sub.2                                                                              4-Cl     CH.sub.3 O                                      4-CF.sub.3 4-OCHF.sub.2                                                                              4-F      CH.sub.3 O                                      4-OCF.sub.3                                                                               4-H        4-H      CH.sub.3 O                                      4-OCF.sub.3                                                                               4-H        4-Cl     CH.sub.3 O                                      4-OCF.sub.3                                                                               4-H        4-F      CH.sub.3 O                                      4-OCF.sub.3                                                                               4-F        4-H      CH.sub.3 O                                      4-OCF.sub.3                                                                               4-F        4-Cl     CH.sub.3 O                                      4-OCF.sub.3                                                                               4-F        4-F      CH.sub.3 O                                      4-OCF.sub.3                                                                               4-Cl       4-H      CH.sub.3 O                                      4-OCF.sub.3                                                                               4-Cl       4-Cl     CH.sub.3 O                                      4-OCF.sub.3                                                                               4-Cl       4-F      CH.sub.3 O                                      4-Cl       4-H        4-H      CH.sub.3 O                                      4-Cl       4-H        4-Cl     CH.sub.3 O                                      4-Cl       4-H        4-F      CH.sub.3 O                                      4-Cl       4-Cl       4-H      CH.sub.3 O                                      4-Cl       4-Cl       4-Cl     CH.sub.3 O                                      4-Cl       4-Cl       4-F      CH.sub.3 O                                      4-Cl       4-F        4-H      CH.sub.3 O                                      4-Cl       4-F        4-Cl     CH.sub.3 O                                      4-Cl       4-F        4-F      CH.sub.3 O                                      4-CF.sub.3 4-H        4-H      H                                               4-CF.sub.3 4-H        4-Cl     H                                               4-CF.sub.3 4-H        4-F      H                                               4-CF.sub.3 4-F        4-H      H                                               4-CF.sub.3 4-F        4-Cl     H                                               4-CF.sub.3 4-F        4-F      H                                               4-CF.sub.3 4-Cl       4-H      H                                               4-CF.sub.3 4-Cl       4-Cl     H                                               4-CF.sub.3 4-Cl       4-F      H                                               4-CF.sub.3 4-OCHF.sub.2                                                                              4-H      H                                               4-CF.sub.3 4-OCHF.sub.2                                                                              4-Cl     H                                               4-CF.sub.3 4-OCHF.sub.2                                                                              4-F      H                                               4-OCF.sub.3                                                                               4-H        4-H      H                                               4-OCF.sub.3                                                                               4-H        4-Cl     H                                               4-OCF.sub.3                                                                               4-H        4-F      H                                               4-OCF.sub.3                                                                               4-F        4-H      H                                               4-OCF.sub.3                                                                               4-F        4-Cl     H                                               4-OCF.sub.3                                                                               4-F        4-F      H                                               4-OCF.sub.3                                                                               4-Cl       4-H      H                                               4-OCF.sub.3                                                                               4-Cl       4-Cl     H                                               4-OCF.sub.3                                                                               4-Cl       4-F      H                                               4-Cl       4-H        4-H      H                                               4-Cl       4-H        4-Cl     H                                               4-Cl       4-H        4-F      H                                               4-Cl       4-Cl       4-H      H                                               4-Cl       4-Cl       4-Cl     H                                               4-Cl       4-Cl       4-F      H                                               4-Cl       4-F        4-H      H                                               4-Cl       4-F        4-Cl     H                                               4-Cl       4-F        4-F      H                                               4-CF.sub.3 4-Cl       4-Cl     BrCH.sub.2                                      4-CF.sub.3 4-Cl       4-Cl     ClCH.sub.2                                      4-CF.sub.3 4-Cl       4-Cl     CF.sub.3                                        4-CF.sub.3 4-Cl       4-Cl     benzyl                                          4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 CH.sub.2 CH.sub.2                      4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.3                       4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.4                       4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.5                       4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.6                       4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.7                       4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.9                       4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.10                      4-CF.sub.3 4-Cl       4-Cl     Cl.sub.3 C                                      4-CF.sub.3 4-Cl       4-Cl     i-Pr                                            4-CF.sub.3 4-Cl       4-Cl     t-Bu                                            4-CF.sub.3 4-Cl       4-Cl     MeO.sub.2 C                                     4-CF.sub.3 4-Cl       4-Cl     EtO.sub.2 C                                     4-CF.sub.3 4-Cl       4-Cl     2-Cl-phenyl                                     4-CF.sub.3 4-Cl       4-Cl     3-Cl-phenyl                                     4-CF.sub.3 4-Cl       4-Cl     4-Cl-phenyl                                     4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 CH2O                                   4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.2 O                     4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.4 O                     4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.6 O                     4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.8 O                     4-CF.sub.3 4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.10 O                    4-CF.sub.3 4-Cl       4-Cl     phenyl-O                                        4-CF.sub.3 4-Cl       4-Cl     4-Cl-phenyl-O                                   4-CF.sub.3 4-Cl       4-Cl     benzyl-O                                        4-Cl       4-Cl       4-Cl     ClCH.sub.2                                      4-Cl       4-Cl       4-Cl     CF.sub.3                                        4-Cl       4-Cl       4-Cl     benzyl                                          4-Cl       4-Cl       4-Cl     CH.sub.3 (CH.sub.2).sub.3                       4-Cl       4-Cl       4-Cl     CH.sub.3 O.sub.2 C                              4-Cl       4-Cl       4-Cl     CH.sub.3 CH.sub.2 O                             ______________________________________                                    

                  TABLE 25                                                         ______________________________________                                          ##STR37##                                                                     R.sub.1  R.sub.2  R.sub.3    R.sub.8                                                                              R.sub.9                                     ______________________________________                                         4-CF.sub.3                                                                              4-Cl     H          Me    O-nBu                                       4-OCF.sub.3                                                                             4-Cl     H          Me    O-nBu                                       4-CF.sub.3                                                                              4-F      H          Me    O-nBu                                       4-OCF.sub.3                                                                             4-F      H          Me    O-nBu                                       4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H          Me    O-nBu                                       4-CF.sub.3                                                                              4-Br     H          Me    O-nBu                                       4-CF.sub.3                                                                              4-Cl     4-Cl       Me    O-nBu                                       4-Cl     4-Cl     4-Cl       Me    O-nBu                                       4-Br     4-Cl     4-Cl       Me    O-nBu                                       4-OCF.sub.3                                                                             4-Cl     4-Cl       Me    O-nBu                                       4-CF.sub.3                                                                              4-F      4-Cl       Me    O-nBu                                       4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl       Me    O-nBu                                       4-CF.sub.3                                                                              4-Cl     4-CN       Me    O-nBu                                       4-CF.sub.3                                                                              4-F      4-CN       Me    O-nBu                                       4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                             Me    O-nBu                                       4-CF.sub.3                                                                              4-Cl     H          Me    O-n-hexyl                                   4-CF.sub.3                                                                              4-F      H          Me    O-n-hexyl                                   4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H          Me    O-n-octyl                                   4-CF.sub.3                                                                              4-Br     H          Me    O-n-decyl                                   4-CF.sub.3                                                                              4-Cl     4-Cl       Me    O-n-dodecyl                                 4-Cl     4-Cl     4-Cl       Me    O-n-dodecyl                                 4-Br     4-Cl     4-Cl       Me    O-n-dodecyl                                 4-OCF.sub.3                                                                             4-Cl     4-Cl       Me    O-n-dodecyl                                 4-CF.sub.3                                                                              4-F      4-Cl       Me    O-sec-Bu                                    4-Cl     4-F      4-Cl       Me    O-sec-Bu                                    4-Br     4-F      4-Cl       Me    O-sec-Bu                                    4-OCF.sub.3                                                                             4-F      4-Cl       Me    O-sec-Bu                                    4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl       Me    O-sec-Bu                                    4-CF.sub.3                                                                              4-Cl     4-CN       Me    O-iPr                                       4-CF.sub.3                                                                              4-F      4-CN       Me    OCH.sub.2 CH.sub.2 OEt                      4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                             Me    OCH.sub.2 CF.sub.3                          4-CF.sub.3                                                                              4-Cl     H          Me    F                                           4-CF.sub.3                                                                              4-F      H          Me    NMe.sub.2                                   4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H          Me    NEt.sub.2                                   4-CF.sub.3                                                                              4-Br     H          Me    morpholino                                  4-OCF.sub.3                                                                             4-Br     H          Me    n-Pr                                        4-CF.sub.3                                                                              4-Cl     4-Cl       Me    sec-Bu                                      4-Br     4-Cl     4-Cl       Me    Ph                                          4-OCF.sub.3                                                                             4-Cl     4-Cl       Me    Ph                                          4-CF.sub.3                                                                              4-F      4-Cl       Et    O-iPr                                       4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl       Et    O-iPr                                       4-CF.sub.3                                                                              4-Cl     4-CN       Et    OCH.sub.2 CCl.sub.3                         4-OCF.sub.3                                                                             4-Cl     4-CN       Et    NEt.sub.2                                   4-CF.sub.3                                                                              4-F      4-CN       Et    2,6-di-Me-                                                                     morpholino                                  4-Cl     4-F      4-CN       Et    2,6-di-Me-                                                                     morpholino                                  4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                             Et    Ph                                          4-CF.sub.3                                                                              4-Cl     H          iPr   OEt                                         4-CF.sub.3                                                                              4-F      H          iPr   OEt                                         4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H          iPr   OEt                                         4-Cl     4-OCF.sub.2 H                                                                           H          iPr   OEt                                         4-Br     4-OCF.sub.2 H                                                                           H          iPr   OEt                                         4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           H          iPr   OEt                                         4-OCF.sub.2 H                                                                           4-OCF.sub.2 H                                                                           H          iPr   OEt                                         3,4-     4-OCF.sub.2 H                                                                           H          iPr   OEt                                         CH.sub.2 C(Me).sub.2 O                                                         4-CF.sub.3                                                                              4-Br     H          iPr   OEt                                         4-CF.sub.3                                                                              4-Cl     4-Cl       iPr   OEt                                         4-OCF.sub.3                                                                             4-Cl     4-Cl       iPr   OEt                                         4-CF.sub.3                                                                              4-F      4-Cl       iPr   OEt                                         4-OCF.sub.3                                                                             4-F      4-Cl       iPr   OEt                                         4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           4-Cl       iPr   OEt                                         4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           4-Cl       iPr   OEt                                         4-CF.sub.3                                                                              4-Cl     4-CN       iPr   OEt                                         4-OCF.sub.3                                                                             4-Cl     4-CN       iPr   OEt                                         4-CF.sub.3                                                                              4-F      4-CN       iPr   OEt                                         4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                             iPr   OEt                                         4-OCF.sub.3                                                                             4-Cl     4-CO.sub.2 Me                                                                             iPr   OEt                                         4-CF.sub.3                                                                              4-OMe    4-Cl       iPr   OEt                                         4-Cl     4-OPh    4-Cl       iPr   OEt                                         4-Br     4-SCF.sub.2 H                                                                           4-Cl       iPr   OEt                                         4-OCF.sub.3                                                                             4-NO.sub.2                                                                              4-Cl       iPr   OEt                                         4-OCF.sub.2 H                                                                           4-SMe    4-Cl       iPr   OEt                                         3,4-     4-SO.sub.2 Me                                                                           4-Cl       iPr   OEt                                         CH.sub.2 C(Me).sub.2 O                                                         4-CF.sub.3                                                                              4-CN     4-Cl       iPr   OEt                                         4-Cl     3-Cl     4-Cl       iPr   OEt                                         4-Br     3-F      4-Cl       iPr   OEt                                         4-OCF.sub.3                                                                             4-Me     4-Cl       iPr   OEt                                         4-OCF.sub.2 H                                                                           4-O-allyl                                                                               4-Cl       iPr   OEt                                         3,4-     4-CF.sub.3                                                                              4-Cl       iPr   OEt                                         CH.sub.2 C(Me).sub.2 O                                                         4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Et                                                                             iPr   OEt                                         4-Cl     4-Cl     4-OMe      iPr   OEt                                         4-Br     4-Cl     4-SCF.sub.2 CF.sub.2 H                                                                    iPr   OEt                                         4-OCF.sub.3                                                                             4-Cl     4-OCF.sub.2 CF.sub.2 H                                                                    iPr   OEt                                         4-CF.sub.3                                                                              4-Cl     4-CF.sub.3 iPr   OEt                                         4-Cl     4-Cl     4-Me       iPr   OEt                                         4-Br     4-Cl     3-Cl       iPr   OEt                                         4-OCF.sub.3                                                                             4-Cl     3-Br       iPr   OEt                                         4-OCF.sub.2 H                                                                           4-Cl     4-NO.sub.2 iPr   OEt                                         4-CF.sub.3                                                                              4-Cl     H          iPr   O-n-Bu                                      4-CF.sub.3                                                                              4-F      H          iPr   O-n-Bu                                      4-OCF.sub.3                                                                             4-F      H          iPr   OCH.sub.2 CO.sub.2 Me                       4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                           H          iPr   NMe.sub.2                                   4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                           H          iPr   piperidino                                  3,4-     4-OCF.sub.2 H                                                                           H          iPr   Et                                          CH.sub.2 C(Me).sub.2 O                                                         4-CF.sub.3                                                                              4-Br     H          iPr   Et                                          4-OCF.sub.3                                                                             4-Br     H          CH.sub.2 Ph                                                                          OEt                                         4-CF.sub.3                                                                              4-Cl     4-CO.sub.2 Me                                                                             CH.sub.2 Ph                                                                          NMe.sub.2                                   ______________________________________                                    

                  TABLE 26                                                         ______________________________________                                          ##STR38##                                                                     R.sub.1  R.sub.2    R.sub.3  R.sub.8                                                                               R.sub.9                                    ______________________________________                                         4-CF.sub.3                                                                              4-Cl       H        Me     NMe.sub.2                                  4-CF.sub.3                                                                              4-F        H        Me     NEt.sub.2                                  4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                             H        Me     n-hexyl                                    4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                             H        Me     Ph                                         4-CF.sub.3                                                                              4-Br       H        Me     4-MePh                                     4-CF.sub.3                                                                              4-Cl       4-Cl     Et     morpholino                                 4-Cl     4-Cl       4-Cl     Et     iPr                                        4-Br     4-Cl       4-Cl     Et     n-Bu                                       4-OCF.sub.3                                                                             4-Cl       4-Cl     Et     Ph                                         4-CF.sub.3                                                                              4-F        4-Cl     iPr    NMe.sub.2                                  4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                             4-Cl     iPr    piperidino                                 4-Cl     4-OCF.sub.2 H                                                                             4-Cl     iPr    Et                                         4-Br     4-OCF.sub.2 H                                                                             4-Cl     iPr    n-Bu                                       4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                             4-Cl     iPr    Ph                                         4-OCF.sub.2 H                                                                           4-OCF.sub.2 H                                                                             4-Cl     iPr    4-ClPh                                     ______________________________________                                    

                                      TABLE 27                                     __________________________________________________________________________      ##STR39##                                                                     R.sub.1  R.sub.2                                                                              R.sub.3                                                                              R.sub.8                                                                            Y.sup.1                                                                           Y.sup.1 R.sub.10                                                                     Y.sup.1 R.sub.11                             __________________________________________________________________________     4-CF.sub.3                                                                              4-Cl  H     tBu S  OEt   OEt                                          4-Cl     4-Cl  H     tBu S  OEt   OEt                                          4-Br     4-Cl  H     tBu S  OEt   OEt                                          4-OCF.sub.3                                                                             4-Cl  H     tBu S  OEt   OEt                                          4-OCF.sub.2 H                                                                           4-Cl  H     tBu S  OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  H     tBu S  OEt   OEt                                          4-CF.sub.3                                                                              4-F   H     tBu S  OEt   OEt                                          4-Cl     4-F   H     tBu S  OEt   OEt                                          4-Br     4-F   H     tBu S  OEt   OEt                                          4-OCF    4-F   H     tBu  S OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.2 H                                                                           4-F   H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                              4-F   H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Cl     4-OCF.sub.2 H                                                                        H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Br     4-OCF.sub.2 H                                                                        H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.2 H                                                                           4-OCF.sub.2 H                                                                        H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                              4-OCF.sub.2 H                                                                        H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                              4-Br  H     tBu S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Cl     4-Br  H     iPr S  OEt   OEt                                          4-Br     4-Br  H     iPr S  OEt   OEt                                          4-OCF.sub.3                                                                             4-Br  H     iPr S  OEt   OEt                                          4-OCF.sub.2 H                                                                           4-Br  H     iPr S  OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Br  H     iPr S  OEt   OEt                                          4-CF.sub.3                                                                              4-Cl  4-Cl  iPr S  OEt   OEt                                          4-Cl     4-Cl  4-Cl  iPr S  OEt   OEt                                          4-Br     4-Cl  4-Cl  iPr S  OEt   OEt                                          4-OCF.sub.3                                                                             4-Cl  4-Cl  iPr S  OEt   OEt                                          4-OCF.sub.2 H                                                                           4-Cl  4-Cl  iPr S  OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-Cl  iPr S  OEt   OEt                                          4-CF.sub.3                                                                              4-F   4-Cl  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Cl     4-F   4-Cl  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-Br     4-F   4-Cl  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.3                                                                             4-F   4-Cl  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-OCF.sub.2 H                                                                           4-F   4-Cl  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                              4-F   4-Cl  iPr S  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   4-CF.sub.3                                                                              4-OCF.sub.2 H                                                                        4-Cl  tBu S  OiPr  OiPr                                         4-Cl     4-OCF.sub.2 H                                                                        4-Cl  tBu S  OiPr  OiPr                                         4-Br     4-OCF.sub.2 H                                                                        4-Cl  tBu S  OiPr  OiPr                                         4-OCF.sub.3                                                                             4-OCF.sub.2 H                                                                        4-Cl  tBu S  OiPr  OiPr                                         4-OCF.sub.2 H                                                                           4-OCF.sub.2 H                                                                        4-Cl  tBu S  OiPr  OiPr                                         3,4-CH.sub.2 C(Me).sub.2 O                                                              4-OCF.sub.2 H                                                                        4-Cl  tBu S  OiPr  OiPr                                         4-CF.sub. 3                                                                             4-Cl  4-CN  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-Cl     4-Cl  4-CN  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-Br     4-Cl  4-CN  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-OCF.sub.3                                                                             4-Cl  4-CN  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                      4-OCF.sub.2 H                                                                           4-Cl  4-CN  tBu S  OCH.sub.2 CH.sub.2 CH.sub.2 O                      3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-CN  tBu S  OCH.sub.2 CH.sub.2 O                               4-CF.sub.3                                                                              4-F   4-CN  tBu S  OCH.sub.2 CH.sub.2 O                               4-Cl     4-F   4-CN  tBu S  OCH.sub.2 CH.sub.2 O                               4-Br     4-F   4-CN  tBu S  OCH.sub.2 CH.sub.2 O                               4-OCF.sub.3                                                                             4-F   4-CN  Me  S  OEt   OEt                                          4-OCF.sub.2 H                                                                           4-F   4-CN  Me  S  OEt   OEt                                          3,4-CH.sub.2 C(Me).sub.2 O                                                              4-F   4-CN  Me  S  OEt   OEt                                          4-Br     4-Cl  4-CO.sub.2 Me                                                                        tBu O  OEt   OEt                                          4-OCF.sub.3                                                                             4-Cl  4-CO.sub.2 Me                                                                        tBu O  OEt   OEt                                          4-OCF.sub.2 H                                                                           4-Cl  4-CO.sub.2 Me                                                                        tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   3,4-CH.sub.2 C(Me).sub.2 O                                                              4-Cl  4-CO.sub.2 Me                                                                        tBu O  OCH.sub.2 C(Me).sub.2 CH.sub.2 O                   __________________________________________________________________________

                  TABLE 28                                                         ______________________________________                                          ##STR40##                                                                     R.sub.1 R.sub.2   R.sub.3 R.sub.8                                                                             Y.sup.1                                                                             R.sub.10                                                                             Y.sup.1 R.sub.11                     ______________________________________                                         4-CF.sub.3                                                                             4-Cl      H       iPr  O    Et    OEt                                  4-Cl    4-Cl      H       iPr  O    Et    OEt                                  4-OCF.sub.3                                                                            4-Cl      H       iPr  O    Et    OEt                                  4-CF.sub.3                                                                             4-F       H       iPr  O    Et    O-iPr                                4-OCF   4-F       H       iPr  O    Et    O-iPr                                4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                            H       iPr  O    Et    O-iPr                                4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                            H       iPr  O    Et    OPh                                  4-CF.sub.3                                                                             4-Br      H       iPr  O    Et    OPh                                  4-CF.sub.3                                                                             4-Cl      4-Cl    iPr  O    Ph    OEt                                  4-Cl    4-Cl      4-Cl    iPr  O    Ph    OEt                                  4-Br    4-Cl      4-Cl    iPr  O    Ph    OEt                                  4-OCF.sub.3                                                                            4-Cl      4-Cl    iPr  O    Ph    OEt                                  4-CF.sub.3                                                                             4-F       4-Cl    tBu  O    Et    OEt                                  4-OCF.sub.3                                                                            4-F       4-Cl    tBu  O    Et    OEt                                  4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                            4-Cl    tBu  O    Et    O-iPr                                4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                            4-Cl    tBu  O    Et    O-iPr                                4-CF.sub.3                                                                             4-Cl      4-CN    Ph   O    Et    OEt                                  4-OCF.sub.3                                                                            4-Cl      4-CN    Ph   O    Et    OEt                                  4-CF.sub.3                                                                             4-F       4-CN    iPr  S    Ph    O-iPr                                4-OCF.sub.3                                                                            4-F       4-CN    tBu  S    Et    OEt                                  ______________________________________                                    

                  TABLE 29                                                         ______________________________________                                          ##STR41##                                                                     R.sub.1   R.sub.2    R.sub.3   R.sub.9                                         ______________________________________                                         4-CF.sub.3                                                                               4-Cl       H         CF.sub.3                                        4-CF.sub.3                                                                               4-F        H         CF.sub.3                                        4-OCF.sub.3                                                                              4-F        H         O-sec-Bu                                        4-CF.sub.3                                                                               4-OCF.sub.2 H                                                                             H         O-sec-Bu                                        4-Br      4-OCF.sub.2 H                                                                             H         O-sec-Bu                                        4-OCF.sub.3                                                                              4-OCF.sub.2 H                                                                             H         O-sec-Bu                                        4-CF.sub.3                                                                               4-Br       H         O-n-Bu                                          4-CF.sub.3                                                                               4-Cl       4-Cl      O-n-Bu                                          4-Cl      4-Cl       4-Cl      O-n-Bu                                          4-Br      4-Cl       4-Cl      O-n-Bu                                          4-OCF.sub.3                                                                              4-Cl       4-Cl      O-n-Bu                                          4-CF.sub.3                                                                               4-F        4-Cl      O-n-hexyl                                       4-CF.sub.3                                                                               4-OCF.sub.2 H                                                                             4-Cl      O-n-hexyl                                       4-OCF.sub.3                                                                              4-OCF.sub.2 H                                                                             4-Cl      O-n-hexyl                                       4-CF.sub.3                                                                               4-Cl       4-CN      OCH.sub.2 CCl.sub.3                             4-OCF.sub.3                                                                              4-Cl       4-CN      OCH.sub.2 CCl.sub.3                             4-CF.sub.3                                                                               4-F        4-CN      OCH.sub.2 CCl.sub.3                             4-CF.sub.3                                                                               4-Cl       4-CO.sub. 2 Me                                                                           OCH.sub.2 CH.sub.2 OEt                          ______________________________________                                    

                  TABLE 30                                                         ______________________________________                                          ##STR42##                                                                     R.sub.1 R.sub.2   R.sub.3    R.sub.10                                                                               R.sub.11                                  ______________________________________                                         4-CF.sub.3                                                                             4-Cl      H          Et      Et                                        4-CF.sub.3                                                                             4-F       H          Et      Et                                        4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                            H          Et      Et                                        4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                            H          CH.sub.2 CH.sub.2                                 4-CF.sub.3                                                                             4-Br      H          CH.sub.2 CH.sub.2                                 4-CF.sub.3                                                                             4-Cl      4-Cl       CH.sub.2 CH.sub.2                                 4-Cl    4-Cl      4-Cl       CH.sub.2 CH.sub.2                                 4-OCF.sub.3                                                                            4-Cl      4-Cl       CH.sub.2 CH.sub.2                                 4-CF.sub.3                                                                             4-F       4-Cl       CH.sub.2 CH.sub.2 CH.sub.2                        4-OCF.sub.3                                                                            4-F       4-Cl       CH.sub.2 CH.sub.2 CH.sub.2                        4-CF.sub.3                                                                             4-OCF.sub.2 H                                                                            4-Cl       CH.sub.2 CH.sub.2 CH.sub.2                        4-OCF.sub.3                                                                            4-OCF.sub.2 H                                                                            4-Cl       CH.sub.2 C(Me).sub.2 CH.sub.2                     4-CF.sub.3                                                                             4-Cl      4-CN       CH.sub.2 C(Me).sub.2 CH.sub.2                     4-OCF.sub.3                                                                            4-Cl      4-CN       CH.sub.2 C(Me).sub.2 CH.sub.2                     4-CF.sub.3                                                                             4-F       4-CN       Ph      Ph                                        4-CF.sub.3                                                                             4-Cl      4-CO.sub.2 Me                                                                             Ph      Ph                                        ______________________________________                                    

                  TABLE 31                                                         ______________________________________                                          ##STR43##                                                                     R.sub.1                                                                               R.sub.2  R.sub.3  R.sub.8  R.sub.12                                     ______________________________________                                         4-CF.sub.3                                                                            4-Cl     H        nBu      nBu                                          4-CF.sub.3                                                                            4-F      H        nBu      nBu                                          4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           H        nBu      nBu                                          4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           H        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2          4-CF.sub.3                                                                            4-Br     H        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2          4-CF.sub.3                                                                            4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                  4-Cl   4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                  4-OCF.sub.3                                                                           4-Cl     4-Cl     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                  4-CF.sub.3                                                                            4-F      4-Cl     CH.sub. 2 CH(Me)OCH(Me)CH                             4-OCF.sub.3                                                                           4-F      4-Cl     CH.sub.2 CH(Me)OCH(Me)CH                              4-CF.sub.3                                                                            4-OCF.sub.2 H                                                                           4-Cl     Et       cyclo-C.sub.6 H.sub.11                       4-OCF.sub.3                                                                           4-OCF.sub.2 H                                                                           4-Cl     Et       cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                            4-Cl     4-CN     Et       cyclo-C.sub.6 H.sub.11                       4-CF.sub.3                                                                            4-F      4-CN     iPr      CH.sub.2 CH.sub.2 CO.sub.2 Et                4-CF.sub.3                                                                            4-Cl     4-CO.sub.2 Me                                                                           CF.sub.3 2,4-di-ClPh                                  ______________________________________                                    

                  TABLE 32                                                         ______________________________________                                          ##STR44##                                                                     R.sub.1   R.sub.2    R.sub.3   R.sub.10                                        ______________________________________                                         4-CF.sub.3                                                                               4-Cl       H         tBu                                             4-CF.sub.3                                                                               4-F        H         tBu                                             4-CF.sub.3                                                                               4-OCF.sub.2 H                                                                             H         sec-Bu                                          4-OCF.sub.3                                                                              4-OCF.sub.2 H                                                                             H         sec-Bu                                          4-CF.sub.3                                                                               4-Br       H         sec-Bu                                          4-CF.sub.3                                                                               4-Cl       4-Cl      Ph                                              4-Cl      4-Cl       4-Cl      Ph                                              4-OCF.sub.3                                                                              4-Cl       4-Cl      Ph                                              4-CF.sub.3                                                                               4-F        4-Cl      4-ClPh                                          4-Cl      4-F        4-Cl      4-ClPh                                          4-OCF.sub.3                                                                              4-F        4-Cl      4-ClPh                                          4-CF.sub.3                                                                               4-OCF.sub.2 H                                                                             4-Cl      4-ClPh                                          4-OCF.sub.3                                                                              4-OCF.sub.2 H                                                                             4-Cl      2-Me-4-t-BuPh                                   4-CF.sub.3                                                                               4-Cl       4-CN      2-Me-4-t-BuPh                                   4-CF.sub.3                                                                               4-F        4-CN      2-NO.sub.2Ph                                    4-CF.sub.3                                                                               4-Cl       4-CO.sub.2 Me                                                                            2-NO.sub.2Ph                                    ______________________________________                                    

Formulation and Use

The compounds of this invention will generally be used in formulation with a carrier comprising a liquid or solid diluent or an organic solvent. Useful formulations of the compounds of this invention are prepared in conventional ways. They include dusts, baits, traps, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates, dry flowables and the like. Many of these can be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from about one to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 1% to 99% solid or liquid diluent(s). More specifically, they will contain theseingredients in the following approximate proportions:

    ______________________________________                                                    Percent by Weight                                                              Active                                                                         Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                     ______________________________________                                         Wettable Powders                                                                            25-90     0-74      0-10                                          Oil Suspensions,                                                                            1-50      40-95     0-35                                          Emulsions, Solutions                                                           (including Emulsifi-                                                           able Concentrates)                                                             Dusts        1-25      70-99     0-5                                           Granules, Baits                                                                             0.01-95   5-99      0-15                                          and Pellets                                                                    High Strength                                                                               90-99     0-10      0-2                                           Compositions                                                                   ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound.Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers," 2nd Ed., Dorland Books, Caldwell,N.J. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, N.Y., 1950.Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCurcheon's Detergents and Emulsifiers Annual," Allured Publ. Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents," Chemical Publ. Co., Inc., N.Y., 1964, list surfactants andrecommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth, etc. Preferably, ingredients should be approved by the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, griding as in a hammer or fluid energy mill. Suspensions are prepared by wet-milling (see, for example, U.S. Pat.No. 3,060,084). Granules and pellets can be made by spraying the active material upon preformed granular carriers or by agglomeration techniques See Browning "Agglomeration," Chemical Engineering, Dec. 4, 1967, pages 147 and following, and "Perry's Chemical Engineer's Handbook," 4th Ed., McGraw-Hill, N.Y., 1963, pages 8 to 59 and following.

Many of the compounds of the invention are most efficacious when applied inthe form of an emulsifiable concentrate mixed with a spray oil or spray oilconcentrate. Although any oil can be used as a spray oil, spray oils usually have these characteristics: they are not phytotoxic to the crop sprayed, and they have appropriate viscosity. Petroleum based oils are commonly used for spraying. In some areas, crop oils are preferred such asthe following:

    ______________________________________                                         Common Crop Oils Used as Spray Oils                                            ______________________________________                                         Corn Oil            Linseed Oil                                                Cottonseed Oil      Soybean Oil                                                Coconut Oil         Sunflower Oil                                              Rapeseed Oil        Olive Oil                                                  Peanut Oil          Palm Oil                                                   Safflower Oil       Sesame Oil                                                 Mustardseed Oil     Castor Oil                                                 ______________________________________                                    

The following oils also meet the criteria for a spray oil: mineral, fish and cod liver oil. Spray oil concentrates comprise a spray oil together with one or more additional ingredients such as emulsifiers and wetting agents. A number of useful spray oil and spray oil concentrates can be found in "A Guide to Agricultural Spray Adjuvants Used in the United States" by Thomson, Thomson Publications, Calif., 1986.

Examples of useful arthropodicidal formulations of compounds of the presentinvention are as follows.

EXAMPLE A Emulsifiable Concentrate

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        20%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         blend of oil soluble sulfonates and                                                                         10%                                               polyoxyethylene ethers                                                         isophorone                   70%                                               ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speed solution. A fine screen filter is included in packaging operation to insure the substantial absence of extraneous undissolved material in the product.

EXAMPLE B Wettable Powder

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        30%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         sodium alkylnaphthalenesulfonate                                                                            2%                                                sodium ligninsulfonate       2%                                                synthetic amorphous silica   3%                                                kaolinite                    63%                                               ______________________________________                                    

The active ingredient is mixed with the inert materials in a blender. Aftergrinding in a hammermill, the material is reblended and sifted through a 5-mesh screen.

EXAMPLE C Dust

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                           methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         Wettable powder of Example B 10%                                               pyrophyllite (powder)        90%                                               ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blended andthen packaged. The product is suitable for use as a dust.

EXAMPLE D Granule

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                          10%                                               (1-methylethyl)amino]thio]-N-[4-(trifluoro-                                    methyl)phenyl]amino]carbonyl]-4,5-di-hydro-1H-                                 pyrazol-4-yl]benzoate.                                                         attapulgite granules (low volative                                                                          90%                                               matter, 0.71/9/30 mm; U.S.S. No.                                               25-50 sieves)                                                                  ______________________________________                                    

The active ingredient is dissolved in a volatile solvent such as acetone and sprayed upon dedusted and pre-warmed attapulgite granules in a double cone blender. The acetone is then driven off by heating. The granules are then allowed to cool and are packaged.

EXAMPLE E Emulsifiable Concentrate

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        10%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         blend of oil soluble sulfonates                                                                              4%                                               and polyoxyethylene ethers                                                     isophorone                   86%                                               ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speed solution. A fine screen filter is included in packaging operation to insure the absence of any extraneous undissolved material in the product.

EXAMPLE F Wettable Powder

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        80%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         sodium alkylnaphthalenesulfonate                                                                            2%                                                sodium ligninsulfonate       2%                                                synthetic amorphous silica   3%                                                kaolinite                    3%                                                ______________________________________                                    

The active ingredient is blended with the inert materials in a blender. After grinding in a hammermill, the material is reblended an sifted through a U.S.S. 50-mesh screen and packaged.

EXAMPLE G Dust

    ______________________________________                                         wettable powder of Example F                                                                              5%                                                  pyrophyllite (powder)     95%                                                  ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blended andthen packaged. The product is suitable for use as a dust.

EXAMPLE H Granule

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        10%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         attapulgite granules (low volative matter,                                                                  90%                                               0.71/0.30 mm; U.S.S. No. 25-50 sieves)                                         ______________________________________                                    

The active ingredient is dissolved in a suitable solvent and sprayed onto dedusted attapulgite granules in a double cone blender. The granules are warmed to drive off solvent, cooled and packaged.

EXAMPLE I Granule

    ______________________________________                                         wettable powder of Example F                                                                             15%                                                  gypsum                    69%                                                  potassium sulfate         16%                                                  ______________________________________                                    

The ingredients are blended in a rotating mixer and water is sprayed on to accomplish granulation. When most of the material has reached the desired range of 0.1 to 0.42 mm (U.S.S. No. 18 to 40 sieves), the granules are removed, dried, and screened. Oversize material is crushed to produce additional material in the desired range. These granules contain 12% active ingredient.

EXAMPLE J Solution

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        15%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         4-butyrolactone              85%                                               ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitable fordirect, low volume application.

EXAMPLE K Oil Suspension

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)(1-                                                        20%                                               methylethyl)amino]thio]-N-[4-(trifluoromethyl)phenyl]-                         amino]carbonyl]-4,5-di-hydro-1H-pyrazol-4-yl]benzoate.                         sodium alkylnaphthalenesulfonate                                                                            4%                                                sodium ligninsulfonate       4%                                                low viscosity methyl cellulose                                                                              3%                                                attapulgite                  69%                                               ______________________________________                                    

The active ingredient is blended with the inert materials in a blender. After grinding in a hammermill to produce particles substantially all below 100 microns, the material is reblended and sifted through a U.S.S. 50-mesh screen and packaged.

EXAMPLE L Aqueous Suspension

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                         40%                                                (1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)                              phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazol-4-                               yl]benzoate.                                                                   polyacrylic acid thickener  0.3%                                               dodecyclophenol polyethylene glycol                                                                        0.5%                                               ether                                                                          disodium phosphate          1.0%                                               monosodium phosphate        0.5%                                               polyvinyl alcohol           1.0%                                               water                       56.7%                                              ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles substantially all under 5 microns in size.

EXAMPLE M Oil Suspension

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                         35.0%                                              (1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)                              phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazol-4-                               yl]benzoate.                                                                   blend of polyalcohol carboxylic                                                                            6.0%                                               esters and oil soluble petroleum                                               sulfonates                                                                     xylene range solvent        59.0%                                              ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles substantially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE N Emulsifiable Concentrate

    ______________________________________                                         methyl 7-chloro-2-[[N-[[[(hexyloxy)carbonyl]-methyl-                                                        5%                                                amino]-thio]-N-[4-(trifluoromethyl)-phenyl]amino]-                             carbonyl]-3,3a,4,5-tetrahydro-2H-benz[g]lindazole-3a-                          carboxylate.                                                                   blend of oil soluble sulfonates                                                                             4%                                                and polyoxyethylene ethers                                                     xylene                       91%                                               ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speed solution. A fine screen filter is included in packaging operation to insure the absence of any extraneous undissolved material in the product.

EXAMPLE O Wettable Powder

    ______________________________________                                         methyl 7-chloro-2-[[N-[[[(hexyloxy)carbonyl]-methyl-                                                        30%                                               amino]-thio]-N-[4-(trifluoromethyl)-phenyl]amino]-                             carbonyl]-3,3a,4,5-tetrahydro-2H-benz[g]lindazole-3a-                          carboxylate.                                                                   sodium alkylnaphthalenesulfonate                                                                            2%                                                sodium ligninsulfonate       2%                                                synthetic amorphous silica   3%                                                kaolinite                    63%                                               ______________________________________                                    

The active ingredient, warmed to reduce viscosity, is sprayed onto the inert materials in a blender. After grinding in a hammer-mill, the material is reblended and sifted through a 50 mesh screen.

EXAMPLE P Solution

    ______________________________________                                         methyl 7-chloro-2-[[N-[[[(hexyloxy)carbonyl]-methyl-                                                        10%                                               amino]-thio]-N-[4-(trifluoromethyl)-phenyl]amino]-                             carbonyl]-3,3a,4,5-tetrahydro-2H-benz[g]lindazole-3a-                          carboxylate.                                                                   isophorone                   90%                                               ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitable fordirect, low volume application.

EXAMPLE Q Bait Granules

    ______________________________________                                         methyl 4-[3-(4-chlorophenyl)-1-[[(ethoxycarbonyl)-                                                         3.0%                                               (1-methylethyl)amino]thio]-N-[4-(trifluoromethyl)-                             phenyl]amino]carbonyl]-4,5-dihydro-1H-pyrazol-4-                               yl]benzoate.                                                                   blend of polyethoxylated nonyl-                                                                            9.0%                                               phenols an sodium dodecylbenzene                                               benzene sulfonates                                                             ground up corn cobs         88.0%                                              ______________________________________                                    

The active ingredient and surfactant blend are dissolved in a suitable solvent such as acetone and sprayed onto the ground corn cobs. The granules are then dried and packaged. Compounds of Formula I, II and/or III can also be mixed with one or more other insecticides, fungicides, nematocides, bactericides, acaricides, or other biologically active compounds to form a multi-component pesticide giving an even broader spectrum of effective pesticide protection. Examples of other agriculturalprotectants with which compounds of the present invention can be mixed or formulated are as follows.

Insecticides:

3 -hydroxy-N-methylcrotonamide(dimethylphosphate)ester (monocrotophos)

methylcarbamic acid, ester with 2,3-dihydro-2,2-dimethyl-7-benzofuranol (carbofuran)

O-[2,4,5-trichloro-α-(chloromethyl)benzyl]-phosphoric acid, O',O'-dimethyl ester (tetrachlorvinphos)

2-mercaptosuccinic acid, diethyl ester, S-ester with thionophosphoric acid,dimethyl ester (malathion)

phosphorothioic acid, O,O-dimethyl, O-p-nitrophenyl ester (methyl parathion)

methylcarbamic acid, ester with α-naphthol (carbaryl) methyl O-(methylcarbamoyl)thiolacetohydroxamate (methomyl)

N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlordimeform)

O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidylphosphorothioate (diazinon)

octachlorocamphene (toxaphene)

O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN)

(S)-a-cyano-m-phenoxybenzyl(1R,3R)-3-(2,2-dibromovinyl) -2,2-dimethylcyclopropanecarboxylate (deltamethrin) Methyl

N',N'-dimethyl-N-[(methylcarbamoyl)oxy]-1-thiooxamimidate (oxamyl)

cyano(3-phenoxyphenyl)-methyl-4-chloro-a-(1-methylehtyl)benzeneacetate (fenvalerate)

(3-phenoxyphenyl)methyl(±)-cis,trans-3-(2,2-dichloro ethenyl)-2,2-dimethylcyclopropanecarboxylate (permethrin)

a-cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate (cypermethrin)

O-ethyl-S-(p-chlorophenyl)ethylphosphonodithioate (profenofos) phosphorothiolothionic acid,

O-ethyl-O-[4-(methylthio)-phenyl]-S-n-propyl ester (sulprofos).

Additional insecticides are listed hereafter by their common names: triflumuron, diflubenzureon, methoprene, buprofezin, thiodicarb, acephate,azinphosmethyl, chlorpyrifos, dimethoate, fonophos, isofenphos, methidathio, methami diphos, monocrotphos, phosmet, phosphamidon, phosal one, pirimicarb, phorate, profenofos, terbufos, trichlorfon, methoxychlor,bifenthrin, biphenate, cyfluthrin, fenpropathrin, fluvalinate, flucythrinate, tralomethrin, metaldehyde and rotenone.

Fungicides:

methyl 2-benzimidazolecarbamate (carbendazim)

tetramethylthiuram disulfide (thiuram)

n-dodecylguanidine acetate (dodine)

manganese ethylenebisdithiocarbamate (maneb)

1,4-dichloro-2,5-dimethoxybenzene (chloroneb)

methyl 1-(butylcarbamoly)-2-benzimidazolecarbamate (benomyl)

1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole (propiconazole)

2 -cyano-N-ethylcarbamoy-2 -methoxyiminoacetamide (cymoxanil)

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone (triadimefon)

N-(trichloromethylthio)tetrahydrophthalimide (captan)

N-(trichloromethylthio)phthalimide (folpet)

1-[[[bis(4-fluorophenyl)][methyl]silyl]methyl]-1H-1,2,4-triazole.

Nematocides:

S-methyl 1-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate

S-methyl

1-carbamoyl-N-(methylcarbamoyloxy)thioformimidate

N-isopropylphosphoramidic acid, O-ethyl

O'-[4-(methylthio)-m-tolyl]diester (fenamiphos)

Bactericides:

tribasic copper sulfate

streptomycin sulfate

Acaricides:

senecioic acid, ester with 2-sec-butyl-4,6-dinitrophenol (binapacryl)

6-methyl-1,3-cithiolo[4,5-β]quinoxalin-2-one (oxythioguinox)

ethyl 4,4'-dichlorobenzilate (chlorobenzilate)

1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol (dicofol)

bis(pentachloro-2,4-cyclopentadien-1-yl) (dienochlor)

tricyclohexyltin hydroxide (cyhexatin)

trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-thiazolidine-3-carboxamide (hexythiazox)

amitraz

propargite

fenbutatin-oxide

Biological

Bacillus thuringiensis

Avermectin B.

Utility

The compounds of the present invention exhibit activity against a wide spectrum of foliar and soil-inhabiting, livestock, household and public health arthropods. Those skilled in the art will recognize that not all compounds will be equally effective against all arthropods but the compounds of this invention display activity against economically important pest species, such as grasshoppers and cockroaches including German or American roaches; thrips; hemipterans: plant bugs (Miridae) suchas tarnished plant bugs, lace bugs (Tingidae), seed bugs (Lygaeidae) such as cinch bugs, stink bugs (Pentatomidae), leaf-footed bugs (Coreidae) suchas squash bug, and red bugs and stainers (Pyrrocoridae) such as cotton stainer; also homopterans such as whiteflies, aphids such as the green peach aphid, greenbug and cotton aphid, leafhoppers, spittlebugs and planthoppers such as aster leafhopper, potato leafhopper and rice planthoppers, psyllids such as pear psylla, scales (coccids and diaspidids) and mealybugs; coleopterans including weevils such as boll weevil and rice water weevil, grain borers, chrysomellid beetles such as Colorado potato beetle, flea beetles and other leaf beetles, coccinellid beetles such as Mexican bean beetle.

Activity is also shown against soil insects such as southern corn rootworm and wireworm; lepidopterous larvae including noctuids such as fall armyworm, beet armyworm, other Spodoptera spp., Heliothis spp. such as virescens, Heliothis zea, cabbage looper, green cloverworm, velvetbean caterpillar, cotton leafworm, black cut- worm, and other noctuid cutworms and including pyralids such as European corn borer, navel orange- worm, and stalk/stem borers and including tortricids like codling moth and grapeberry moth as well as other lepidopterous larvae such as pink bollworm and diamodback moth; and dipterans such as leafminer, soil maggots, midges, and tephritid fruit flies; house fly, Musca domestica; stable fly, Stomoxys calcitrans; black blow fly, Phormia regina; face fly, Musca autumnalis; black fly, Simulum meridionale; yellow fever mosquito, Aedes egypti; German cockroach, Blattella germanica; carpenter ants, Camponotus pennsylvanicus and eastern subterranean termite, Reticulitermes flavipes. The pest control afforded by the compounds of the present invention is notlimited, however, to these species.

The specific species, for which control is exemplified below, are: fall armyworm, Spodoptera frugiperda; tobacco budworm, Heliothis virescens; southern corn rootworm, Diabrotica undecimpunctata howardi; aster leafhopper, Macrosteles fascifrons. The pest control afforded by the compounds of the present invention is not limited, however, to these species.

Application

Arthropods are controlled in agricultural crops and animals and humans are protected by applying one or more of the compounds of this invention, in an effective amount, to the locus of infestation, to the area to be protected, directly to the pests to be controlled, or to their environment. A preferred method of application is by spraying with spray equipment that distributes the compound on the foliage, in the soil, or tothe plant part that is infested or needs to be protected. Alternatively, granular formulations of these compounds can be applied to soil or foliageor, optionally, incorporated into the soil. Either aerial or ground application can be used. Because of the diversity of behavior patterns andhabitats of the animal and human health species, many different methods of application are employed. These include direct and residual sprays, baits,ear tags, soil treatment and many others.

The pyrazoline compound(s) of this invention can be applied directly, but most often application will be of a formulation comprising one or more compounds of this invention, in an agriculturally suitable carrier or diluent. A most preferred method of application involves spraying a water dispersion or refined oil solution of the compounds. The compound(s) can also be incorporated into baits which are consumed or in devices such as traps and the like that entice the arthropod to ingest or otherwise contact the toxicant compound(s).

The rate of application of Formula I, II or III compounds required for effective control will depend on such factors as the species of arthropod to be controlled, the pest's life stage, its size, its location, the host crop, time of year of application, ambient moisture, temperature conditions, and the like. In general, application rates of 0.01 to 2 kg ofactive ingredient per hectare are sufficient to provide effective control in large scale field operations under normal circumstances, but as little as 0.001 kg/hectare may be sufficient or as much as 8 kg/hectare may be required for agricultural use, or 0.1 mg/ft² to 20 mg/ft² for home use, depending upon the factors listed above.

The following Examples demonstrate the control efficacy of compounds of Formulae I, II and III on specific arthropod pests wherein Compounds 1 through 55 are depicted in the Examples and Tables A, B and C and summarized in Table D, respectively.

                  TABLE D                                                          ______________________________________                                          ##STR45##                                                                     CMPD   R.sub.1 R.sub.2 Y                                                       ______________________________________                                          1     CF.sub.3                                                                               H       N(CH[CH.sub.3 ].sub.2)CO.sub.2 Et                        2     CF.sub.3                                                                               H       CO.sub.2 s-Bu                                            3     CF.sub.3                                                                               H       N(n-Bu).sub.2                                            4     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 n-hexyl                              5     CF.sub.3                                                                               H       N(CH.sub.3)CO.sub.2 n-Bu                                 6     CF.sub.3                                                                               H       N(CH.sub.3)CO.sub.2 Et                                   7     CF.sub.3                                                                               4-F     N(CH.sub.3)CO.sub.2 n-Bu                                 8     CF.sub.3                                                                               H       N(CH.sub.3)CO.sub.2 cyclohexyl                           9     CF.sub.3                                                                               H       N(CH.sub.3)CO.sub.2 n-octyl                             10     CF.sub.3                                                                               H       N(CH.sub.3)CO.sub.2 n-decyl                             11     CF.sub.3                                                                               4-F     N[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                       12     CF.sub.3                                                                               H       N(CH.sub.3)CO.sub.2 n-dodecyl                           13     CF.sub. 3                                                                              H       N(CH.sub.3)CO.sub.2 n-hexyl                             14     CF.sub.3                                                                               5-Cl    CO.sub.2 s-Bu                                           15     CF.sub.3                                                                               5-Cl    N[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                       16     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 Et                                  17     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 n-octyl                             18     CF.sub.3                                                                               4-F     CO.sub.2 s-Bu                                           19     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 n-Bu                                20     CF.sub.3                                                                               5-Cl    N[CH.sub.3 (CH.sub.3).sub.2 ]CO.sub.2 n-Bu              21     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 n-dodecyl                           22     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 cyclohexyl                          23     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 (CH.sub.2).sub.2 OBu                24     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 C.sub.14 H.sub.29                   25     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 C.sub.16 H.sub.33                   26     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 C.sub.18 H.sub.37                   27     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 C.sub.22 H.sub.45                   28     CF.sub.3                                                                               5-Cl    N(CH.sub.3)CO.sub.2 (CH.sub.2).sub.2 O(CH.sub.2).su                            b.2 OBu                                                 ______________________________________                                          ##STR46##                                                                     CMPD   R.sub.1 R.sub.2 R.sub.3                                                                              Y                                                 ______________________________________                                         29     CF.sub.3                                                                               4-Cl    4-F   N[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                 31     CF.sub.3                                                                               4-Cl    4-F   N[CH(CH.sub.3).sub.2 ]CO.sub.2 Bu                 32     CF.sub.3                                                                               4-Cl    4-F   N[CH(CH.sub.3)CH.sub.2 CH.sub.3 ]CO.sub.2                                      Et                                                33     CF.sub.3                                                                               4-Cl    4-F   CO.sub.2 s-Bu                                     34     CF.sub.3                                                                               4-Cl    4-F   N(CH.sub.3)CO.sub.2 cyclohexyl                    ______________________________________                                          ##STR47##                                                                     CMPD   R.sub.1 R.sub.2 R.sub.3                                                                              Q                                                 ______________________________________                                         30     CF.sub.3                                                                               4-Cl    4-Cl  SN[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                35     CF.sub.3                                                                               4-Cl    4-Cl  SN(CH.sub.3)CO.sub.2 s-Bu                         36     CF.sub.3                                                                               4-Cl    4-Cl  SCO.sub.2 s-Bu                                    37     Cl      4-Cl    4-Cl  SCO.sub.2 s-Bu                                    38     CF.sub.3                                                                               4-Cl    4-Cl  CO.sub.2 CH.sub.3                                 39     CF.sub.3                                                                               4-Cl    4-F   COCH.sub.3                                        40     CF.sub.3                                                                               4-Cl    4-Cl  SN[CH(CH.sub.3).sub.2 ]CO.sub.2 Et                41     CF.sub.3                                                                               4-Cl    4-Cl  COCH.sub.3                                        42     4-Cl    4-Cl    4-F   COCH.sub.3                                        43     Br      4-Cl    4-F   COCH.sub.3                                        44     CF.sub.3                                                                               4-Cl    4-F   CO.sub.2 CH.sub.3                                 45     CF.sub.3                                                                               4-Cl    4-F   COPh                                              46     CF.sub.3                                                                               4-Cl    4-Cl  COCH.sub.2 CH.sub.3                               47     CF.sub.3                                                                               4-Cl    4-Cl  COCOCH.sub.2 CH.sub.3                             48     CF.sub.3                                                                               4-Cl    4-Cl  COn-Bu                                            49     Cl      4-Cl    4-Cl  COCH.sub.3                                        50     Cl      4-Cl    4-Cl  COCH.sub.2 CH.sub.3                               51     Cl      4-Cl    4-Cl  CO.sub.2 CH.sub.3                                 52     CF.sub.3                                                                               4-Cl    4-Cl  CO-4-ClPh                                         53     CF.sub.3                                                                               4-Cl    4-Cl  COt-Bu                                            54     CF.sub.3                                                                               4-Cl    4-Cl  CO.sub.2 Ph                                       ______________________________________                                    

EXAMPLE 55 Fall Armyworm

Test units, each consisting of an 8-ounce plastic cup containing a layer ofwheat germ diet, approx. 0.5 cm thick, were prepared. Ten third-instar larvae of fall armyworm (Spodoptera frugiperda) were placed into each cup.Solutions of each of the test compounds (acetone/distilled water 75/25 solvent) were sprayed onto the cups, a single solution per set of three cups. Spraying was accomplished by passing the cups, on a conveyor belt, directly beneath a flat fan hydraulic nozzle which discharged the spray ata rate of 0.5 pounds of active ingredient per acre (about 0.55 kg/ha) at 30p.s.i. The cups were then covered and held at 27° C. and 50% relative humidity for 72 hours, after which time mortality readings were taken.

Of the compounds tested on fall armyworm, the following resulted in greaterthan or equal to 80% mortality: 1, 2, 4, 5, 6, 7, 9, 10, 11, 12, 13, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 38, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, and 54.

EXAMPLE 57 Tobacco Budworm

The test procedure of Example 56 was repeated for efficacy against third-instar larvae of the tobacco budworm (Hellothis virescens) except that mortality was assessed at 48 hours. Of the compounds tested on tobacco budworm, the following resulted in greater than or equal to 80% mortality: 2, 4, 7, 11, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 38, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 52, 53 and 54.

EXAMPLE 58 European Corn Borer

Test units, each consisting of an 8-ounce plastic cup containing a one-inchsquare of wheat germ/soyflour diet, were prepared. Five third-instar larvaeof the European corn borer (Ostrinia nubilalis) were placed into each cup. Sets of three test units were sprayed as described in Example 56 with individual solutions of the test compounds. The cups were then covered andheld at 27° C. and 50% relative humidity for 48 hours, after which time mortality readings were taken. Of the compounds tested on European corn borer, the following resulted in greater than or equal to 80% mortality: no testing.

EXAMPLE 59 Southern Corn Rootworm

Test units, each consisting of an 8-ounce plastic containing 1 sprouted corn (Zea mays) see, were prepared. Sets of three test units were sprayed as described in Example 56 with individual solutions of the test compounds. After the spray on the cups had dried, five third-instar larvaeof the southern corn rootworm (Diabrotica undecimpunctata howardi) were placed into each cup. A moistened dental wick was inserted into each sup to prevent drying and the cups were then covered. The cups were then held at 27° C. and 50% relative humidity for 48 hours, after which time mortality readings were taken.

Of the compounds tested on southern corn rootworm, the following resulted in greater than or equal to 80% mortality: 1, 2, 3, 4, 6, 7, 9, 10, 11, 13, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 35, 36, 38, 41, 42, 44, 45, 47, 48, 49 and 51.

EXAMPLE 60 Aster Leafhopper

Test units were prepared from a series of 12-ounce cups, each containing oat (Avena sativa) seedlings in a 1-inch layer of sterilized soil. Sets ofthree test units were sprayed as described in Example 56 with individual solutions of the below-listed compounds. After the oats had dried from thespraying, between 10 and 15 adult aster leafhoppers (Mascrosteles fascifroms) were aspirated into each of the cups. The cups were held at 27° C. and 50% relative humidity for 48 hours, after which time mortality readings were taken.

Of the compounds tested on aster leafhopper, the following resulted in greater than or equal to 80% mortality: 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28, 30, 31, 35, 36, 38, 41, 42, 43, 44, 45, 47, 49, 50 and 51.

EXAMPLE 61 Boll Weevil

Five adult boll weevils (Anthonomus grandis) were placed into each of a series of 9-ounce cups. The test procedure employed was then otherwise thesame as in Example 56 with three cups per treatment. Mortality readings were taken 48 hours after treatment.

Of the compounds tested on boll weevil, the following resulted in greater than or equal to 80% mortality: 16, 21, 22, 23, 24, 25, 26, 27, 28, 30, 35, 36, 38, 41, 42, 43, 44, 46, 48, 49, 50, 51, 52 and 54. 

What is claimed is:
 1. A compound of the formula: ##STR48## wherein R₁, is selected from halogen, C₁ -C₆ haloalkyl and C₁ -C₆ haloalkoxy;R₂ is halogen; R₃ is selected from H, CN, and halogen; m, n and p are each 1; and Q is C₂ to C₆ alkoxycarbonyl, or phenoxycarbonyl.
 2. A compound according to claim 1 wherein R₁ is selected from Cl, Br, CF₃, OCF₃, and OCF₂ H.
 3. A compound according to claim 1 wherein the halogen of R₃ is F or Cl.
 4. A compound according to claim 1 wherein Q is CO₂ CH₃.
 5. An arthropodicidal composition comprising an arthropodicidally effective amount of a compound according to any one of claims 1-4 and a carrier therefor.
 6. A method for controlling arthropods comprising applying to them or to their environment an arthropodicidally effective amount of a compound according to any one of claims 1-4. 